Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Irina, Culminskaya"'
Autor:
Alexander M. Kulminski, Ethan Jain‐Washburn, Ian Philipp, Yury Loika, Elena Loiko, Irina Culminskaya
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 2, Pp n/a-n/a (2024)
Abstract INTRODUCTION The variability in apolipoprotein E (APOE) ε4‐attributed susceptibility to Alzheimer's disease (AD) across ancestries, sexes, and ages may stem from the modulating effects of other genetic variants. METHODS We examined associ
Externí odkaz:
https://doaj.org/article/f942fc4def444aaf801aad1a51aec5af
Autor:
Alexander M. Kulminski, Leonardo Shu, Yury Loika, Liang He, Alireza Nazarian, Konstantin Arbeev, Svetlana Ukraintseva, Anatoliy Yashin, Irina Culminskaya
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction Apolipoprotein E (APOE) ε2 and ε4 alleles encoded by rs7412 and rs429358 polymorphisms, respectively, are landmark contra and pro “risk” factors for Alzheimer's disease (AD). Methods We examined differences in linkage dise
Externí odkaz:
https://doaj.org/article/f05849ada38a4a9b97436d5ad301e47c
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction As a multifactorial polygenic disorder, Alzheimer's disease (AD) can be associated with complex haplotypes or compound genotypes. Methods We examined associations of 4960 single nucleotide polymorphism (SNP) triples, comprising
Externí odkaz:
https://doaj.org/article/204760467c9a4268896f1487ce7e27e4
Publikováno v:
GeroScience. 45:233-247
The mechanisms of incomplete penetrance of risk-modifying impacts of apolipoprotein E (APOE) ε2 and ε4 alleles on Alzheimer’s disease (AD) have not been fully understood. We performed genome-wide analysis of differences in linkage disequilibrium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06c7d5723c66a15d87eb65920ff37008
https://doi.org/10.1007/s11357-022-00617-0
https://doi.org/10.1007/s11357-022-00617-0
Autor:
Alexander M. Kulminski, Yury Loika, Jian Huang, Konstantin G. Arbeev, Olivia Bagley, Svetlana Ukraintseva, Anatoliy I. Yashin, Irina Culminskaya
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Age-related phenotypes are characterized by genetic heterogeneity attributed to an uncertain role of evolution in establishing their molecular mechanisms. Here, we performed univariate and pleiotropic meta-analyses of 24 age-related phenotypes dealin
Externí odkaz:
https://doaj.org/article/1168208983384b4b9c23c23a9ca47ba6
Publikováno v:
GeroScience
Epidemiological studies report beneficial associations of higher educational attainment (EDU) with Alzheimer’s disease (AD). Prior genome-wide association studies (GWAS) also reported variants associated with AD and EDU separately. The analysis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a25e9d937f1d3ac41d117807423aa20b
http://europepmc.org/articles/PMC8572080
http://europepmc.org/articles/PMC8572080
Autor:
Alexander M. Kulminski, Ethan Jain‐Washburn, Ian Philipp, Liang He, Yury Loika, Elena Loiko, Olivia Bagley, Svetlana Ukraintseva, Anatoliy Yashin, Konstantin Arbeev, Eric Stallard, Mary F. Feitosa, Nicole Schupf, Kaare Christensen, Irina Culminskaya
Publikováno v:
Aging Cell. 21
Age-related diseases characteristic of post-reproductive life, aging, and life span are the examples of polygenic non-Mendelian traits with intricate genetic architectures. Polygenicity of these traits implies that multiple variants can impact their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c0ff7575b94bde4803356c88af5bd2b
https://doi.org/10.1111/acel.13730
https://doi.org/10.1111/acel.13730
Publikováno v:
Alzheimers Dement
INTRODUCTION Despite advances, understanding the protective role of the apolipoprotein E (APOE) e2 allele in Alzheimer's disease (AD) remains elusive. METHODS We examined associations of variants comprised of the TOMM40 rs8106922 and APOE rs405509, r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27ece2abeb62d6284664a74f4f59d38
https://doi.org/10.1002/alz.12413
https://doi.org/10.1002/alz.12413
Autor:
Alexander M, Kulminski, Ethan, Jain-Washburn, Elena, Loiko, Yury, Loika, Fan, Feng, Irina, Culminskaya
Publikováno v:
Aging. 14
Capturing the genetic architecture of Alzheimer's disease (AD) is challenging because of the complex interplay of genetic and non-genetic factors in its etiology. It has been suggested that AD biomarkers may improve the characterization of AD patholo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ce7efcea82e007e4425aadc8c7c19ce9
https://pubmed.ncbi.nlm.nih.gov/36399096
https://pubmed.ncbi.nlm.nih.gov/36399096
The mechanisms of incomplete penetrance of risk modifying impacts of apolipoprotein E (APOE) ε2 and ε4 alleles on Alzheimer’s disease (AD) have not been fully understood. We performed genome-wide analysis of differences in linkage disequilibrium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::916b928f71d00ba810ed627085b736a7
https://doi.org/10.1101/2022.06.16.22276523
https://doi.org/10.1101/2022.06.16.22276523
