Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Irene Simkin"'
Autor:
Madeline Ally, Michael A. Sugarman, Henrik Zetterberg, Kaj Blennow, Nicholas J. Ashton, Thomas K. Karikari, Hugo J. Aparicio, Brandon Frank, Yorghos Tripodis, Brett Martin, Joseph N. Palmisano, Eric G. Steinberg, Irene Simkin, Lindsay A. Farrer, Gyungah R. Jun, Katherine W. Turk, Andrew E. Budson, Maureen K. O'Connor, Rhoda Au, Lee E. Goldstein, Neil W. Kowall, Ronald Killiany, Robert A. Stern, Thor D. Stein, Ann C. McKee, Wei Qiao Qiu, Jesse Mez, Michael L. Alosco
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 4, Pp n/a-n/a (2023)
Abstract Introduction This study examined plasma glial fibrillary acidic protein (GFAP) as a biomarker of cognitive impairment due to Alzheimer's disease (AD) with and against plasma neurofilament light chain (NfL), and phosphorylated tau (p‐tau)18
Externí odkaz:
https://doaj.org/article/ff11c458cac94bb4a7cf517d4897d352
Autor:
James D. Griffin, Marion Wiesmann, Sean M. McDonough, Jens U. Wuerthner, Sebastien Jeay, Martin Sattler, Erik Nelson, Kristen Cowens, Ilene Galinsky, Richard Stone, Moriko Ito, Louise Barys, Brandon Antonakos, Jing Yuan, Irene Simkin, Takaomi Sanda, Tao Ren, Atsushi Nonami, Vesselina G. Cooke, Ensar Halilovic, Ellen Weisberg
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77652698c8f5e96ead4e624b606e372c
https://doi.org/10.1158/1535-7163.22506793
https://doi.org/10.1158/1535-7163.22506793
Autor:
James D. Griffin, Marion Wiesmann, Sean M. McDonough, Jens U. Wuerthner, Sebastien Jeay, Martin Sattler, Erik Nelson, Kristen Cowens, Ilene Galinsky, Richard Stone, Moriko Ito, Louise Barys, Brandon Antonakos, Jing Yuan, Irene Simkin, Takaomi Sanda, Tao Ren, Atsushi Nonami, Vesselina G. Cooke, Ensar Halilovic, Ellen Weisberg
Supplementary Table III: AML patient samples tested with HDM2 inhibitor, CGM097: IC50 values for CGM097.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d9f78b11fd339b51f82e9097596b5f
https://doi.org/10.1158/1535-7163.22506781.v1
https://doi.org/10.1158/1535-7163.22506781.v1
Autor:
James D. Griffin, Marion Wiesmann, Sean M. McDonough, Jens U. Wuerthner, Sebastien Jeay, Martin Sattler, Erik Nelson, Kristen Cowens, Ilene Galinsky, Richard Stone, Moriko Ito, Louise Barys, Brandon Antonakos, Jing Yuan, Irene Simkin, Takaomi Sanda, Tao Ren, Atsushi Nonami, Vesselina G. Cooke, Ensar Halilovic, Ellen Weisberg
The tumor suppressor p53 is a key regulator of apoptosis and functions upstream in the apoptotic cascade by both indirectly and directly regulating Bcl-2 family proteins. In cells expressing wild-type (WT) p53, the HDM2 protein binds to p53 and block
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a202bb70fbbf98f1078a1bda4271a89
https://doi.org/10.1158/1535-7163.c.6538492.v1
https://doi.org/10.1158/1535-7163.c.6538492.v1
Autor:
James D. Griffin, Marion Wiesmann, Sean M. McDonough, Jens U. Wuerthner, Sebastien Jeay, Martin Sattler, Erik Nelson, Kristen Cowens, Ilene Galinsky, Richard Stone, Moriko Ito, Louise Barys, Brandon Antonakos, Jing Yuan, Irene Simkin, Takaomi Sanda, Tao Ren, Atsushi Nonami, Vesselina G. Cooke, Ensar Halilovic, Ellen Weisberg
Supplementary Figures 1-7 Supplementary Figure 1. Amplification and sequencing primers used for genotyping of p53 in AML patient samples. Supplementary Figure 2. Apoptosis data corresponding to representative bar graphs shown in Figure 1C. Supplement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c85fda8083880149c6582ea722cbd30
https://doi.org/10.1158/1535-7163.22506790
https://doi.org/10.1158/1535-7163.22506790
Autor:
Oluwatosin A Olayinka, Junming Hu, Nicholas K O'Neill, Melissa Wong, Hannah Rickner, Irene Simkin, Thor D. Stein, Benjamin Wolozin, Xiaoling Zhang, Lindsay A. Farrer
Publikováno v:
Alzheimer's & Dementia. 18
Autor:
Brandon E. Frank, Madeline Ally, Bailee Brekke, Henrik Zetterberg, Kaj Blennow, Michael Sugarman, Nicholas J. Ashton, Thomas K. Karikari, Yorghos Tripodis, Ann C. McKee, Thor D. Stein, Brett M. Martin, Joseph Palmisano, Eric Steinberg, Irene Simkin, Katherine W. Turk, Andrew Budson, Maureen K. O'Connor, Rhoda Au, Wendy Qiu, Lee E. Goldstein, Ronald J. Killiany, Neil W. Kowall, Jesse Mez, Robert A. Stern, Michael L. Alosco
Publikováno v:
Alzheimer's & Dementia. 17
Autor:
Robert S. Stern, Henrik Zetterberg, Jesse Mez, Joseph Palmisano, Maureen K. O’Connor, Ann C. McKee, Thor D. Stein, Eric G. Steinberg, Rhoda Au, Michael A. Sugarman, Lee E. Goldstein, Kaj Blennow, Yorghos Tripodis, Ronald J. Killiany, Neil W. Kowall, Michael L. Alosco, Andrew E. Budson, Brett Martin, Wendy Qiu, Irene Simkin
Publikováno v:
Neurobiol Aging
We examined baseline and longitudinal associations between plasma neurofilament light (NfL) and total tau (t-tau), and the clinical presentation of Alzheimer's disease (AD). A total of 579 participants (238, normal cognition [NC]; 185, mild cognitive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffbcf52e3223e8a82a7acc7f1878f118
https://europepmc.org/articles/PMC7484086/
https://europepmc.org/articles/PMC7484086/
Autor:
George J. Murphy, Hatem O. Qutub, P.K. Patra, Abdulrahman Alsultan, Hong-Yuan Luo, Shuai Wang, Zaki A. Naserullah, David H.K. Chui, Heather L. Edward, Heather Shappell, Vinod Vathipadiekal, Irene Simkin, Paola Sebastiani, Zhihua Jiang, Shengwen Huang, Fahad Al-Muhanna, Ahmed M. Al-Suliman, Gustavo Mostoslavsky, John J. Farrell, Lindsay A. Farrer, Abdullah M. Al-Rubaish, Martin H. Steinberg, Amein K. Al-Ali
Publikováno v:
American Journal of Hematology. 91:1118-1122
Fetal hemoglobin (HbF) levels are higher in the Arab-Indian (AI) β-globin gene haplotype of sickle cell anemia compared with African-origin haplotypes. To study genetic elements that effect HbF expression in the AI haplotype we completed whole genom
Autor:
Vesselina G. Cooke, Atsushi Nonami, Takaomi Sanda, Tao Ren, Sébastien Jeay, Irene Simkin, Ilene Galinsky, Sean McDonough, Ellen Weisberg, Erik Nelson, Jens Wuerthner, Richard Stone, Marion Wiesmann, James D. Griffin, Kristen Cowens, Jing Yuan, Louise Barys, Martin Sattler, Moriko Ito, Brandon Antonakos, Ensar Halilovic
Publikováno v:
Molecular Cancer Therapeutics. 14:2249-2259
The tumor suppressor p53 is a key regulator of apoptosis and functions upstream in the apoptotic cascade by both indirectly and directly regulating Bcl-2 family proteins. In cells expressing wild-type (WT) p53, the HDM2 protein binds to p53 and block