Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Irene Sargiannidou"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9588 (2024)
Even though several highly effective treatments have been developed for multiple sclerosis (MS), the underlying pathological mechanisms and drivers of the disease have not been fully elucidated. In recent years, there has been a growing interest in s
Externí odkaz:
https://doaj.org/article/e4f12844c16a44e78ae5c1920d672737
Autor:
Alexia Kagiava, Christos Karaiskos, George Lapathitis, Amanda Heslegrave, Irene Sargiannidou, Henrik Zetterberg, Assumpció Bosch, Kleopas A. Kleopa
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 377-393 (2023)
X-linked Charcot-Marie-Tooth disease type 1 (CMT1X) is a demyelinating neuropathy resulting from loss-of-function mutations affecting the GJB1/connexin 32 (Cx32) gene. We previously showed functional and morphological improvement in Gjb1-null mice fo
Externí odkaz:
https://doaj.org/article/d4f32062b79d47ecacc281e8ce18674a
Autor:
Kyriaki Savva, Margarita Zachariou, Demos Kynigopoulos, Eleni Fella, Maria-Ioanna Vitali, Xeni Kosofidou, Michail Spyrou, Irene Sargiannidou, Elena Panayiotou, Nikolas Dietis, George M. Spyrou
Publikováno v:
Life, Vol 13, Iss 5, p 1095 (2023)
Alzheimer’s disease (AD) is a progressive neurodegenerative disease and is the most common type of dementia. Although a considerably large amount of money has been invested in drug development for AD, no disease modifying treatment has been detecte
Externí odkaz:
https://doaj.org/article/dcbacf36dc954ed09385abfc3a44fe05
Autor:
Maria Pechlivanidou, Ioanna Kousiappa, Stella Angeli, Irene Sargiannidou, Andreas M. Koupparis, Savvas S. Papacostas, Kleopas A. Kleopa
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15597 (2022)
Gap junctions (GJs) are specialized transmembrane channels assembled by two hemi-channels of six connexin (Cx) proteins that facilitate neuroglial crosstalk in the central nervous system (CNS). Previous studies confirmed the crucial role of glial GJs
Externí odkaz:
https://doaj.org/article/cf5c1bbc2d094e2e84691252d25988b8
Autor:
Irene Sargiannidou, Violetta Christophidou-Anastasiadou, Andreas Hadjisavvas, George A. Tanteles, Kleopas A. Kleopa
Publikováno v:
Frontiers in Genetics, Vol 11 (2021)
Oculodentodigital dysplasia syndrome is associated with numerous pathogenic variants in GJA1, the gene encoding connexin43 gap junction protein. A novel in-frame deletion (p.Lys134del) was found in our clinic. The patient showed all the typical dysmo
Externí odkaz:
https://doaj.org/article/f8a93ec4d9a64685bfdeb67128dcfbb9
Autor:
Stella Angeli, Ioanna Kousiappa, Marios Stavrou, Irene Sargiannidou, Elena Georgiou, Savvas S. Papacostas, Kleopas A. Kleopa
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Glial gap junction proteins, called connexins (Cxs), form gap junctions in the central nervous system (CNS) to allow the bidirectional cytosolic exchange of molecules between adjacent cells. Their involvement in inheritable diseases and the use of ex
Externí odkaz:
https://doaj.org/article/bd395554dc5742b88542c350134101c6
Autor:
Filippos Stavropoulos, Irene Sargiannidou, Louiza Potamiti, Alexia Kagiava, Mihalis I. Panayiotidis, Ji Hyun Bae, Su Cheong Yeom, Jae Young Lee, Kleopas A. Kleopa
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11569 (2021)
Charcot-Marie-Tooth disease type 2A (CMT2A) is the most common hereditary axonal neuropathy caused by mutations in MFN2 encoding Mitofusin-2, a multifunctional protein located in the outer mitochondrial membrane. In order to study the effects of a no
Externí odkaz:
https://doaj.org/article/7a19fa7087544b0ab83ac09a7ccee5ab
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 6048 (2021)
Inherited neuropathies known as Charcot-Marie-Tooth (CMT) disease are genetically heterogeneous disorders affecting the peripheral nerves, causing significant and slowly progressive disability over the lifespan. The discovery of their diverse molecul
Externí odkaz:
https://doaj.org/article/9091fc4e5b68440284220316d033ad23
Publikováno v:
Pharmaceuticals, Vol 14, Iss 7, p 621 (2021)
Induction of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), in connexin 32 (Cx32) or Cx47 knockout (KO) mice with deficiency in oligodendrocyte gap junctions (GJs) results in a more severe disease course.
Externí odkaz:
https://doaj.org/article/a71ed17358b14981bd8996a003eaf243
Autor:
Irene Sargiannidou, Meejin Ahn, Alan D. Enriquez, Alejandro Peinado, Richard Reynolds, Charles Abrams, Steven S. Scherer, Kleopas A. Kleopa
Publikováno v:
Neurobiology of Disease, Vol 30, Iss 2, Pp 221-233 (2008)
Murine oligodendrocytes express the gap junction (GJ) proteins connexin32 (Cx32), Cx47, and Cx29. CNS phenotypes in patients with X-linked Charcot–Marie–Tooth disease may be caused by dominant effects of Cx32 mutations on other connexins. Here we
Externí odkaz:
https://doaj.org/article/3b57352e418d48b4a8de794a67e87cd4