Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Irina A Pikuleva"'
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0187168 (2017)
Cytochrome P450 46A1 (CYP46A1) converts cholesterol to 24-hydroxycholesterol and thereby controls the major pathways of cholesterol removal from the brain. Cyp46a1-/- mice have a reduction in the rate of cholesterol biosynthesis in the brain and sign
Externí odkaz:
https://doaj.org/article/e69897c83c49404887b646764c4d483c
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126592 (2015)
Histone deacetylase (HDAC) inhibition has promise as a therapy for Alzheimer's disease (AD) and other neurodegenerative diseases. Currently, therapeutic HDAC inhibitors target many HDAC isoforms, a particularly detrimental approach when HDAC isoforms
Externí odkaz:
https://doaj.org/article/20c628dcb6314d8499b8e261e45df447
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 6, Pp 100555- (2024)
Cytochrome P450 46A1 (CYP46A1) is the CNS-specific cholesterol 24-hydroxylase that controls cholesterol elimination and turnover in the brain. In mouse models, pharmacologic CYP46A1 activation with low-dose efavirenz or by gene therapy mitigates the
Externí odkaz:
https://doaj.org/article/c33367ff731c493e950729642ca5ebf6
Autor:
Wenchao Zheng, Rachel E Reem, Saida Omarova, Suber Huang, Pier Luigi DiPatre, Casey D Charvet, Christine A Curcio, Irina A Pikuleva
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37926 (2012)
The retina is a light-sensitive tissue lining the inner surface of the eye and one of the few human organs whose cholesterol maintenance is still poorly understood. Challenges in studies of the retina include its complex multicellular and multilayere
Externí odkaz:
https://doaj.org/article/872fa06f2eb64cddbfd836f2aa3935ff
Autor:
Alan J. Lerner, Steven E. Arnold, Erin Maxfield, Aaron Koenig, Maria E. Toth, Brooke Fortin, Natalia Mast, Bianca A. Trombetta, John Denker, Andrew A. Pieper, Curtis Tatsuoka, Sangeetha Raghupathy, Irina A. Pikuleva
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-10 (2022)
Abstract Background Efavirenz is an anti-HIV drug, and cytochrome P450 46A1 (CYP46A1) is a CNS-specific enzyme that metabolizes cholesterol to 24-hydroxycholesterol (24HC). We have previously shown that allosteric CYP46A1 activation by low-dose efavi
Externí odkaz:
https://doaj.org/article/be51f0c921904c6eb9b8ba7aa6a50ed7
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 7, Pp 100401- (2023)
The retina and brain are separated from the systemic circulation by the anatomical barriers, which are permeable (the outer blood-retinal barrier) and impermeable (the blood-brain and inner blood-retina barriers) to cholesterol. Herein we investigate
Externí odkaz:
https://doaj.org/article/5dec79429d9b43af9231e30c0cf209b6
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2242 (2024)
High dose (S)-efavirenz (EFV) inhibits the HIV reverse transcriptase enzyme and is used to lower HIV load. Low-dose EFV allosterically activates CYP46A1, the key enzyme for cholesterol elimination from the brain, and is investigated as a potential tr
Externí odkaz:
https://doaj.org/article/0e025f04b49b4cb1915f39df4ec6ebca
Autor:
Nicole El-Darzi, Natalia Mast, Sandra S. Hammer, Tim F. Dorweiler, Julia V. Busik, Irina A. Pikuleva
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 2, Pp 100323- (2023)
CYP46A1 is a CNS-specific enzyme, which eliminates cholesterol from the brain and retina by metabolism to 24-hydroxycholesterol, thus contributing to cholesterol homeostasis in both organs. 2-Hydroxypropyl-β-cyclodextrin (HPCD), a Food and Drug Admi
Externí odkaz:
https://doaj.org/article/416b987dee114e0eaef22c32059e6f1f
Autor:
Nicole El-Darzi, Natalia Mast, David A. Buchner, Aicha Saadane, Brian Dailey, Georgios Trichonas, Irina A. Pikuleva
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
A small dose of the anti-HIV drug efavirenz (EFV) was previously discovered to activate CYP46A1, a cholesterol-eliminating enzyme in the brain, and mitigate some of the manifestation of Alzheimer’s disease in 5XFAD mice. Herein, we investigated the
Externí odkaz:
https://doaj.org/article/ed746dc3793c44e1a259e662f90f526e
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Externí odkaz:
https://doaj.org/article/eb9e020a4e4e469a981b8dbd84c50e4d