Maternal inhalation of carbon black nanoparticles induces neurodevelopmental changes in mouse offspring

Autor: Masakazu Umezawa, Atsuto Onoda, Irina Korshunova, Alexander C. Ø. Jensen, Ismo K. Koponen, Keld A. Jensen, Konstantin Khodosevich, Ulla Vogel, Karin S. Hougaard

Publikováno v: Particle and Fibre Toxicology, Vol 15, Iss 1, Pp 1-18 (2018)

Abstract Background Engineered nanoparticles are smaller than 100 nm and designed to improve or creating even new physico-chemical properties. Consequently, toxicological properties of materials may change as size reaches the nm size-range. We examin

Externí odkaz: https://doaj.org/article/4bfd3095277642c6a8e11aa3924ef07f

Neuroprotective and memory enhancing properties of a dual agonist of the FGF receptor and NCAM

Autor: Maj N. Enevoldsen, Artur Kochoyan, Monika Jurgenson, Külli Jaako, Oksana Dmytriyeva, Peter S. Walmod, Jesper D. Nielsen, Janne Nielsen, Shizhong Li, Irina Korshunova, Boris Klementiev, Tatiana Novikova, Alexander Zharkovsky, Vladimir Berezin, Elisabeth Bock

Publikováno v: Neurobiology of Disease, Vol 48, Iss 3, Pp 533-545 (2012)

The fibroblast growth factor receptor (FGFR) plays a vital role in the development of the nervous system regulating a multitude of cellular processes. One of the interaction partners of the FGFR is the neural cell adhesion molecule (NCAM), which is k

Externí odkaz: https://doaj.org/article/9fcbe29b8a84470280cc234b1ecce148

Maternal inflammation has a profound effect on cortical interneuron development in a stage and subtype-specific manner

Autor: Maria Pardo-Navarro, Ulrich Pfisterer, Michaela Kerstin Müller, Susmita Malwade, Karin Sørig Hougaard, Konstantin Khodosevich, Jakob von Engelhardt, Janina Gasthaus, Navneet A. Vasistha, Dilys Weijers, Irina Korshunova, Diego García-González

Publikováno v: Vasistha, N A, Pardo-Navarro, M, Gasthaus, J, Weijers, D, Müller, M K, García-González, D, Malwade, S, Korshunova, I, Pfisterer, U, von Engelhardt, J, Hougaard, K S & Khodosevich, K 2020, ' Maternal inflammation has a profound effect on cortical interneuron development in a stage and subtype-specific manner ', Molecular Psychiatry, vol. 25, pp. 2313-2329 . https://doi.org/10.1038/s41380-019-0539-5
Molecular Psychiatry

Severe infections during pregnancy are one of the major risk factors for cognitive impairment in the offspring. It has been suggested that maternal inflammation leads to dysfunction of cortical GABAergic interneurons that in turn underlies cognitive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e3953df29269d7b8d108ee066b6ab8
https://curis.ku.dk/portal/da/publications/maternal-inflammation-has-a-profound-effect-on-cortical-interneuron-development-in-a-stage-and-subtypespecific-manner(bdab8550-a01d-4c6c-bea5-4bb90ccad77e).html

The soluble neurexin-1β ectodomain causes calcium influx and augments dendritic outgrowth and synaptic transmission

Autor: Ellis Pedersen, Trine Lisberg Toft-Bertelsen, Andreas B. Kønig, Jakob B. Sørensen, Casper René Gøtzsche, Irina Korshunova, Janne Nielsen, Melanie Schupp, Sylwia Owczarek, Michelle D. Gjørlund, Marie Louise Bang, Keimpe D. Wierda, Elisabeth Bock

Publikováno v: Wierda, K D B, Toft-Bertelsen, T L, Gøtzsche, C R, Pedersen, E, Korshunova, I, Nielsen, J, Bang, M L, Kønig, A B, Owczarek, S, Gjørlund, M D, Schupp, M, Bock, E & Sørensen, J B 2020, ' The soluble neurexin-1β ectodomain causes calcium influx and augments dendritic outgrowth and synaptic transmission ', Scientific Reports, vol. 10, no. 1, 18041 . https://doi.org/10.1038/s41598-020-75047-z
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)

Classically, neurexins are thought to mediate synaptic connections through trans interactions with a number of different postsynaptic partners. Neurexins are cleaved by metalloproteases in an activity-dependent manner, releasing the soluble extracell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674388558f2e2e86d02f25c248aca62e
https://curis.ku.dk/portal/da/publications/the-soluble-neurexin1-ectodomain-causes-calcium-influx-and-augments-dendritic-outgrowth-and-synaptic-transmission(da8a9cb1-c710-4c4a-9321-574eaeb859d3).html

Maternal inhalation of carbon black nanoparticles induces neurodevelopmental changes in mouse offspring

Autor: Irina Korshunova, Ismo K. Koponen, Keld Alstrup Jensen, Atsuto Onoda, Masakazu Umezawa, Alexander C. Ø. Jensen, Karin Sørig Hougaard, Konstantin Khodosevich, Ulla Vogel

Publikováno v: Umezawa, M, Onoda, A, Korshunova, I, Jensen, A C O, Koponen, I K, Jensen, K A, Khodosevich, K, Vogel, U B & Hougaard, K S 2018, ' Maternal inhalation of carbon black nanoparticles induces neurodevelopmental changes in mouse offspring ', Particle and Fibre Toxicology, vol. 15, no. 36 . https://doi.org/10.1186/s12989-018-0272-2
Particle and Fibre Toxicology
Umezawa, M, Onoda, A, Korshunova, I, Jensen, A C Ø, Koponen, I K, Jensen, K A, Khodosevich, K, Vogel, U & Hougaard, K S 2018, ' Maternal inhalation of carbon black nanoparticles induces neurodevelopmental changes in mouse offspring ', Particle and Fibre Toxicology, vol. 15, 36, pp. 1-18 . https://doi.org/10.1186/s12989-018-0272-2
Particle and Fibre Toxicology, Vol 15, Iss 1, Pp 1-18 (2018)

Background Engineered nanoparticles are smaller than 100 nm and designed to improve or creating even new physico-chemical properties. Consequently, toxicological properties of materials may change as size reaches the nm size-range. We examined outcom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ff01bc45171576042777cf77993cb65
https://orbit.dtu.dk/en/publications/98730578-f5ad-4ed2-9d19-eb60b62afbdd