Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Irene Scarfo"'
Autor:
Patrick A. Baeuerle, Jian Ding, Ekta Patel, Niko Thorausch, Holly Horton, Jessica Gierut, Irene Scarfo, Rashmi Choudhary, Olga Kiner, Janani Krishnamurthy, Bonnie Le, Anna Morath, G. Christian Baldeviano, Justin Quinn, Patrick Tavares, Qi Wei, Solly Weiler, Marcela V. Maus, Daniel Getts, Wolfgang W. Schamel, Robert Hofmeister
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Supraphysiological T cell activation by chimeric antigen receptor (CAR) contributes to T cell exhaustion and adverse events in CAR T cell therapies. Here the authors engineer a synthetic antigen receptor that integrates into the endogenous TCR comple
Externí odkaz:
https://doaj.org/article/42c1e735be344a329bcc2474e5dbd81b
Autor:
Angela C. Boroughs, Irene Scarfo, Nickolas Attanasio, Thomas Gardner, Jenessa B. Smith, Jennifer McDevitt, Laura Lim, Nishant Mehta, Suchismita Mohanty, James Zhang, Eric Cui, Vibhavari Sail, Amanda Fearon, Samuel Williams, Stephen Santoro, W. Nicholas Haining, Levi Gray-Rupp
Publikováno v:
Cancer Research. 83:4088-4088
Clinically effective CAR-T cell therapy for solid tumors, such as clear cell renal cell carcinoma (ccRCC), will require substantial T cell engineering to increase their specificity and potency. We have developed an Integrated Circuit T cell (ICT) tha
Autor:
Ran Jing, Irene Scarfo, Mohamad Ali Najia, Edroaldo Lummertz da Rocha, Areum Han, Michael Sanborn, Trevor Bingham, Caroline Kubaczka, Deepak K. Jha, Marcelo Falchetti, Thorsten M. Schlaeger, Trista E. North, Marcela V. Maus, George Q. Daley
Publikováno v:
Cell Stem Cell. 29:1181-1196.e6
Human induced pluripotent stem cells (iPSCs) provide a potentially unlimited resource for cell therapies, but the derivation of mature cell types remains challenging. The histone methyltransferase EZH1 is a negative regulator of lymphoid potential du
Autor:
Rebecca Larson, Michael Kann, Stefanie Bailey, Nicholas Haradhvala, Kai Stewart, Amanda Bouffard, Irene Scarfo, Mark Leick, Trisha R Berger, Max Jan, Julia Joung, Tamara Ouspenskaia, Travis Law, Aviv Regev, Gad Getz, Marcela Maus
Publikováno v:
The Journal of Immunology. 208:176.18-176.18
Though CAR T cell therapy has had success treating hematologic malignancies, these treatments have shown only modest efficacy in solid tumors. Little is known about the necessary molecular components required for CAR T cell cytotoxicity, especially i
Autor:
Rebecca C. Larson, Michael C. Kann, Charlotte Graham, Christopher W. Mount, Ana P. Castano, Won-Ho Lee, Amanda A. Bouffard, Hana N. Takei, Antonio J. Almazan, Irene Scarfó, Trisha R. Berger, Andrea Schmidts, Matthew J. Frigault, Kathleen M. E. Gallagher, Marcela V. Maus
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Chimeric Antigen Receptor (CAR) T cells directed to B cell maturation antigen (BCMA) mediate profound responses in patients with multiple myeloma, but most patients do not achieve long-term complete remissions. In addition, recent evidence s
Externí odkaz:
https://doaj.org/article/008a498ec868469ca7437a0db7630ab9
Autor:
Ivan Chan, Laura Lim, Irene Scarfò, Darrian Moskowitz, Beatriz Millare, Kevin Dang, Jeremy Chen, Nickolas Attanasio, Angela Boroughs, Michelle Nguyen, Suchismita Mohanty, Jenessa Smith, James Zhang, Jennifer McDevitt, Thomas J Gardner, Alma Gomez, Vince Thomas, Marvin Chew, Rakesh Sudhakah, Amanda Fearon, Vibhavari Sail, Stanley Zhou
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/a27f077956a146d6ba279e1956215f55
Autor:
Irene Scarfò, Stephen Santoro, Aaron Cooper, Jun Feng, Dina Polyak, Michelle Nguyen, James Zhang, Hongruo Yun, Jasper Williams, Jessica Fuhriman, Jennifer McDevitt
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/8e6c0996f9bb47a1a706990875c81c33
Autor:
Rebecca Larson, Ana Castano, Amanda Bouffard, Irene Scarfo, Michael Kann, Andrea Schmidts, Kathleen Gallagher, Marcela Valderrama Maus
Publikováno v:
The Journal of Immunology. 204:246.3-246.3
One of the most promising candidates for Chimeric Antigen Receptor (CAR) T cell therapy beyond CAR19 is treatment of multiple myeloma with CAR T cells targeting B cell maturation antigen (BCMA). However, current reports of BCMA CAR in the clinic have
Autor:
Andrea Schmidts, Maria Ormhøj, Bryan D. Choi, Allison O. Taylor, Amanda A. Bouffard, Irene Scarfò, Rebecca C. Larson, Matthew J. Frigault, Kathleen Gallagher, Ana P. Castano, Lauren S. Riley, Maria L. Cabral, Angela C. Boroughs, Rubí M.-H. Velasco Cárdenas, Wolfgang Schamel, Jing Zhou, Sean Mackay, Yu-Tzu Tai, Kenneth C. Anderson, Marcela V. Maus
Publikováno v:
Blood Advances, Vol 3, Iss 21, Pp 3248-3260 (2019)
Abstract: Chimeric antigen receptor (CAR) T cells (CARTs) have shown tremendous potential for the treatment of certain B-cell malignancies, including patients with relapsed/refractory multiple myeloma (MM). Targeting the B-cell maturation antigen (BC
Externí odkaz:
https://doaj.org/article/744190eefb7f4eac95dde4520a55224b
Autor:
Bryan D. Choi, Xiaoling Yu, Ana P. Castano, Henia Darr, Daniel B. Henderson, Amanda A. Bouffard, Rebecca C. Larson, Irene Scarfò, Stefanie R. Bailey, Genevieve M. Gerhard, Matthew J. Frigault, Mark B. Leick, Andrea Schmidts, Jason G. Sagert, William T. Curry, Bob S. Carter, Marcela V. Maus
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-8 (2019)
Abstract Despite remarkable success in the treatment of hematological malignancies, CAR T-cell therapies for solid tumors have floundered, in large part due to local immune suppression and the effects of prolonged stimulation leading to T-cell dysfun
Externí odkaz:
https://doaj.org/article/987e2dc848b84c4ebabd4c5eacf43cbb