Single-Domain Antibodies Efficiently Neutralize SARS-CoV-2 Variants of Concern

Autor: Irina A. Favorskaya, Dmitry V. Shcheblyakov, Ilias B. Esmagambetov, Inna V. Dolzhikova, Irina A. Alekseeva, Anastasia I. Korobkova, Daria V. Voronina, Ekaterina I. Ryabova, Artem A. Derkaev, Anna V. Kovyrshina, Anna A. Iliukhina, Andrey G. Botikov, Olga L. Voronina, Daria A. Egorova, Olga V. Zubkova, Natalia N. Ryzhova, Ekaterina I. Aksenova, Marina S. Kunda, Denis Y. Logunov, Boris S. Naroditsky, Alexandr L. Gintsburg

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Virus-neutralizing antibodies are one of the few treatment options for COVID-19. The evolution of SARS-CoV-2 virus has led to the emergence of virus variants with reduced sensitivity to some antibody-based therapies. The development of potent antibod

Externí odkaz: https://doaj.org/article/f07abc82d4394ceda24adf1504e604ad

Cross-Reactive Fc-Fused Single-Domain Antibodies to Hemagglutinin Stem Region Protect Mice from Group 1 Influenza a Virus Infection

Autor: Daria V. Voronina, Dmitry V. Shcheblyakov, Irina A. Favorskaya, Ilias B. Esmagambetov, Alina S. Dzharullaeva, Amir I. Tukhvatulin, Olga V. Zubkova, Olga Popova, Vladislav Y. Kan, Alina S. Bandelyuk, Maxim M. Shmarov, Denis Y. Logunov, Boris S. Naroditskiy, Aleksandr L. Gintsburg

Publikováno v: Viruses, Vol 14, Iss 11, p 2485 (2022)

The continued evolution of influenza viruses reduces the effectiveness of vaccination and antiviral drugs. The identification of novel and universal agents for influenza prophylaxis and treatment is an urgent need. We have previously described two po

Externí odkaz: https://doaj.org/article/55d7dfa81f674cacac3748dcc5023fce

Single-domain antibodies efficiently neutralize SARS-CoV-2 variants of concern, including Omicron variant

Autor: Ekaterina I Ryabova, Dmitry V. Shcheblyakov, Denis Y. Logunov, Andrey G Botikov, Alexandr L. Gintsburg, Irina A Alekseeva, Ekaterina I. Aksenova, Irina A Favorskaya, Olga L. Voronina, Artem A Derkaev, Natalia N. Ryzhova, Boris S. Naroditsky, M.S. Kunda, Anna V. Kovyrshina, Ilias B Esmagambetov, Daria V Voronina, Daria A. Egorova, Inna V. Dolzhikova, Anna A. Iliukhina, Anastasia I Korobkova, Olga V. Zubkova

Virus-neutralizing antibodies are one of the few treatment options for COVID-19. The evolution of SARS-CoV-2 virus has led to the emergence of virus variants with reduced sensitivity to some antibody-based therapies. The development of potent antibod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::953137976c48f1113918d4e21bcf2bb8
https://doi.org/10.1101/2021.11.24.469842

An Open, Non-Randomised, 1/2 Phase Study on the Safety, Tolerability, and Immunogenicity of Single Dose 'Sputnik Light' Vaccine for Prevention of Coronavirus Infection in Healthy Adults

Autor: Amir I. Tukhvatulin, Inna V. Dolzhikova, Dmitry V. Shcheblyakov, Olga V. Zubkova, Alina S. Dzharullaeva, Anna V. Kovyrshina, Nadezhda L. Lubenets, Daria M. Grousova, Alina S. Erokhova, Andrei G. Botikov, Fatima M. Izhaeva, Olga Popova, Tatiana A. Ozharovskaia, Ilias B. Esmagambetov, Irina A. Favorskaya, Denis I. Zrelkin, Daria V. Voronina, Dmitry N. Shcherbinin, Alexander S. Semikhin, Yana V. Simakova, Elizaveta A. Tokarskaya, Maksim M. Shmarov, Natalia A. Nikitenko, Vladimir A. Gushchin, Elena A. Smolyarchuk, Tatiana G. Zubkova, Konstantin A. Zakharov, Vasiliy B. Vasilyuk, Sergei V. Borisevich, Boris S. Naroditsky, Denis Y. Logunov, Alexander L. Gintsburg

Publikováno v: SSRN Electronic Journal.

Background: While the world is experiencing another wave of COVID-19 pandemic, global vaccination program is hampered by obvious shortage in supply of licensed vaccines. Development of new vaccines that are easy to manufacture and administer is highl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46dd4f7e36c0425bc50de16bb4665594
https://doi.org/10.2139/ssrn.3886430

Cross-Reactive Fc-Fused Single-Domain Antibodies to Hemagglutinin Stem Region Protect Mice from Group 1 Influenza a Virus Infection.

Autor: Voronina, Daria V.¹ (AUTHOR) daryavoronin2009@yandex.ru, Shcheblyakov, Dmitry V.¹ (AUTHOR), Favorskaya, Irina A.² (AUTHOR), Esmagambetov, Ilias B.¹ (AUTHOR), Dzharullaeva, Alina S.² (AUTHOR), Tukhvatulin, Amir I.² (AUTHOR), Zubkova, Olga V.¹ (AUTHOR), Popova, Olga¹ (AUTHOR), Kan, Vladislav Y.¹ (AUTHOR), Bandelyuk, Alina S.¹ (AUTHOR), Shmarov, Maxim M.¹ (AUTHOR), Logunov, Denis Y.² (AUTHOR), Naroditskiy, Boris S.¹ (AUTHOR), Gintsburg, Aleksandr L.¹ (AUTHOR)

Publikováno v: Viruses (1999-4915). Nov2022, Vol. 14 Issue 11, p2485. 19p.