Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Irina Apostolou"'
Autor:
Padmanee Sharma, Swetha Anandhan, James P. Allison, Ana Aparicio, Hao Zhao, Liangwen Xiong, Irina Apostolou, Xuejun Zhang, Jan Zhang, Sumit K. Subudhi, Patrick Trojer, Jill Skepner, Sangeeta Goswami
Enhancer of zeste homolog 2-mediated (EZH2-mediated) epigenetic regulation of T cell differentiation and Treg function has been described previously; however, the role of EZH2 in T cell-mediated antitumor immunity, especially in the context of immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9428f6100c5935d1fc05426cf30dc557
https://europepmc.org/articles/PMC6118570/
https://europepmc.org/articles/PMC6118570/
Autor:
Jochen Hühn, Panos Verginis, Harald von Boehmer, Irina Apostolou, Julia K. Polansky, Karsten Kretschmer
Publikováno v:
Journal of Clinical Immunology. 28:619-624
Foxp3-expressing regulatory T cells (Treg) have an essential function of preventing autoimmune disease in man and mouse. Foxp3 binds to forkhead motifs of about 1,100 genes and the strength of binding increases upon phorbol 12-myristate 13-acetate/io
Autor:
Iannis Aifantis, Ulrich H. von Andrian, M. Lucila Scimone, Harald von Boehmer, Irina Apostolou
Publikováno v:
Proceedings of the National Academy of Sciences. 103:7006-7011
Homing of bone marrow (BM)-derived progenitors to the thymus is essential for T cell development. We have previously reported that two subpopulations of common lymphoid progenitors, CLP-1 and CLP-2, coexist in the BM and give rise to lymphocytes. We
Autor:
Harald von Boehmer, Irina Apostolou
Publikováno v:
Journal of Autoimmunity. 22:111-114
Autor:
Orly Azogui, Elmar Jaeckel, Harald von Boehmer, Irina Apostolou, Fabio Grassi, Fotini Gounari, Iannis Aifantis, Ludger Klein, Loralee Haughn
Publikováno v:
Immunological Reviews. 191:62-78
Intrathymic T cell development represents one of the best studied paradigms of mammalian development. Lymphoid committed precursors enter the thymus and the Notch1 receptor plays an essential role in committing them to the T cell lineages. The pre-T
Publikováno v:
The Journal of Experimental Medicine
In type 1 diabetes, autoimmune T cells cause destruction of pancreatic β cells by largely unknown mechanism. Previous analyses have shown that β cell destruction is delayed but can occur in perforin-deficient nonobese diabetic (NOD) mice and that F
Publikováno v:
The Journal of Immunology. 165:2481-2490
NKT cells are a subset of T lymphocytes that is mainly restricted by the nonclassical MHC class I molecule, CD1d, and that includes several subpopulations, in particular CD4+ and CD4−CD8− (DN) cells. In the mouse, differential distribution of the
Autor:
Claude Grégoire, Christaiane Delarbre, Benedikt M. Kessler, Jean Charles Cerottini, Immanuel F. Luescher, Irina Apostolou, Olivier Michielin, Gabriel Gachelin, Christopher L. Blanchard, Bernard Malissen, Martin Karplus, Florian M. Wurm
Publikováno v:
Journal of Biological Chemistry. 274:3622-3631
To elucidate the structural basis of T cell recognition of hapten-modified antigenic peptides, we studied the interaction of the T1 T cell antigen receptor (TCR) with its ligand, the H-2Kd-bound Plasmodium berghei circumsporozoite peptide 252-260 (SY
Autor:
Thomas C. Spelsberg, Harald von Boehmer, Zhuoxiao Cao, Göran K. Hansson, Irina Apostolou, Malayannan Subramaniam, Xinghui Sun, Basak Icli, Christopher J. Stapleton, Fehim Esen, Mark W. Feinberg, René R. Sevag Packard, Peter Libby, Karsten Kretschmer, Akm Khyrul Wara
Publikováno v:
The Journal of biological chemistry. 284(37)
CD4(+)CD25(+) regulatory T cells (T regs) play a major role in the maintenance of self-tolerance and immune suppression, although the mechanisms controlling T reg development and suppressor function remain incompletely understood. Herein, we provide
Autor:
Katherine McLaughlin, Kai W. Wucherpfennig, Panayotis Verginis, Irina Apostolou, Harald von Boehmer
Antigen-specific transplantation tolerance in the absence of immunosuppressive drugs is a rarely achieved goal. Immune responses to Y chromosome-encoded transplantation antigens (HY) can have life-threatening consequences in the clinic. Here, we have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc9150cedce42839664356a0e612df0
https://europepmc.org/articles/PMC2265184/
https://europepmc.org/articles/PMC2265184/