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pro vyhledávání: '"Irene Weiner"'
Autor:
Reiner Meyer, Heribert Arnhof, Daniela Haering, Rachel L Mendes, David J. Richard, Irene Weiner, Norbert Kraut, Wolfgang Hela, Christian Salamon, Klaus Rumpel, Gerd Bader, Michael Gmachl, Andreas Dr. Zöphel, Renate Schnitzer, Peter Ettmayer, Jark Böttcher, Matthew D Kennedy, Juergen Ramharter, Michael P. Sanderson, Darryl B. McConnell, Nikolai Pototschnig, Dirk Kessler, Silvia Munico-Martinez, Tobias Wunberg, Marco H. Hofmann, Katja Hauer, Thomas Gerstberger, Lyne Lamarre, Patrick Werni, Christiane Kofink, Jonathan O’Connell, Bernhard Wolkerstorfer
Publikováno v:
Journal of medicinal chemistry. 64(10)
KRAS, the most common oncogenic driver in human cancers, is controlled and signals primarily through protein-protein interactions (PPIs). The interaction between KRAS and SOS1, crucial for the activation of KRAS, is a typical, challenging PPI with a