Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Irene W. Althaus"'
Autor:
Patrick W. Vincent, Haile Tecle, Helen T. Lee, Jianxin Yang, Deborah A. Baker, Daniel J. Lettiere, Alex J. Bridges, Jessica E. Reed, R. Thomas Winters, Karen E. Sexton, Kevin M. Schlosser, Stephen A. Fakhoury, Cho-Ming Loi, Tong Zhu, David W. Fry, James M. Nelson, Danielle M. Amato, Teresa A. Ellis, Patricia J. Harvey, Amy M. Delaney, Erin Trachet, Paul A. Ellis, Irene W. Althaus, Kenneth E. Hook, Andrea J. Gonzales
Supplementary Fig. S3 from Antitumor activity and pharmacokinetic properties of PF-00299804, a second-generation irreversible pan-erbB receptor tyrosine kinase inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a40c0cb9dee2febea61bbf447bdf801
https://doi.org/10.1158/1535-7163.22483889
https://doi.org/10.1158/1535-7163.22483889
Autor:
Patrick W. Vincent, Haile Tecle, Helen T. Lee, Jianxin Yang, Deborah A. Baker, Daniel J. Lettiere, Alex J. Bridges, Jessica E. Reed, R. Thomas Winters, Karen E. Sexton, Kevin M. Schlosser, Stephen A. Fakhoury, Cho-Ming Loi, Tong Zhu, David W. Fry, James M. Nelson, Danielle M. Amato, Teresa A. Ellis, Patricia J. Harvey, Amy M. Delaney, Erin Trachet, Paul A. Ellis, Irene W. Althaus, Kenneth E. Hook, Andrea J. Gonzales
Signaling through the erbB receptor family of tyrosine kinases contributes to the proliferation, differentiation, migration, and survival of a variety of cell types. Abnormalities in members of this receptor family have been shown to play a role in o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1992a9e6a0fff9d2a73c053cb1cf91a6
https://doi.org/10.1158/1535-7163.c.6531266.v1
https://doi.org/10.1158/1535-7163.c.6531266.v1
Autor:
Pasi A. Jänne, Kwok-Kin Wong, Matthew Meyerson, John V. Heymach, James M. Nelson, Geoffrey I. Shapiro, Leena Gandhi, Irene W. Althaus, James E. Bradner, George N. Naumov, Patrick W. Vincent, Feng Zhao, Takeshi Shimamura, Andrea J. Gonzales, Eugene Lifshits, Christopher-Michael Gale, Kreshnik Zejnullahu, Jeffrey A. Engelman
Supplementary Table 1 from PF00299804, an Irreversible Pan-ERBB Inhibitor, Is Effective in Lung Cancer Models with EGFR and ERBB2 Mutations that Are Resistant to Gefitinib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6c0ed7094f35e06853396808bc4bc65
https://doi.org/10.1158/0008-5472.22370564.v1
https://doi.org/10.1158/0008-5472.22370564.v1
Autor:
Pasi A. Jänne, Kwok-Kin Wong, Matthew Meyerson, John V. Heymach, James M. Nelson, Geoffrey I. Shapiro, Leena Gandhi, Irene W. Althaus, James E. Bradner, George N. Naumov, Patrick W. Vincent, Feng Zhao, Takeshi Shimamura, Andrea J. Gonzales, Eugene Lifshits, Christopher-Michael Gale, Kreshnik Zejnullahu, Jeffrey A. Engelman
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors gefitinib and erlotinib are effective treatments for a subset of non–small cell lung cancers. In particular, cancers with specific EGFR-activating mutations seem to be the most sens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c24e94b1432d71a7047c9e0610b8a6
https://doi.org/10.1158/0008-5472.c.6496436
https://doi.org/10.1158/0008-5472.c.6496436
Publikováno v:
mBio, Vol 3, Iss 3 (2012)
ABSTRACT Susceptibility to mouse adenovirus type 1 (MAV-1) is mouse strain dependent; susceptible mice die from hemorrhagic encephalomyelitis. The MAV-1 susceptibility quantitative trait locus Msq1 accounts for ~40% of the phenotypic (brain viral loa
Externí odkaz:
https://doaj.org/article/ac1dd438e77841fd8a122f0395f1ac8a
Autor:
Patricia J. Harvey, Gonzales Andrea, Shannon Leigh Black, Jeff B. Smaill, Ken Hook, Florence O. McCarthy, Stephen Fakhoury, Adrian Blaser, Haile Tecle, Freddy Rivault, Tong Zhu, Brian D. Palmer, Kevin Matthew Schlosser, Jessica Elizabeth Reed, Karen Elaine Sexton, William A. Denny, Irene W. Althaus, R. Thomas Winters, Teresa Ellis, Helen Tsenwhei Lee, Andrew M. Thompson, Erin Trachet, Alexander James Bridges, Julie Ann Spicer, Paul A. Ellis
Publikováno v:
Journal of Medicinal Chemistry. 59:8103-8124
Structure-activity relationships for inhibition of erbB1, erbB2, and erbB4 were determined for a series of quinazoline- and pyrido[3,4-d]pyrimidine-based analogues of the irreversible pan-erbB inhibitor, canertinib. Cyclic amine bearing crotonamides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e41b02b5002130f3f1a0856c03fbdf
https://doi.org/10.1021/acs.jmedchem.6b00883
https://doi.org/10.1021/acs.jmedchem.6b00883
Autor:
Jennifer E. Imperiale, Efrem S. Lim, Amanda R. Welton, Suman Duvvuru, Irene W. Althaus, Katherine R. Spindler, Elissa J. Chesler, Adam I. Daoud
Publikováno v:
The Journal of Immunology. 184:3055-3062
Susceptibility to mouse adenovirus type 1 is associated with the major quantitative trait locus Msq1. Msq1 was originally mapped to a 13-Mb region of mouse chromosome (Chr) 15 in crosses between SJL/J and BALB/cJ inbred mice. We have now narrowed Msq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a87d48bbe4051a7dccae3579d82f0ec2
https://doi.org/10.4049/jimmunol.0903363
https://doi.org/10.4049/jimmunol.0903363
Autor:
James M. Nelson, Danielle M. Amato, William A. Denny, Patricia J. Harvey, Veronica Sherwood, R. Thomas Winters, David W. Fry, Sylvester R. Klutchko, Jeff B. Smaill, Zhou Hairong, Paul A. Ellis, Hyo Kyung Han, Mary Ann Meade, Gerry Pace, H. D. Hollis Showalter, Tuan P. Tran, William L. Elliott, Billy J. Roberts, Irene W. Althaus, Alexander James Bridges, Andrea J. Gonzales
Publikováno v:
Journal of Medicinal Chemistry. 49:1475-1485
Structure-activity relationships for inhibition of erbB1, erbB2, and erbB4 were determined for a series of alkynamide analogues of quinazoline- and pyrido[3,4-d]pyrimidine-based compounds. The compounds were prepared by coupling the appropriate 6-ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21abfede32f22f167677e3f652089d6a
https://doi.org/10.1021/jm050936o
https://doi.org/10.1021/jm050936o
Autor:
Alexander M. Holtz, Billy Haitian He, Irene W. Althaus, Freédéric Charron, Sally Li, Donald J van Meyel, Benjamin L. Allen, Darius Camp
Publikováno v:
Development (Cambridge, England). 141(20)
Hedgehog (Hh) proteins are secreted molecules essential for tissue development in vertebrates and invertebrates. Hh reception via the 12-pass transmembrane protein Patched (Ptc) elicits intracellular signaling through Smoothened (Smo). Hh binding to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952bd87371158aae3dc7ee0539a9d915
https://pubmed.ncbi.nlm.nih.gov/25231763
https://pubmed.ncbi.nlm.nih.gov/25231763
Publikováno v:
Biochemical Pharmacology. 51:1373-1378
The amphiphilic novenamines described in this report have been shown previously to be specific inhibitors of human immunodeficiency virus type 1 reverse transcriptase-associated ribonuclease, which they inhibit when they are in the micellar state but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d4c3cd4991f4c8721c3dcfe6f5585e
https://doi.org/10.1016/0006-2952(96)00061-5
https://doi.org/10.1016/0006-2952(96)00061-5