Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Irina A. Kostanyan"'
Autor:
Tatiana V. Rakitina, Valery M. Lipkin, Ludmilla A. Morozova-Roche, Igor I. Babichenko, E. A. Surina, A. P. Bogachuk, N. I. Minkevich, V. V. Radchenko, Kiran Yanamandra, Irina A. Kostanyan, Elena N. Iomdina
Publikováno v:
Russian Journal of Bioorganic Chemistry. 38:605-612
We have shown previously the presence of full length (50 kD) and truncated proteolytic form (45 kD) of pigment epithelium derived factor (PEDF) in the eye Tenon's capsule in progressive myopia. The full length PEDF is prevalent in myopia that correla
Publikováno v:
Russian Journal of Bioorganic Chemistry. 36:11-23
The cell homeostasis is regulated by numerous signaling proteins. Their common task is to process extracellular signals by triggering cascades of intracellular reactions leading to modulation of down-stream gene activities. One of the important signa
Autor:
Irina A. Kostanyan, Olesya S. Moskaleva, Boris A. Margulis, Vladimir Zamotin, Ludmilla A. Morozova-Roche, Kiran Yanamandra, Anna L. Gharibyan
Publikováno v:
Journal of Molecular Biology. 365:1337-1349
Among the newly discovered amyloid properties, its cytotoxicity plays a key role. Lysozyme is a ubiquitous protein involved in systemic amyloidoses in vivo and forming amyloid under destabilising conditions in vitro. We characterized both oligomers a
Publikováno v:
Biochemistry (Moscow). 72:49-60
The effect of hexapeptide HLDF-6, the granulocytic differentiation inducer, on the tumor necrosis factor alpha (TNF-alpha)-induced differentiation and apoptosis of human promyelocytic leukemia HL-60 cells has been investigated. Costimulation of HL-60
Publikováno v:
Doklady Biochemistry and Biophysics. 410:313-316
Autor:
Irina A. Kostanyan, Kirpichnikov Mp, Anna L. Gharibyan, Ludmilla A. Morozova-Roche, Marika A. Lavrikova, Natalia V. Gibanova, Vladimir Zamotin, Dmitry A. Dolgikh
Publikováno v:
FEBS Letters. 580:2451-2457
Prefibrillar cytotoxicity was suggested as a common amyloid characteristic. We showed two types of albebetin prefibrillar oligomers are formed during incubation at pH 7.3. Initial round-shaped oligomers consist of 10–15 molecules determined by atom
Autor:
A. T. Proshin, Z. I. Storozheva, Vladimir V. Sherstnev, Valery M. Lipkin, S. S. Zhokhov, I. L. Rodionov, Irina A. Kostanyan
Publikováno v:
Bulletin of Experimental Biology and Medicine. 141:319-322
Effects of homologous peptides HLDF-6 and PEDF-6 on behavior of animals with experimental Alzheimer's disease induced by chronic intracerebroventricular administration of beta-amyloid peptide Abeta(25-35) were studied in the zoosocial recognition tes
Autor:
Arkady N. Murashev, Goncharenko En, S. S. Zhokhov, D.I. Rzhevsky, Valery M. Lipkin, Irina A. Kostanyan, A.V. Goleva, Igor I. Babichenko, A.A. Baizhumanov
Publikováno v:
Regulatory Peptides. 127:111-121
The hexapeptide Thr-Gly-Glu-Asn-His-Arg (HLDF-6), which was first identified as an active fragment of the human leukemia differentiation factor (HLDF) molecule, displays differentiation-inducing, neuroprotective and anti-drug abuse activities. Most o
Autor:
Igor I. Babichenko, E. A. Surina, Irina A. Kostanyan, N. V. Gibanova, Valery M. Lipkin, I. L. Rodionov, A. T. Proshin, Z. I. Storozheva, S. S. Zhokhov
Publikováno v:
Scopus-Elsevier
Previously we identified a six-membered fragment 354TQVEHR359 of the C-terminal part of the PEDF (Pigment Epithelium-Derived Factor) differentiation factor molecule that shares homology with fragment 41TGENHR46 of the HLDF (Human Leukemia Differentia
Autor:
Dmiltry A Dolgikh, Rita V. Chertkova, Irina A. Kostanyan, Ludmilla Morozova-Roche, Mantas Malisauskas, Marika A. Lavrikova, Kirpichnikov Mp, Anders Öhman, Vladimir Zamotin
Publikováno v:
Biochemistry. 43:9610-9619
We showed that the genetically engineered carrier-protein albebetin and its biologically active constructs with interferon-alpha(2) octapeptide LKEKKYSP or differentiation factor hexapeptide TGENHR are inherently highly amyloidogenic at physiological