Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Irina, Pleines"'
Publikováno v:
Platelets, Vol 32, Iss 5, Pp 601-607 (2021)
Investigation of the bone marrow as the main compartment of hematopoiesis is critical in many research fields. Here, we adapted a centrifugation-based method for the isolation of murine bone marrow and compared it to the traditional flushing method.
Externí odkaz:
https://doaj.org/article/1f9e045165c54251bc72de94a8599854
Autor:
Timo Vögtle, Ayesha A. Baig, Julia Volz, Timothy B. Duchow, Irina Pleines, Sebastian Dütting, Lars Nitschke, Stephen P. Watson, Bernhard Nieswandt
Publikováno v:
Platelets, Vol 31, Iss 6, Pp 801-811 (2020)
Platelets are essential for normal hemostasis; however, pathological conditions can also trigger unwanted platelet activation precipitating thrombosis and ischemic damage of vital organs such as the heart or brain. Glycoprotein (GP)VI- and C-type lec
Externí odkaz:
https://doaj.org/article/b84ba99bcc4f4a65985d1c482889fe84
Publikováno v:
Platelets, Vol 30, Iss 6, Pp 698-707 (2019)
Inherited or acquired disorders of platelet production and function can result in thrombocytopenia and bleeding. Mouse models have proven useful for investigating the mechanisms that underlie these defects in humans. Precise methods for blood withdra
Externí odkaz:
https://doaj.org/article/9f51ccd9f45d4e7db8cd30ec76c979b9
Publikováno v:
Platelets, Vol 30, Iss 1, Pp 9-16 (2019)
Megakaryocytes differentiate from hematopoietic stem cells in the bone marrow. The transition of megakaryocytes to platelets is a complex process. Thereby, megakaryocytes extend proplatelets into sinusoidal blood vessels, where the proplatelets under
Externí odkaz:
https://doaj.org/article/5ccf13a380af467c8eab8655b17179f1
Autor:
Inga Scheller, Simon Stritt, Sarah Beck, Bing Peng, Irina Pleines, Katrin G. Heinze, Attila Braun, Oliver Otto, Robert Ahrends, Albert Sickmann, Markus Bender, Bernhard Nieswandt
Publikováno v:
Haematologica, Vol 105, Iss 6 (2020)
Platelet aggregate formation is a multistep process involving receptor-mediated, as well as biomechanical, signaling cascades, which are highly dependent on actin dynamics. We have previously shown that actin depolymerizing factor (ADF)/n-cofilin and
Externí odkaz:
https://doaj.org/article/3210c51d380148f59dedc478c1e5a825
Autor:
Sebastian Dütting, Frederique Gaits-Iacovoni, David Stegner, Michael Popp, Adrien Antkowiak, Judith M.M. van Eeuwijk, Paquita Nurden, Simon Stritt, Tobias Heib, Katja Aurbach, Oguzhan Angay, Deya Cherpokova, Niels Heinz, Ayesha A. Baig, Maximilian G. Gorelashvili, Frank Gerner, Katrin G. Heinze, Jerry Ware, Georg Krohne, Zaverio M. Ruggeri, Alan T. Nurden, Harald Schulze, Ute Modlich, Irina Pleines, Cord Brakebusch, Bernhard Nieswandt
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Platelets derive from large precursor cells (megakaryocytes) in the bone marrow. Düttinget al. show that megakaryocyte polarization and platelet biogenesis in the bone-marrow sinusoids are directed by adhesion receptor GPIb signalling and resulting
Externí odkaz:
https://doaj.org/article/9a41c7db2ef649429ea7c2db2ddf72fe
Autor:
Magdolna Nagy, Johanna P. van Geffen, David Stegner, David J. Adams, Attila Braun, Susanne M. de Witt, Margitta Elvers, Mitchell J. Geer, Marijke J. E. Kuijpers, Karl Kunzelmann, Jun Mori, Cécile Oury, Joachim Pircher, Irina Pleines, Alastair W. Poole, Yotis A. Senis, Remco Verdoold, Christian Weber, Bernhard Nieswandt, Johan W. M. Heemskerk, Constance C. F. M. J. Baaten
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 6 (2019)
Genetically modified mice are indispensable for establishing the roles of platelets in arterial thrombosis and hemostasis. Microfluidics assays using anticoagulated whole blood are commonly used as integrative proxy tests for platelet function in mic
Externí odkaz:
https://doaj.org/article/bf144e9b91d74d40b88d09d030089336
Autor:
Isabelle C. Becker, Zoltan Nagy, Georgi Manukjan, Melanie Haffner-Luntzer, Maximilian Englert, Tobias Heib, Timo Vögtle, Carina Gross, Richa Bharti, Sascha Dietrich, Kristina Mott, Johannes Heck, Sebastian Stegmaier, Anke Baranowsky, Thorsten Schinke, Nicolas Schlegel, Tobias Heckel, David Stegner, Irina Pleines, Anita Ignatius, Harald Schulze, Bernhard Nieswandt
Publikováno v:
Blood Advances. 6:3155-3161
G6b-B is a megakaryocyte lineage-specific immunoreceptor tyrosine-based inhibition motif–containing receptor, essential for platelet homeostasis. Mice with a genomic deletion of the entire Mpig6b locus develop severe macrothrombocytopenia and myelo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f476c5fa59f76b4935de2d5584cbac8
https://doi.org/10.1182/bloodadvances.2021006151
https://doi.org/10.1182/bloodadvances.2021006151
Autor:
Harald Schulze, J. Heck, T. Heib, R. Bharti, M. Haffner-Luntzer, Bernhard Nieswandt, A. Ignatius, Georgi Manukjan, M. Englert, S. Dietrich, K. Mott, I. C. Becker, Irina Pleines, N. Schlegel, T. Schinke, T. Heckel, A. Jeschke, Zoltan Nagy, C. Gross, T. Voegtle, David Stegner
G6b-B is a megakaryocyte lineage-specific immunoreceptor tyrosine-based inhibition motif (ITIM)-containing receptor, essential for platelet homeostasis. Mice with a genomic deletion of the entire Mpig6b locus develop severe macrothrombocytopenia and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b6ec234f36584a15a8fcecb1064d9c0
https://doi.org/10.1101/2021.11.11.468226
https://doi.org/10.1101/2021.11.11.468226
Autor:
Maximilian Englert, Katja Aurbach, Isabelle C. Becker, Annika Gerber, Tobias Heib, Lou M. Wackerbarth, Charly Kusch, Kristina Mott, Gabriel H. M. Araujo, Ayesha A. Baig, Sebastian Dütting, Ulla G. Knaus, Christian Stigloher, Harald Schulze, Bernhard Nieswandt, Irina Pleines, Zoltan Nagy
Publikováno v:
Blood advances. 6(17)
Megakaryocytes are large cells in the bone marrow that give rise to blood platelets. Platelet biogenesis involves megakaryocyte maturation, the localization of the mature cells in close proximity to bone marrow sinusoids, and the formation of protrus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5561274d89202a19d9111fe8bad368
https://pubmed.ncbi.nlm.nih.gov/35819450
https://pubmed.ncbi.nlm.nih.gov/35819450