Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Irenej Kianicka"'
Autor:
Amanda Centorame, Daciana Catalina Dumut, Mina Youssef, Martin Ondra, Irenej Kianicka, Juhi Shah, Radu Alexandru Paun, Tomas Ozdian, John W. Hanrahan, Ekaterina Gusev, Basil Petrof, Marian Hajduch, Radu Pislariu, Juan Bautista De Sanctis, Danuta Radzioch
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Cystic fibrosis (CF) is the most common autosomal recessive genetic disease in Caucasians, affecting more than 100,000 individuals worldwide. It is caused by pathogenic variants in the gene encoding CFTR, an anion channel at the plasma membrane of ep
Externí odkaz:
https://doaj.org/article/e7cbeba9b2d34e6f99a2512513ff9ddf
Autor:
Louis-Etienne Lorenzo, Antoine G. Godin, Francesco Ferrini, Karine Bachand, Isabel Plasencia-Fernandez, Simon Labrecque, Alexandre A. Girard, Dominic Boudreau, Irenej Kianicka, Martin Gagnon, Nicolas Doyon, Alfredo Ribeiro-da-Silva, Yves De Koninck
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-23 (2020)
Disinhibition in the dorsal horn of the spinal cord may contribute to chronic pain. Here the authors show that, despite a paradoxical increase in α2/α3 subunits of the GABAA receptor in a neuropathic pain model, inhibition eventually fails due to K
Externí odkaz:
https://doaj.org/article/7e8316d0d5b2495c8bdcf34c648c6da7
Autor:
Abdelmadjid K. Hihi, Marie-Claude Beauchamp, Robyn Branicky, Annick Desjardins, Isabel Casanova, Marie-Pierre Guimond, Melissa Carroll, Melanie Ethier, Irenej Kianicka, Kevin McBride, Siegfried Hekimi
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 1, Pp 74-83 (2008)
Genetic analysis has shown that the slower than normal rhythmic defecation behavior of the clk-1 mutants of Caenorhabditis elegans is the result of altered lipoprotein metabolism. We show here that this phenotype can be suppressed by drugs that affec
Externí odkaz:
https://doaj.org/article/cf8edad76d314583a3b8faddda8b240e
Autor:
Martin Gagnon, Alexandre A. Girard, Antoine G. Godin, Yves De Koninck, Alfredo Ribeiro-da-Silva, Louis-Etienne Lorenzo, Francesco Ferrini, Isabel Plasencia-Fernandez, Simon Labrecque, Nicolas Doyon, Irenej Kianicka, Dominic Boudreau, Karine Bachand
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-23 (2020)
Spinal disinhibition has been hypothesized to underlie pain hypersensitivity in neuropathic pain. Apparently contradictory mechanisms have been reported, raising questions on the best target to produce analgesia. Here, we show that nerve injury is as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::994fd0e1744f15feeb46ff4d842b360b
http://hdl.handle.net/2318/1727795
http://hdl.handle.net/2318/1727795
Autor:
Louis-Etienne, Lorenzo, Antoine G, Godin, Francesco, Ferrini, Karine, Bachand, Isabel, Plasencia-Fernandez, Simon, Labrecque, Alexandre A, Girard, Dominic, Boudreau, Irenej, Kianicka, Martin, Gagnon, Nicolas, Doyon, Alfredo, Ribeiro-da-Silva, Yves, De Koninck
Publikováno v:
Nature Communications
Spinal disinhibition has been hypothesized to underlie pain hypersensitivity in neuropathic pain. Apparently contradictory mechanisms have been reported, raising questions on the best target to produce analgesia. Here, we show that nerve injury is as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8cb6e8982c3856c4d1139045d950da51
https://pubmed.ncbi.nlm.nih.gov/32054836
https://pubmed.ncbi.nlm.nih.gov/32054836
Autor:
Paul Isenring, Mariève Jacob-Wagner, Marc J. Bergeron, Jeffrey A. M. Coull, Guillaume Lavertu, Lionel Dumas, Sasmita Tripathy, Giorgio Attardo, Annie Castonguay, Irenej Kianicka, Christian Tardif, Karine Bachand, Robert P. Bonin, Martin Gagnon, Jimena Perez-Sanchez, Yves De Koninck, Bin Wang, Isabelle Valade, Dominic Boudreau
Publikováno v:
Nature Medicine. 19:1524-1528
The K(+)-Cl(-) cotransporter KCC2 is responsible for maintaining low Cl(-) concentration in neurons of the central nervous system (CNS), which is essential for postsynaptic inhibition through GABA(A) and glycine receptors. Although no CNS disorders h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6775e4833793b5f96edcd0fe890f15f6
https://doi.org/10.1038/nm.3356
https://doi.org/10.1038/nm.3356
Autor:
Marie-Pierre Guimond, Melissa Carroll, Kevin M. McBride, Siegfried Hekimi, Marie-Claude Beauchamp, Abdelmadjid K. Hihi, Annick Desjardins, Isabel Casanova, Melanie Ethier, Robyn Branicky, Irenej Kianicka
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 1, Pp 74-83 (2008)
Genetic analysis has shown that the slower than normal rhythmic defecation behavior of the clk-1 mutants of Caenorhabditis elegans is the result of altered lipoprotein metabolism. We show here that this phenotype can be suppressed by drugs that affec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e41dd43001fc5308d569f60000978ee
http://www.sciencedirect.com/science/article/pii/S0022227520428822
http://www.sciencedirect.com/science/article/pii/S0022227520428822
Autor:
Henriette Gourdeau, Lorraine Leblond, Bettina Hamelin, Clemence Desputeau, Kelly Dong, Irenej Kianicka, Dominique Custeau, Chantal Boudreau, Lilianne Geerts, Sui-Xiong Cai, John Drewe, Denis Labrecque, Shailaja Kasibhatla, Ben Tseng
Publikováno v:
Molecular Cancer Therapeutics. 3:1375-1384
A novel series of 2-amino-4-(3-bromo-4,5-dimethoxy-phenyl)-3-cyano-4H-chromenes was identified as potent apoptosis inducers through a cell-based high throughput screening assay. Six compounds from this series, MX-58151, MX-58276, MX-76747, MX-116214,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84b8df55ad4d1b0e77e932e397bb8d1f
https://doi.org/10.1158/1535-7163.1375.3.11
https://doi.org/10.1158/1535-7163.1375.3.11
Autor:
Sylvain Renolleau, Jean-Paul Praud, Irenej Kianicka, Patrick Létourneau, Véronique Diaz, Dominique Dorion
Publikováno v:
Journal of Applied Physiology. 86:1570-1577
The present study, performed in nonsedated, conscious lambs, consisted of two parts. In the first part, we 1) examined for the first time whether a respiratory response to pulmonary C-fiber stimulation could be elicited in nonsedated newborns and 2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd85c5f0cbbf8c246c8035ab979dfe5c
https://doi.org/10.1152/jappl.1999.86.5.1570
https://doi.org/10.1152/jappl.1999.86.5.1570
Publikováno v:
Journal of Applied Physiology. 86:1561-1569
The present study was undertaken to gain further insight into the mechanisms responsible for the sustained active expiratory upper airway closure previously observed during high-permeability pulmonary edema in lambs. The experiments were conducted in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65710376923f051eef96fa9c1a1aac90
https://doi.org/10.1152/jappl.1999.86.5.1561
https://doi.org/10.1152/jappl.1999.86.5.1561