Sex differences in the effectiveness of first-line tumour necrosis factor inhibitors in axial spondyloarthritis: results from the EuroSpA Research Collaboration Network

Autor: Ronald F van Vollenhoven, Bente Glintborg, Merete Lund Hetland, Ulf Lindström, Brigitte Michelsen, Elsa Vieira-Sousa, Florenzo Iannone, Eirik Klami Kristianslund, Dan Nordström, Karel Pavelka, Ziga Rotar, Maria Jose Santos, Catalin Codreanu, Gary J Macfarlane, Mikkel Østergaard, Michael T Nurmohamed, Jiri Vencovsky, Rosario Foti, Bjorn Gudbjornsson, Matija Tomšič, Lykke Midtbøll Ørnbjerg, Adrian Ciurea, Árni Jón Geirsson, Irene van der Horst-Bruinsma, Michael S Nissen, Ovidiu Rotariu, Isabel Castrejón, Johan K Wallman, Marleen van de Sande, Anne G Loft, Pasoon Hellamand, Thomas Klausch, Anna Mari Hokkanen, Corina Mogosan, Lucia Otero-Varela, Semih Gulle, Berrin Zengin

Publikováno v: RMD Open, Vol 9, Iss 4 (2023)

Objective Evidence indicates reduced treatment effectiveness of TNFi in women with axial spondyloarthritis (axSpA) compared with men. We aimed to investigate sex differences in treatment response and retention rates over 24 months of follow-up in axS

Externí odkaz: https://doaj.org/article/e6632f400b4e4c9eb966b1dc4cf15287

Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis

Autor: Kazuyoshi, Ishigaki, Saori, Sakaue, Chikashi, Terao, Yang, Luo, Kyuto, Sonehara, Kensuke, Yamaguchi, Tiffany, Amariuta, Chun Lai, Too, Vincent A, Laufer, Ian C, Scott, Sebastien, Viatte, Meiko, Takahashi, Koichiro, Ohmura, Akira, Murasawa, Motomu, Hashimoto, Hiromu, Ito, Mohammed, Hammoudeh, Samar Al, Emadi, Basel K, Masri, Hussein, Halabi, Humeira, Badsha, Imad W, Uthman, Xin, Wu, Li, Lin, Ting, Li, Darren, Plant, Anne, Barton, Gisela, Orozco, Suzanne M M, Verstappen, John, Bowes, Alexander J, MacGregor, Suguru, Honda, Masaru, Koido, Kohei, Tomizuka, Yoichiro, Kamatani, Hiroaki, Tanaka, Eiichi, Tanaka, Akari, Suzuki, Yuichi, Maeda, Kenichi, Yamamoto, Satoru, Miyawaki, Gang, Xie, Jinyi, Zhang, Christopher I, Amos, Edward, Keystone, Gertjan, Wolbink, Irene, van der Horst-Bruinsma, Jing, Cui, Katherine P, Liao, Robert J, Carroll, Hye-Soon, Lee, So-Young, Bang, Katherine A, Siminovitch, Niek, de Vries, Lars, Alfredsson, Solbritt, Rantapää-Dahlqvist, Elizabeth W, Karlson, Sang-Cheol, Bae, Robert P, Kimberly, Jeffrey C, Edberg, Xavier, Mariette, Tom, Huizinga, Philippe, Dieudé, Matthias, Schneider, Martin, Kerick, Joshua C, Denny, Koichi, Matsuda, Keitaro, Matsuo, Tsuneyo, Mimori, Fumihiko, Matsuda, Keishi, Fujio, Yoshiya, Tanaka, Atsushi, Kumanogoh, Matthew, Traylor, Cathryn M, Lewis, Stephen, Eyre, Huji, Xu, Richa, Saxena, Thurayya, Arayssi, Yuta, Kochi, Katsunori, Ikari, Masayoshi, Harigai, Peter K, Gregersen, Kazuhiko, Yamamoto, S, Louis Bridges, Leonid, Padyukov, Javier, Martin, Lars, Klareskog, Yukinori, Okada, Soumya, Raychaudhuri

Publikováno v: Nature Genetics, 54, 1640-1651
The Biobank Japan Project 2022, ' Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis ', Nature Genetics, vol. 54, no. 11, pp. 1640-1651 . https://doi.org/10.1038/s41588-022-01213-w
Nature genetics, 54(11), 1640-1651. Nature Publishing Group
Nature Genetics, 54(11), 1640-+. NATURE PORTFOLIO
Nature Genetics, 54(11), 1640-1651. Nature Publishing Group
Nature Genetics, 54, 11, pp. 1640-1651
Nat Genet

Multi-ancestry genome-wide association analyses identify 124 risk loci for rheumatoid arthritis, of which 34 are novel. A polygenic risk score based on multi-ancestry data showed comparable performance between populations of European and East Asian a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e48733cf2e8205acbde830a39b0265
https://doi.org/10.1038/s41588-022-01213-w

Treatment decisions in axial spondyloarthritis daily clinical practice are more than treat-to-target

Autor: Janne W Bolt, Caroline J Aalbers, Laura Walet, Leonieke J J van Mens, Christiaan van Denderen, Irene van der Horst-Bruinsma, Lisa G M van Baarsen, Robert Landewé, Marleen G H van de Sande

Publikováno v: Rheumatology.

Objective ‘Treat-to-target principles’ are advised for axial spondyloarthritis (axSpA), although a clear target is not yet defined and targets do not always reflect inflammation. Treat-to-target use and motives for treatment choices in clinics ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5417805e2d260cf7c6f0e43e79f7275f
https://doi.org/10.1093/rheumatology/kead155

European bio-naïve spondyloarthritis patients initiating TNF inhibitor: time trends in baseline characteristics, treatment retention and response

Autor: Sara Nysom Christiansen, Lykke Midtbøll Ørnbjerg, Simon Horskjær Rasmussen, Anne Gitte Loft, Johan Askling, Florenzo Iannone, Jakub Zavada, Brigitte Michelsen, Michael Nissen, Fatos Onen, Maria Jose Santos, Manuel Pombo-Suarez, Heikki Relas, Gary J Macfarlane, Matija Tomsic, Catalin Codreanu, Bjorn Gudbjornsson, Irene Van der Horst-Bruinsma, Daniela Di Giuseppe, Bente Glintborg, Elisa Gremese, Karel Pavelka, Eirik Klami Kristianslund, Adrian Ciurea, Nurullah Akkoc, Anabela Barcelos, Carlos Sánchez-Piedra, Ritva Peltomaa, Gareth T Jones, Ziga Rotar, Ruxandra Ionescu, Gerdur Grondal, Marleen G H Van de Sande, Karin Laas, Mikkel Østergaard, Merete L Hetland

Publikováno v: Christiansen, S N, Ørnbjerg, L M, Rasmussen, S H, Loft, A G, Askling, J, Iannone, F, Zavada, J, Michelsen, B, Nissen, M, Onen, F, Santos, M J, Pombo-Suarez, M, Relas, H, Macfarlane, G J, Tomsic, M, Codreanu, C, Gudbjornsson, B, van der Horst-Bruinsma, I, di Giuseppe, D, Glintborg, B, Gremese, E, Pavelka, K, Kristianslund, E K, Ciurea, A, Akkoc, N, Barcelos, A, Sánchez-Piedra, C, Peltomaa, R, Jones, G T, Rotar, Z, Ionescu, R, Grondal, G, van de Sande, M G H, Laas, K, Østergaard, M & Hetland, M L 2022, ' European bio-naïve spondyloarthritis patients initiating TNF inhibitor : time trends in baseline characteristics, treatment retention and response ', Rheumatology (Oxford, England), vol. 61, no. 9, pp. 3799-3807 . https://doi.org/10.1093/rheumatology/keab945
Rheumatology, 61, 9, pp. 3799-3807
Rheumatology (Oxford, England), 61(9), 3799-3807. Oxford University Press
Rheumatology, 61, 3799-3807
Christiansen, S N, Ørnbjerg, L M, Rasmussen, S H, Loft, A G, Askling, J, Iannone, F, Zavada, J, Michelsen, B, Nissen, M, Onen, F, Santos, M J, Pombo-Suarez, M, Relas, H, Macfarlane, G J, Tomsic, M, Codreanu, C, Gudbjornsson, B, Van der Horst-Bruinsma, I, Di Giuseppe, D, Glintborg, B, Gremese, E, Pavelka, K, Kristianslund, E K, Ciurea, A, Akkoc, N, Barcelos, A, Sánchez-Piedra, C, Peltomaa, R, Jones, G T, Rotar, Z, Ionescu, R, Grondal, G, Van de Sande, M G H, Laas, K, Østergaard, M & Hetland, M L 2022, ' European bio-naïve spondyloarthritis patients initiating TNF inhibitor : time trends in baseline characteristics, treatment retention and response ', Rheumatology (Oxford, England), vol. 61, no. 9, pp. 3799-3807 . https://doi.org/10.1093/rheumatology/keab945
Rheumatology (2021) P. keab945

Objectives To investigate time trends in baseline characteristics and retention, remission and response rates in bio-naïve axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) patients initiating TNF inhibitor (TNFi) treatment. Methods Pros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a039ee4942fd692a4debb118267abb
https://doi.org/10.1093/rheumatology/keab945

Does gender modify outcome in rheumatic diseases?

Autor: Irene Van der Horst-Bruinsma

Publikováno v: Joint Bone Spine, 89(3):105365. Elsevier Masson
van der Horst-Bruinsma, I E 2022, ' Does gender modify outcome in rheumatic diseases? ', Joint Bone Spine, vol. 89, no. 3, 105365 . https://doi.org/10.1016/j.jbspin.2022.105365
Joint Bone Spine, 89, 3
Joint Bone Spine, 89

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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32af327bad8c170ff7d6a3f30c117046
https://doi.org/10.1016/j.jbspin.2022.105365