Výsledky vyhledávání - "Irene W. Althaus"

Akademický článek

Contribution of a Single Host Genetic Locus to Mouse Adenovirus Type 1 Infection and Encephalitis

Autor: Tien-Huei Hsu, Irene W. Althaus, Oded Foreman, Katherine R. Spindler

Publikováno v: mBio, Vol 3, Iss 3 (2012)

ABSTRACT Susceptibility to mouse adenovirus type 1 (MAV-1) is mouse strain dependent; susceptible mice die from hemorrhagic encephalomyelitis. The MAV-1 susceptibility quantitative trait locus Msq1 accounts for ~40% of the phenotypic (brain viral loa

Externí odkaz: https://doaj.org/article/ac1dd438e77841fd8a122f0395f1ac8a

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Supplementary Fig. S3 from Antitumor activity and pharmacokinetic properties of PF-00299804, a second-generation irreversible pan-erbB receptor tyrosine kinase inhibitor

Supplementary Fig. S3 from Antitumor activity and pharmacokinetic properties of PF-00299804, a second-generation irreversible pan-erbB receptor tyrosine kinase inhibitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a40c0cb9dee2febea61bbf447bdf801
https://doi.org/10.1158/1535-7163.22483889

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Data from Antitumor activity and pharmacokinetic properties of PF-00299804, a second-generation irreversible pan-erbB receptor tyrosine kinase inhibitor

Signaling through the erbB receptor family of tyrosine kinases contributes to the proliferation, differentiation, migration, and survival of a variety of cell types. Abnormalities in members of this receptor family have been shown to play a role in o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1992a9e6a0fff9d2a73c053cb1cf91a6
https://doi.org/10.1158/1535-7163.c.6531266.v1

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Supplementary Table 1 from PF00299804, an Irreversible Pan-ERBB Inhibitor, Is Effective in Lung Cancer Models with EGFR and ERBB2 Mutations that Are Resistant to Gefitinib

Autor: Pasi A. Jänne, Kwok-Kin Wong, Matthew Meyerson, John V. Heymach, James M. Nelson, Geoffrey I. Shapiro, Leena Gandhi, Irene W. Althaus, James E. Bradner, George N. Naumov, Patrick W. Vincent, Feng Zhao, Takeshi Shimamura, Andrea J. Gonzales, Eugene Lifshits, Christopher-Michael Gale, Kreshnik Zejnullahu, Jeffrey A. Engelman

Supplementary Table 1 from PF00299804, an Irreversible Pan-ERBB Inhibitor, Is Effective in Lung Cancer Models with EGFR and ERBB2 Mutations that Are Resistant to Gefitinib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6c0ed7094f35e06853396808bc4bc65
https://doi.org/10.1158/0008-5472.22370564.v1

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Data from PF00299804, an Irreversible Pan-ERBB Inhibitor, Is Effective in Lung Cancer Models with EGFR and ERBB2 Mutations that Are Resistant to Gefitinib

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors gefitinib and erlotinib are effective treatments for a subset of non–small cell lung cancers. In particular, cancers with specific EGFR-activating mutations seem to be the most sens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c24e94b1432d71a7047c9e0610b8a6
https://doi.org/10.1158/0008-5472.c.6496436

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Tyrosine Kinase Inhibitors. 20. Optimization of Substituted Quinazoline and Pyrido[3,4-d]pyrimidine Derivatives as Orally Active, Irreversible Inhibitors of the Epidermal Growth Factor Receptor Family

Publikováno v: Journal of Medicinal Chemistry. 59:8103-8124

Structure-activity relationships for inhibition of erbB1, erbB2, and erbB4 were determined for a series of quinazoline- and pyrido[3,4-d]pyrimidine-based analogues of the irreversible pan-erbB inhibitor, canertinib. Cyclic amine bearing crotonamides

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e41b02b5002130f3f1a0856c03fbdf
https://doi.org/10.1021/acs.jmedchem.6b00883

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The Major Locus for Mouse Adenovirus Susceptibility Maps to Genes of the Hematopoietic Cell Surface-Expressed LY6 Family

Autor: Jennifer E. Imperiale, Efrem S. Lim, Amanda R. Welton, Suman Duvvuru, Irene W. Althaus, Katherine R. Spindler, Elissa J. Chesler, Adam I. Daoud

Publikováno v: The Journal of Immunology. 184:3055-3062

Susceptibility to mouse adenovirus type 1 is associated with the major quantitative trait locus Msq1. Msq1 was originally mapped to a 13-Mb region of mouse chromosome (Chr) 15 in crosses between SJL/J and BALB/cJ inbred mice. We have now narrowed Msq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a87d48bbe4051a7dccae3579d82f0ec2
https://doi.org/10.4049/jimmunol.0903363

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Tyrosine Kinase Inhibitors. 19. 6-Alkynamides of 4-Anilinoquinazolines and 4-Anilinopyrido[3,4-d]pyrimidines as Irreversible Inhibitors of the erbB Family of Tyrosine Kinase Receptors

Publikováno v: Journal of Medicinal Chemistry. 49:1475-1485

Structure-activity relationships for inhibition of erbB1, erbB2, and erbB4 were determined for a series of alkynamide analogues of quinazoline- and pyrido[3,4-d]pyrimidine-based compounds. The compounds were prepared by coupling the appropriate 6-ami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21abfede32f22f167677e3f652089d6a
https://doi.org/10.1021/jm050936o

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Ihog and Boi elicit Hh signaling via Ptc but do not aid Ptc in sequestering the Hh ligand

Autor: Alexander M. Holtz, Billy Haitian He, Irene W. Althaus, Freédéric Charron, Sally Li, Donald J van Meyel, Benjamin L. Allen, Darius Camp

Publikováno v: Development (Cambridge, England). 141(20)

Hedgehog (Hh) proteins are secreted molecules essential for tissue development in vertebrates and invertebrates. Hh reception via the 12-pass transmembrane protein Patched (Ptc) elicits intracellular signaling through Smoothened (Smo). Hh binding to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952bd87371158aae3dc7ee0539a9d915
https://pubmed.ncbi.nlm.nih.gov/25231763

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Novenamines as inhibitors of two independent enzymes during DNA replication in a toluenized Escherichia coli cell system

Autor: Fritz Reusser, Irene W. Althaus, Charles H. Spilman, Ferenc J. Kezdy, T. Peterson

Publikováno v: Biochemical Pharmacology. 51:1373-1378

The amphiphilic novenamines described in this report have been shown previously to be specific inhibitors of human immunodeficiency virus type 1 reverse transcriptase-associated ribonuclease, which they inhibit when they are in the micellar state but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d4c3cd4991f4c8721c3dcfe6f5585e
https://doi.org/10.1016/0006-2952(96)00061-5

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