Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Irina Chuckowree"'
Autor:
Mark C. Bagley, Mohammed Baashen, Irina Chuckowree, Jessica E. Dwyer, David Kipling, Terence Davis
Publikováno v:
Pharmaceuticals, Vol 8, Iss 2, Pp 257-276 (2015)
Microwave-assisted Suzuki-Miyaura cross-coupling reactions have been employed towards the synthesis of three different MAPKAPK2 (MK2) inhibitors to study accelerated aging in Werner syndrome (WS) cells, including the cross-coupling of a 2-chloroquino
Externí odkaz:
https://doaj.org/article/8ba2c9fd6e5a45848730ec8b6ddd4744
Autor:
Paul Workman, Paul A. Clarke, Nan Chi Wan, Melanie Valenti, Stephen Shuttleworth, Peter Sheldrake, Edward McDonald, Alexander Zhyvoloup, Nahid Saghir, Anthony Robson, Giles Pergl-Wilson, Letitia Lensun, Alan T. Henley, Angela Hayes, Francesca Di Stefano, Alexis De Haven Brandon, Sharon Gowan, Adrian Folkes, Irina Chuckowree, Gary Box, Sonia Alix, Sonal Patel, Suzanne A. Eccles, Florence I. Raynaud
The phosphatidylinositide 3-kinase pathway is frequently deregulated in human cancers and inhibitors offer considerable therapeutic potential. We previously described the promising tricyclic pyridofuropyrimidine lead and chemical tool compound PI-103
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085970df8f01140213c017be9fe8aaa7
https://doi.org/10.1158/1535-7163.c.6532217
https://doi.org/10.1158/1535-7163.c.6532217
Autor:
Paul Workman, Paul A. Clarke, Nan Chi Wan, Melanie Valenti, Stephen Shuttleworth, Peter Sheldrake, Edward McDonald, Alexander Zhyvoloup, Nahid Saghir, Anthony Robson, Giles Pergl-Wilson, Letitia Lensun, Alan T. Henley, Angela Hayes, Francesca Di Stefano, Alexis De Haven Brandon, Sharon Gowan, Adrian Folkes, Irina Chuckowree, Gary Box, Sonia Alix, Sonal Patel, Suzanne A. Eccles, Florence I. Raynaud
Supplementary Figure 1 from Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b69a6d0bf7df52af3de6589e9ad5e0
https://doi.org/10.1158/1535-7163.22486067.v1
https://doi.org/10.1158/1535-7163.22486067.v1
Autor:
Paul Workman, Paul A. Clarke, Nan Chi Wan, Melanie Valenti, Stephen Shuttleworth, Peter Sheldrake, Edward McDonald, Alexander Zhyvoloup, Nahid Saghir, Anthony Robson, Giles Pergl-Wilson, Letitia Lensun, Alan T. Henley, Angela Hayes, Francesca Di Stefano, Alexis De Haven Brandon, Sharon Gowan, Adrian Folkes, Irina Chuckowree, Gary Box, Sonia Alix, Sonal Patel, Suzanne A. Eccles, Florence I. Raynaud
Supplementary Figure 3C from Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c866c66e69073421c00311e11a606c
https://doi.org/10.1158/1535-7163.22486061.v1
https://doi.org/10.1158/1535-7163.22486061.v1
Autor:
Paul Workman, Paul A. Clarke, Nan Chi Wan, Melanie Valenti, Stephen Shuttleworth, Peter Sheldrake, Edward McDonald, Alexander Zhyvoloup, Nahid Saghir, Anthony Robson, Giles Pergl-Wilson, Letitia Lensun, Alan T. Henley, Angela Hayes, Francesca Di Stefano, Alexis De Haven Brandon, Sharon Gowan, Adrian Folkes, Irina Chuckowree, Gary Box, Sonia Alix, Sonal Patel, Suzanne A. Eccles, Florence I. Raynaud
Supplementary Table 1 from Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4af932823949bf9230e37a31da950e4b
https://doi.org/10.1158/1535-7163.22486052.v1
https://doi.org/10.1158/1535-7163.22486052.v1
Autor:
Paul Workman, Paul A. Clarke, Nan Chi Wan, Melanie Valenti, Stephen Shuttleworth, Peter Sheldrake, Edward McDonald, Alexander Zhyvoloup, Nahid Saghir, Anthony Robson, Giles Pergl-Wilson, Letitia Lensun, Alan T. Henley, Angela Hayes, Francesca Di Stefano, Alexis De Haven Brandon, Sharon Gowan, Adrian Folkes, Irina Chuckowree, Gary Box, Sonia Alix, Sonal Patel, Suzanne A. Eccles, Florence I. Raynaud
Supplementary Figure 2 from Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e805e180fd509a9ec2ce653e2f2de8e
https://doi.org/10.1158/1535-7163.22486064
https://doi.org/10.1158/1535-7163.22486064
Autor:
Richard M. Angell, John Ludes-Meyers, Simon E. Ward, Michael Paradowski, Irina Chuckowree, Alexandre Bedernjak, James Lumley, Carol Villalonga Barber, Kenneth Powell, Edward Littler, Daniel Watterson, Geraldine Taylor, Elaine Thomas, Jose Gascon-Simorte, Mark E. Peeples, Michelle Thom, Jason S. McLellan, Dereck Tait, Neil Mathews, Paul R. Young, Ian M. Fraser, Morgan S.A. Gilman, James A. D. Good, G. Stuart Cockerill, Rachel Harland, Sara M. Johnson, Graham Lunn, Claire Scott, Gareth Williams
RV521 is an orally bioavailable inhibitor of respiratory syncytial virus (RSV) fusion that was identified after a lead optimization process based upon hits that originated from a physical property directed hit profiling exercise at Reviral. This exer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8371da7b3d3bd17095117d7ce4913054
https://orca.cardiff.ac.uk/id/eprint/143067/1/jm-2020-01882r.R2_Proof_hi.pdf
https://orca.cardiff.ac.uk/id/eprint/143067/1/jm-2020-01882r.R2_Proof_hi.pdf
Autor:
Graham J. Tizzard, John Spencer, Minghua Wang, Irina Chuckowree, Jahangir Amin, Simon J. Coles
Publikováno v:
Organometallics. 32:5818-5825
A series of oxindole-containing ferrocenes has been synthesized, studied in the solid state by X-ray crystallography, and tested for in vitro kinase inhibition. Many compounds show low or submicromolar activities against DYRK isoforms and VEGFR2, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::608d6dc76585fc3c4904084f168f758f
https://doi.org/10.1021/om400359m
https://doi.org/10.1021/om400359m
Autor:
Graham J. Tizzard, Neil John Press, John Spencer, Irina Chuckowree, Christine B. Baltus, Simon J. Coles, Iain J. Day
Publikováno v:
Tetrahedron Letters. 54:1211-1217
A series of alkenyl phenylboronic acid pinacol esters has been synthesized via an olefin cross-metathesis reaction of vinylphenylboronic acid pinacol ester derivatives. After catalytic hydrogenation, the resulting boronates were coupled via a microwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::458bf73dc534c5e2ca56d9663859231f
https://doi.org/10.1016/j.tetlet.2012.12.081
https://doi.org/10.1016/j.tetlet.2012.12.081
Autor:
Simon J. Coles, John A. Hartley, Jahangir Amin, Irina Chuckowree, Graham J. Tizzard, Minghua Wang, John Spencer, John Bingham
Publikováno v:
Organometallics. 32:509-513
A series of ferrocene analogues based on a 6,7-dimethoxy-N-phenylquinazolin-4-amine template has been synthesized, and two compounds were characterized in the solid state by X-ray crystallography. The compounds have been tested for in vitro anticance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::548b708bed4a92c4b14f4e571d21c6e1
https://doi.org/10.1021/om300974d
https://doi.org/10.1021/om300974d