Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Irene Zagol-Ikapitte"'
Autor:
Huan Tao, Jiansheng Huang, Patricia G. Yancey, Valery Yermalitsky, John L. Blakemore, Youmin Zhang, Lei Ding, Irene Zagol-Ikapitte, Fei Ye, Venkataraman Amarnath, Olivier Boutaud, John A. Oates, L. Jackson Roberts, Sean S. Davies, MacRae F. Linton
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Hypercholesterolemia is associated with lipid peroxidation induced reactive dicarbonyl adducts. Here the authors show that the dicarbonyl scavenger, 2-hydroxybenzylamine(2-HOBA), decreases reactive dicarbonyl modifications of LDL and HDL, improves HD
Externí odkaz:
https://doaj.org/article/1e1c9269b742425ab2397a10869c4faa
Autor:
Venkataraman Amarnath, Irene Zagol-Ikapitte, Alexander Panov, Anna Dikalova, Aurelia Vergeade, Frederic T. Billings, Liang Xiao, David G. Harrison, Sean S. Davies, Olivier Boutaud, Rafal R. Nazarewicz, L. Jackson Roberts, Sergey Dikalov, Valery Yermalitsky, Marcos G. Lopez, Mingfang Ao, Vladimir Mayorov
Publikováno v:
Hypertension
Hypertension remains a major health problem in Western Societies, and blood pressure is poorly controlled in a third of patients despite use of multiple drugs. Mitochondrial dysfunction contributes to hypertension, and mitochondria-targeted agents ca
Autor:
Anna Dikalova, Vladimir Mayorov, Liang Xiao, Alexander Panov, Venkataraman Amarnath, Irene Zagol-Ikapitte, Aurelia Vergeade, Mingfang Ao, Valery Yermalitsky, Rafal Nazarewicz, Olivier Boutaud, Marcos G Lopez, Frederic T Billings, Sean S Davies, L. Jackson Roberts, David G Harrison, Sergey I Dikalov
Publikováno v:
Hypertension. 76
Hypertension remains a major health problem in Western Societies, and blood pressure is poorly controlled in a third of patients despite use of multiple drugs. Mitochondrial dysfunction contributes to hypertension and mitochondria-targeted agents can
Autor:
Patricia G. Yancey, Huan Tao, Jiansheng Huang, Lei Ding, Venkataraman Amarnath, Fei Ye, John L. Blakemore, John A. Oates, Sean S. Davies, L. Jackson Roberts, Valery Yermalitsky, Irene Zagol-Ikapitte, MacRae F. Linton, Olivier Boutaud, Youmin Zhang
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Lipid peroxidation generates reactive dicarbonyls including isolevuglandins (IsoLGs) and malondialdehyde (MDA) that covalently modify proteins. Humans with familial hypercholesterolemia (FH) have increased lipoprotein dicarbonyl adducts and dysfuncti
Autor:
Sean S. Davies, Prince J. Kannankeril, Joshua M. Stark, James M. Luther, Annet Kirabo, Isis L Christopher, Meena S. Madhur, James B. Atkinson, Irene Zagol-Ikapitte, Liudmila V. Yermalitskaya, Scott R. Jafarian-Kerman, Matthew B Murphy, Agnes B. Fogo, David G. Harrison, Katherine T. Murray, Mohamed A. Saleh, Joey V. Barnett, Olivier Boutaud, Roxana Loperena, Joseph K. Prinsen, Venkataraman Amarnath, Tatiana N. Sidorova, Allison E. Norlander, Tuerdi Subati
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • IsoLGs are highly reactive lipid dicarbonyl metabolites that constitute a major component of oxidative stress-related injury, and they promote the formation of amyloid. • In a hypertensive murine model, IsoLG add
Highlights • IsoLGs are highly reactive lipid dicarbonyl metabolites that constitute a major component of oxidative stress-related injury, and they promote the formation of amyloid. • In a hypertensive murine model, IsoLG add
Autor:
Irene Zagol-Ikapitte, Huan Tao, Lei Ding, John A. Oates, Valery Yermalitsky, John L. Blakemore, Olivier Boutaud, Sean S. Davies, Jiansheng Huang, Venkataraman Amarnath, Patricia G. Yancey, L. Jackson Roberts, MacRae F. Linton, Youmin Zhang
The pathogenesis of atherosclerosis may be accelerated by oxidative stress, which produces lipid peroxidation. Among the products of lipid peroxidation are highly reactive dicarbonyls including isolevuglandins (IsoLGs) and malondialdehyde (MDA) that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31fe5c561ed163416c08fa76513497ec
https://doi.org/10.1101/524884
https://doi.org/10.1101/524884
Autor:
Alberto G. Delgado, Jordan L. Finley, Diane Bimczok, Kara M. McNamara, Margaret M. Allaman, Thomas G. Verriere, Keith T. Wilson, Olivier Boutaud, Mohammad Asim, M. Kay Washington, Mohammed N. Tantawy, M. Blanca Piazuelo, Shilin Zhao, Irene Zagol-Ikapitte, Daniel P. Barry, Lori A. Coburn, Alain P. Gobert, Yvonne L. Latour, Johanna C. Sierra, Venkataraman Amarnath, Kshipra Singh
Publikováno v:
Gastroenterology
Background & Aims Inflammation in the gastrointestinal tract may lead to the development of cancer. Dicarbonyl electrophiles, such as isolevuglandins (isoLGs), are generated from lipid peroxidation during the inflammatory response and form covalent a
Autor:
Philip J. Kingsley, Irene Zagol-Ikapitte, Orrette R. Wauchope, Steven M. Shell, Walter J. Chazin, James J. Galligan, Carol A. Rouzer, William N. Beavers, John A. Oates, Olivier Boutaud, Norie Sugitani, Lawrence J. Marnett, Sarah C. Shuck, Kristie L. Rose
Publikováno v:
Chemical Research in Toxicology
Base propenals are products of the reaction of DNA with oxidants such as peroxynitrite and bleomycin. The most reactive base propenal, adenine propenal, is mutagenic in Escherichia coli and reacts with DNA to form covalent adducts; however, the react
Autor:
Erica J. Carrier, Venkataraman Amarnath, Olivier Boutaud, Irene Zagol-Ikapitte, John A. Oates
Publikováno v:
Biochemistry
Inflammation and subsequent cyclooxygenase-2 (COX-2) activity has long been linked with the development of cancer, although little is known about any epigenetic effects of COX-2. A product of COX-2 activation, levuglandin (LG) quickly forms covalent
Autor:
Ravindran Caspa Gokulan, Irene Zagol-Ikapitte, Johns A. Oates, Sergey Dikalov, Elena Zaika, Wael El-Rifai, Manikandan Palrasu, Olivier Boutaud, Alexander Zaika
Publikováno v:
Gastroenterology. 156:S-291