Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Irina, Arnaoutova"'
Autor:
Lan Xiao, Vinay Kumar Sharma, Leila Toulabi, Xuyu Yang, Cheol Lee, Daniel Abebe, Areg Peltekian, Irina Arnaoutova, Hong Lou, Y. Peng Loh
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Stress leads to brain pathology including hippocampal degeneration, cognitive dysfunction, and potential mood disorders. Hippocampal CA3, a most stress-vulnerable region, consists of pyramidal neurons that regulate cognitive functions e.g. l
Externí odkaz:
https://doaj.org/article/fed6035b1209439ab575098f409a57b1
Autor:
Sudeep, Gautam, Lisa, Zhang, Cheol, Lee, Irina, Arnaoutova, Hung Dar, Chen, Roberta, Resaz, Alessandra, Eva, Brian C, Mansfield, Janice Y, Chou
Publikováno v:
Hum Mol Genet
Type Ib glycogen storage disease (GSD-Ib) is caused by a deficiency in the glucose-6-phosphate (G6P) transporter (G6PT) that translocates G6P from the cytoplasm into the endoplasmic reticulum lumen, where the intraluminal G6P is hydrolyzed to glucose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15acb7c49c29bf281626e89fdd6ae86a
https://doi.org/10.1093/hmg/ddac197
https://doi.org/10.1093/hmg/ddac197
Publikováno v:
Mol Ther
Glycogen storage disease type Ia (GSD-Ia), deficient in glucose-6-phosphatase-α (G6PC), is characterized by impaired glucose homeostasis and a hallmark of fasting hypoglycemia. We have developed a recombinant adeno-associated virus (rAAV) vector-med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceab1c936623fbe134acbbfa759038d9
https://doi.org/10.1016/j.ymthe.2020.12.027
https://doi.org/10.1016/j.ymthe.2020.12.027
Autor:
Javier Anduaga, Matthew F. Starost, Cheol Woo Lee, Lisa Zhang, Brian C. Mansfield, Irina Arnaoutova, Janice Y. Chou
Publikováno v:
Biochem Biophys Res Commun
The current phase I/II clinical trial for human glycogen storage disease type-Ia (GSD-Ia) (NCT 03517085) uses a recombinant adeno-associated virus (rAAV) vector expressing a codon-optimized human glucose-6-phosphatase-α (G6Pase-α or G6PC). DNA sequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::797f1319adc8958f6b15a23218cd501d
https://doi.org/10.1016/j.bbrc.2020.04.124
https://doi.org/10.1016/j.bbrc.2020.04.124
Autor:
Janice Y. Chou, Cheol Woo Lee, Brian C. Mansfield, Irina Arnaoutova, Sudeep Gautam, Lisa Zhang
Publikováno v:
Hum Mol Genet
Glucose-6-phosphatase-α (G6Pase-α or G6PC) deficiency in glycogen storage disease type-Ia (GSD-Ia) leads to impaired hepatic autophagy, a recycling process important for cellular metabolism and homeostasis. Autophagy can be regulated by several ene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03cbbb9d9085de0f8ec6203a60678b18
https://doi.org/10.1093/hmg/ddaa007
https://doi.org/10.1093/hmg/ddaa007
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123312 (2015)
Many anti-cancer drugs fail in human trials despite showing efficacy in preclinical models. It is clear that the in vitro assays involving 2D monoculture do not reflect the complex extracellular matrix, chemical, and cellular microenvironment of the
Externí odkaz:
https://doaj.org/article/55f7a83ab69040f4972fa455d8dc9b8a
Publikováno v:
J Inherit Metab Dis
Glycogen storage disease type-Ia (GSD-Ia), caused by a deficiency in glucose-6-phosphatase-α (G6Pase-α or G6PC), is characterized by impaired glucose homeostasis with a hallmark hypoglycemia, following a short fast. We have shown that G6pc-deficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8199654a40639f2987c3ba16db1fc90
https://doi.org/10.1002/jimd.12069
https://doi.org/10.1002/jimd.12069
Autor:
Y. Peng Loh, Lan Xiao, Irina Arnaoutova, Areg Peltekian, Vinay Kumar Sharma, Hong Lou, Xuyu Yang, Daniel Abebe, Leila Toulabi, Cheol Woo Lee
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-13 (2021)
Translational Psychiatry
Translational Psychiatry
Stress leads to brain pathology including hippocampal degeneration, cognitive dysfunction, and potential mood disorders. Hippocampal CA3, a most stress-vulnerable region, consists of pyramidal neurons that regulate cognitive functions e.g. learning a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88540640beac57c531bf859673066181
https://doi.org/10.1038/s41398-020-01112-w
https://doi.org/10.1038/s41398-020-01112-w
Autor:
Yoke Peng Loh, Daniel Abebe, Lan Xiao, Xuyu Yang, Leila Toulabi, Cheol Woo Lee, Vinay Kumar Sharma, Areg Peltekian, Irina Arnaoutova
Publikováno v:
Journal of the Endocrine Society
Stress causes release of glucocorticoids from the adrenals which then circulate to the brain. High concentrations glucocorticoid from chronic severe stress results in pathophysiology in the brain, including neuronal degeneration, cell death and cogni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0248a8aac090be7cdaf8aafe51f2ef32
http://europepmc.org/articles/PMC7208088
http://europepmc.org/articles/PMC7208088
Publikováno v:
Angiogenesis. 12:267-274
It has been more than 20 years since it was first demonstrated that endothelial cells will rapidly form capillary-like structures in vitro when plated on top of a reconstituted basement membrane extracellular matrix (BME, Matrigel, EHS matrix, etc.).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00bb1d904b770cc439cf43d86d9a8b43
https://doi.org/10.1007/s10456-009-9146-4
https://doi.org/10.1007/s10456-009-9146-4