Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Irina Butkyavichene"'
Autor:
Kathleen L Vincent, John A Moss, Mark A Marzinke, Craig W Hendrix, Peter A Anton, Richard B Pyles, Kate M Guthrie, Lauren Dawson, Trevelyn J Olive, Irina Butkyavichene, Scott A Churchman, John M Cortez, Rob Fanter, Manjula Gunawardana, Christine S Miller, Flora Yang, Rochelle K Rosen, Sara E Vargas, Marc M Baum
Publikováno v:
PLoS Medicine, Vol 15, Iss 9, p e1002655 (2018)
BACKGROUND:Intravaginal rings (IVRs) for HIV pre-exposure prophylaxis (PrEP) theoretically overcome some adherence concerns associated with frequent dosing that can occur with oral or vaginal film/gel regimens. An innovative pod-IVR, composed of an e
Externí odkaz:
https://doaj.org/article/15d47b436ff8464fa9000a5495084e34
Autor:
James M Smith, John A Moss, Priya Srinivasan, Irina Butkyavichene, Manjula Gunawardana, Rob Fanter, Christine S Miller, Debbie Sanchez, Flora Yang, Shanon Ellis, Jining Zhang, Mark A Marzinke, Craig W Hendrix, Amita Kapoor, Marc M Baum
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185946 (2017)
Globally, women bear an uneven burden for sexual HIV acquisition. Results from two clinical trials evaluating intravaginal rings (IVRs) delivering the antiretroviral agent dapivirine have shown that protection from HIV infection can be achieved with
Externí odkaz:
https://doaj.org/article/56d43e801ddb449b8ae1b9c5cfc84c23
Autor:
Priya Srinivasan, John A Moss, Manjula Gunawardana, Scott A Churchman, Flora Yang, Chuong T Dinh, James M Mitchell, Jining Zhang, Rob Fanter, Christine S Miller, Irina Butkyavichene, Janet M McNicholl, Thomas J Smith, Marc M Baum, James M Smith
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157061 (2016)
Topical preexposure prophylaxis (PrEP) against HIV has been marginally successful in recent clinical trials with low adherence rates being a primary factor for failure. Controlled, sustained release of antiretroviral (ARV) drugs may help overcome the
Externí odkaz:
https://doaj.org/article/e7cb8cfd8b6c475585836408ce0df4be
Autor:
Scott A. Churchman, Craig W. Hendrix, Rob Fanter, Irina Butkyavichene, John A. Moss, Thomas J. Smith, Christine S. Miller, Marc M. Baum, Mark A. Marzinke, Jeremiah T. Easley, Flora Yang, Manjula Gunawardana
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:3759-3766
Preexposure prophylaxis (PrEP) against HIV using oral regimens based on the nucleoside reverse transcriptase inhibitor tenofovir disoproxil fumarate (TDF) has been effective to various degrees in multiple clinical trials, and the CCR5 receptor antago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8764066650cb78ccc1fa5a3bf9aca72f
https://doi.org/10.1128/aac.00391-16
https://doi.org/10.1128/aac.00391-16
Autor:
Gilbert Lopez, Thomas J. Smith, Marc M. Baum, Christine S. Miller, Irina Butkyavichene, Scott A. Churchman, John A. Moss
Publikováno v:
International Journal of Pharmaceutics. 495:579-587
Recent clinical trials have demonstrated that pre-exposure prophylaxis (PrEP) may prevent HIV infection in a significant number of HIV-1 negative individuals in venerable populations; however, trial efficacy has been highly variable, with notable suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056e80e89ac9535236b8d7b1babb61c1
https://doi.org/10.1016/j.ijpharm.2015.09.028
https://doi.org/10.1016/j.ijpharm.2015.09.028
Autor:
Mark A. Marzinke, Jining Zhang, Rob Fanter, Priya Srinivasan, James M. Smith, Flora Yang, Craig W. Hendrix, Manjula Gunawardana, Irina Butkyavichene, Marc M. Baum, Shanon Ellis, John A. Moss, Christine S. Miller, Debbie Sanchez, Amita Kapoor
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 10, p e0185946 (2017)
PLoS ONE, Vol 12, Iss 10, p e0185946 (2017)
Globally, women bear an uneven burden for sexual HIV acquisition. Results from two clinical trials evaluating intravaginal rings (IVRs) delivering the antiretroviral agent dapivirine have shown that protection from HIV infection can be achieved with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::040ccf4564c08770cbd3959ba7105c21
http://europepmc.org/articles/PMC5628903
http://europepmc.org/articles/PMC5628903
Autor:
Etana Kopin, Joshua Gilman, James M. Smith, Irina Butkyavichene, Cassandra Cortez, Janet M. McNicholl, Preetha Sinha, Thomas J. Smith, John A. Moss, Patricia C. Guenthner, Priya Srinivasan, Marc M. Baum, Chou-Pong Pau, Cali Nguyen, Amanda M. Malone, James Mitchell, Amy Martin, Sean Kennedy, R. Michael Hendry, Angela Holder
Publikováno v:
Antimicrobial Agents and Chemotherapy. 56:5952-5960
Antiretroviral-based microbicides applied topically to the vagina may play an important role in protecting women from HIV infection. Incorporation of the nucleoside reverse transcriptase inhibitor tenofovir (TFV) into intravaginal rings (IVRs) for su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::808a26d62b9ce2f9d20f1faa2e39e7e3
https://doi.org/10.1128/aac.01198-12
https://doi.org/10.1128/aac.01198-12
Autor:
Cali Nguyen, Irina Butkyavichene, John A. Moss, Meredith R. Clark, David R. Friend, Thomas J. Smith, Marc M. Baum, Joshua Gilman, Etana Kopin, Amanda M. Malone, Sean Kennedy
Publikováno v:
Journal of Pharmaceutical Sciences. 101:2833-2843
Intravaginal delivery of microbicide combinations is a promising approach for the prevention of sexually transmitted infections, but requires a method of providing simultaneous, independent release of multiple agents into the vaginal compartment. A n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecbced11318edb0e6d3b0806bf8f7e80
https://doi.org/10.1002/jps.23208
https://doi.org/10.1002/jps.23208
Autor:
Amanda M. Malone, Irina Butkyavichene, John A. Moss, Cali Nguyen, Marc M. Baum, Kathleen L. Vincent, Etana Kopin, Robyn A. Willis, Sean Kennedy, Josh Gilman, Massoud Motamedi, Thomas J. Smith
Publikováno v:
AIDS. 26:707-710
To compare the distribution of tenofovir in sheep vaginal lumen, tissue, and plasma following topical delivery of the antiretroviral drug from intravaginal rings, either as tenofovir or the disoproxil fumarate prodrug.Comparative pharmacokinetic stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ae5959a50870e0cd6e228b4fcb1945
https://doi.org/10.1097/qad.0b013e3283509abb
https://doi.org/10.1097/qad.0b013e3283509abb
Autor:
Rob Fanter, Trevelyn J. Olive, Manjula Gunawardana, Kate M. Guthrie, Lauren N. Dawson, Craig W. Hendrix, Kathleen L. Vincent, Rochelle K. Rosen, Christine S. Miller, Peter A. Anton, John M. Cortez, Marc M. Baum, Irina Butkyavichene, John A. Moss, Scott A. Churchman, Mark A. Marzinke, Flora Yang, Richard B. Pyles, Sara E. Vargas
Publikováno v:
PLoS Medicine
PLoS Medicine, Vol 15, Iss 9, p e1002655 (2018)
PLoS Medicine, Vol 15, Iss 9, p e1002655 (2018)
Background Intravaginal rings (IVRs) for HIV pre-exposure prophylaxis (PrEP) theoretically overcome some adherence concerns associated with frequent dosing that can occur with oral or vaginal film/gel regimens. An innovative pod-IVR, composed of an e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::456c743489afebe0ee52a1c3193ce43c
https://doi.org/10.1371/journal.pmed.1002655
https://doi.org/10.1371/journal.pmed.1002655