Zobrazeno 1 - 10
of 268
pro vyhledávání: '"Irina, Vetter"'
Autor:
Christina N. Zdenek, Fernanda C. Cardoso, Samuel D. Robinson, Raine S. Mercedes, Enriko R. Raidjõe, María José Hernandez-Vargas, Jiayi Jin, Gerardo Corzo, Irina Vetter, Glenn F. King, Bryan G. Fry, Andrew A. Walker
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110723- (2024)
Summary: Kissing bugs are known to produce anticoagulant venom that facilitates blood-feeding. However, it is unknown how this saliva evolved and if the venom produced by the entomophagous ancestors of kissing bugs would have helped or hindered the t
Externí odkaz:
https://doaj.org/article/c7ebb8f5f71349499699a1a3ac14234a
Autor:
Anil Kumar Kalia, Corinna Rösseler, Rafael Granja-Vazquez, Ayesha Ahmad, Joseph J. Pancrazio, Anika Neureiter, Mei Zhang, Daniel Sauter, Irina Vetter, Asa Andersson, Gregory Dussor, Theodore J. Price, Benedict J. Kolber, Vincent Truong, Patrick Walsh, Angelika Lampert
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-28 (2024)
Abstract Background Human induced pluripotent stem cell (iPSC)-derived peripheral sensory neurons present a valuable tool to model human diseases and are a source for applications in drug discovery and regenerative medicine. Clinically, peripheral se
Externí odkaz:
https://doaj.org/article/64b0342489ca43859d062555e3986dc2
Autor:
Md. Habibur Rahaman, Sara J. Thygesen, Michael J. Maxwell, Hyoyoung Kim, Prerna Mudai, Jeffrey D. Nanson, Xinying Jia, Parimala R. Vajjhala, Andrew Hedger, Irina Vetter, Thomas Haselhorst, Avril A. B. Robertson, Brian Dymock, Thomas Ve, Mehdi Mobli, Katryn J. Stacey, Bostjan Kobe
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractToll-like receptor (TLR) innate immunity signalling protects against pathogens, but excessive or prolonged signalling contributes to a range of inflammatory conditions. Structural information on the TLR cytoplasmic TIR (Toll/interleukin-1 rec
Externí odkaz:
https://doaj.org/article/dcf8b7e19c924597be45dfa99851bf23
Autor:
Priscilla Galante, Gabriel A. A. Campos, Jacqueline C. G. Moser, Danubia B. Martins, Marcia P. dos Santos Cabrera, Marisa Rangel, Luiza C. Coelho, Karina S. Simon, Veronica M. Amado, Jessica de A. I. Muller, Johannes Koehbach, Rink-Jan Lohman, Peter J. Cabot, Irina Vetter, David J. Craik, Monica C. Toffoli-Kadri, Victoria Monge-Fuentes, Jair T. Goulart, Elisabeth F. Schwartz, Luciano P. Silva, Anamelia L. Bocca, Márcia R. Mortari
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Animal venoms are rich sources of neuroactive compounds, including anti-inflammatory, antiepileptic, and antinociceptive molecules. Our study identified a protonectin peptide from the wasp Parachartergus fraternus' venom using mass spectrome
Externí odkaz:
https://doaj.org/article/b67d9db1535243309705120d264359b7
Autor:
Samuel D. Robinson, Jennifer R. Deuis, Axel Touchard, Angelo Keramidas, Alexander Mueller, Christina I. Schroeder, Valentine Barassé, Andrew A. Walker, Nina Brinkwirth, Sina Jami, Elsa Bonnafé, Michel Treilhou, Eivind A. B. Undheim, Justin O. Schmidt, Glenn F. King, Irina Vetter
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Stings of certain ant species (Hymenoptera: Formicidae) can cause intense, long-lasting nociception. Here we show that the major contributors to these symptoms are venom peptides that modulate the activity of voltage-gated sodium (NaV) chann
Externí odkaz:
https://doaj.org/article/06020d0862264dda9a11dae6073fc211
Autor:
Sina Jami, Jennifer R. Deuis, Tabea Klasfauseweh, Xiaoyang Cheng, Sergey Kurdyukov, Felicity Chung, Andrei L. Okorokov, Shengnan Li, Jiangtao Zhang, Ben Cristofori-Armstrong, Mathilde R. Israel, Robert J. Ju, Samuel D. Robinson, Peng Zhao, Lotten Ragnarsson, Åsa Andersson, Poanna Tran, Vanessa Schendel, Kirsten L. McMahon, Hue N. T. Tran, Yanni K.-Y. Chin, Yifei Zhu, Junyu Liu, Theo Crawford, Saipriyaa Purushothamvasan, Abdella M. Habib, David A. Andersson, Lachlan D. Rash, John N. Wood, Jing Zhao, Samantha J. Stehbens, Mehdi Mobli, Andreas Leffler, Daohua Jiang, James J. Cox, Stephen G. Waxman, Sulayman D. Dib-Hajj, G. Gregory Neely, Thomas Durek, Irina Vetter
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Voltage-gated sodium (NaV) channels are critical regulators of neuronal excitability and are targeted by many toxins that directly interact with the pore-forming α subunit, typically via extracellular loops of the voltage-sensing domains, o
Externí odkaz:
https://doaj.org/article/ef7fee6301d340c5b67edc494cc4b801
Autor:
Michael J. Maxwell, Chris Thekkedam, Cedric Lamboley, Yanni K.-Y. Chin, Theo Crawford, Jennifer J. Smith, Junyu Liu, Xinying Jia, Irina Vetter, Derek R. Laver, Bradley S. Launikonis, Angela Dulhunty, Eivind A. B. Undheim, Mehdi Mobli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Insect toxins with tandem repeats of neurotoxin domains have been found with enhanced receptor avidity. Here, the authors describe a bivalent toxin from remipede venom that targets ryanodine receptors, a rare target for animal venoms.
Externí odkaz:
https://doaj.org/article/ecfef30c1c5e4dc1ab651ec6f5d81576
Autor:
Samuel D. Robinson, Vanessa Schendel, Christina I. Schroeder, Sarah Moen, Alexander Mueller, Andrew A. Walker, Naomi McKinnon, G. Gregory Neely, Irina Vetter, Glenn F. King, Eivind A. B. Undheim
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-19 (2023)
Abstract Background Eusociality is widely considered to evolve through kin selection, where the reproductive success of an individual’s close relative is favored at the expense of its own. High genetic relatedness is thus considered a prerequisite
Externí odkaz:
https://doaj.org/article/d7dcdb11b76c4cd2a50d33482f7f16f4
Autor:
Naiqi Shi, Tibor G. Szanto, Jia He, Christina I. Schroeder, Andrew A. Walker, Jennifer R. Deuis, Irina Vetter, György Panyi, Glenn F. King, Samuel D. Robinson
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Most species of bee are capable of delivering a defensive sting which is often painful. A solitary lifestyle is the ancestral state of bees and most extant species are solitary, but information on bee venoms comes predominantly from studies
Externí odkaz:
https://doaj.org/article/a7b944fd6ac7465eb9bd2a5495f1a26e
Publikováno v:
Toxins, Vol 16, Iss 1, p 55 (2024)
µ-Conotoxins are small, potent pore-blocker inhibitors of voltage-gated sodium (NaV) channels, which have been identified as pharmacological probes and putative leads for analgesic development. A limiting factor in their therapeutic development has
Externí odkaz:
https://doaj.org/article/26cd559e85ab4274bb8dcdf46263cf5d