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Akademický článek

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Irilone, a Red Clover Isoflavone, Combined with Progesterone Enhances PR Signaling through the Estrogen and Glucocorticoid Receptors

Autor: Julia R Austin, Joanna E. Burdette, Kailiang Li, Brian T. Murphy, Rocío Rivera Rodríguez, Daniel D. Lantvit

Publikováno v: J Nat Prod

Trifolium pratense L. (red clover) is a popular botanical supplement used for women's health. Irilone isolated from red clover previously demonstrated progestogenic potentiation activity. In this study, irilone enhanced progesterone signaling was det

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257506986ea06244ed98aebf9b21655d
https://pubmed.ncbi.nlm.nih.gov/34813298

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Irilone from Red Clover (Trifolium pratense) Potentiates Progesterone Signaling

Autor: Jung-Ho Lee, Joanna E. Burdette, Matthew Dean, Julia R Austin, Brian T. Murphy

Publikováno v: Journal of Natural Products. 81:1962-1967

The use of botanical dietary supplements is becoming increasingly popular for the alleviation of hormonal-based conditions such as hot flashes, premenstrual syndrome, and fertility. Estrogen and progesterone receptors (ER and PR) play an essential ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0feefdbc684cbfd29015384b25f8253b
https://doi.org/10.1021/acs.jnatprod.8b00131

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Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects

Autor: Yannan Li, Bao-Jing Zhang, Zhenlong Yu, Xiangge Tian, Lei Feng, Jing Ning, Yan Wang, Chao Wang, Cheng-Peng Sun, Xiaokui Huo, Xiaochi Ma

Publikováno v: Toxicology Letters. 294:27-36

The high risk of herb-drug interactions (HDIs) mediated by the herbal medicines and dietary supplements which containing abundant flavonoids had become more and more frequent in our daily life. In our study, the inhibition activities of 44 different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1363a12b10cf86201e2a7273bb1699f0
https://doi.org/10.1016/j.toxlet.2018.05.008

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Akademický článek

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Preparation of DESIGNER extracts of red clover (Trifolium pratense L.) by centrifugal partition chromatography

Autor: Shao-Nong Chen, J. Brent Friesen, Guido F. Pauli, David C. Lankin, Gonzalo R. Malca Garcia, Yang Liu, Dejan Nikolic, James B. McAlpine

Publikováno v: J Chromatogr A

Starting with an isoflavone-rich red clover extract (RCE), this study expands on the DESIGNER approach to Deplete and Enrich Select Ingredients to Generate Normalized Extract Resources using countercurrent separation (CCS) methodology. A hydrostatic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e0b62babf9882081c95e924e8af99f
https://pubmed.ncbi.nlm.nih.gov/31307793

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Phytochemical Analysis and Total Antioxidant Capacity of Rhizome, Above-Ground Vegetative Parts and Flower of Three Iris Species

Autor: Živoslav Lj. Tešić, Stevan Avramov, Miroljub B. Barać, Mirjana B. Pešić, Sladjana P. Stanojevic, Uroš Gašić, Aleksandar Ž. Kostić, Marina Mačukanović-Jocić

Publikováno v: Chemistry and Biodiversity
Chemistry & Biodiversity

This study was aimed at investigating the phytochemical composition and antioxidant capacity of rhizomes, above-ground vegetative parts and flowers of three Iris species: Iris humilis Georgi, Iris pumila L. and Iris variegata L. UHPLC-Orbitrap MS ana

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65f9800badcb784791ed6c7fce0db73f
https://cherry.chem.bg.ac.rs/handle/123456789/2872

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Phenolic compounds of Iris adriatica and their antimycobacterial effects

Autor: Krystyna Skalicka-Woźniak, Olaf Kunert, Ivan Duka, Simon Vlad Luca, Maria Ferreira Mourão, Stefanie Mayer, Fabian Alperth, Dario Hruševar, Ivana Turek, Željan Maleš, Franz Bucar, Sandra Ochensberger, Božena Mitić

Publikováno v: Acta Pharmaceutica
Volume 69
Issue 4
Acta Pharmaceutica, Vol 69, Iss 4, Pp 673-681 (2019)

Little is known about the pharmacological activities of Iris adriatica (Iridaceae), a plant endemic to Dalmatia (Croatia). We therefore performed a bioassay-guided fractionation including high-performance counter current chromatography (HPCCC) and an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a7802374700d0f314fcd0fac5ceae3
https://repozitorij.pharma.unizg.hr/islandora/object/pharma:1351/datastream/FILE0

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Mechanism of Action of Irilone as a Potentiator of Progesterone Receptor Signaling

Autor: Jeongho Lee, Brian T. Murphy, Joanna E. Burdette, Julia R Austin

Publikováno v: Journal of the Endocrine Society

Progesterone signaling and its proper regulation is important for reproductive function. When progesterone signaling is dysregulated, gynecological diseases can occur, for example endometriosis, uterine fibroids, and endometrial cancer. While these d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a89d3d61c363f25acba0e3e145c27a2
https://doi.org/10.1210/jendso/bvab048.1653

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