Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Irene Santos-Barriopedro"'
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Proximity biotinylation is a powerful tool to profile interactomes, but it requires genetic engineering of the target protein. Here, the authors develop a proximity biotinylation enzyme that can be directed to the target using antibodies, enabling in
Externí odkaz:
https://doaj.org/article/daee1039e77c42bc92b128ce138c9f8d
Autor:
Sonali Bahl, Hongbo Ling, Nuwan P. N. Acharige, Irene Santos-Barriopedro, Mary Kay H. Pflum, Edward Seto
Publikováno v:
Cell Death and Disease, Vol 12, Iss 5, Pp 1-17 (2021)
Abstract HDAC1 is the prototypical human histone deacetylase (HDAC) enzyme responsible for catalyzing the removal of acetyl group from lysine residues on many substrate proteins. By deacetylating histones and non-histone proteins, HDAC1 has a profoun
Externí odkaz:
https://doaj.org/article/3bc10b248f614d199456b5bb1c309538
Autor:
Irene Santos-Barriopedro, Laia Bosch-Presegué, Anna Marazuela-Duque, Carolina de la Torre, Carlota Colomer, Berta N. Vazquez, Thomas Fuhrmann, Bárbara Martínez-Pastor, Wenfu Lu, Thomas Braun, Eva Bober, Thomas Jenuwein, Lourdes Serrano, Manel Esteller, Zhenbang Chen, Silvia Barceló-Batllori, Raúl Mostoslavsky, Lluis Espinosa, Alejandro Vaquero
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Sirtuins are involved in the regulation of responses to diverse types of cellular stress. Here the authors describe the SirT6-dependent cysteine monoubiquitination of the histone methyltransferase Suv39h1 as part of a regulatory circuit for the NF-κ
Externí odkaz:
https://doaj.org/article/5703e4bf0087489eaecd2013c1eb52d7
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 4 (2018)
The NF-κB pathway regulates cell physiology under stress conditions. We have recently described a novel NF-κB regulatory mechanism, by which SIRT6 induces cysteine monoubiquitination of the methyltransferase SUV39H1. This causes SUV39H1 dissociatio
Externí odkaz:
https://doaj.org/article/c34f2e2548d44e39a9e7507a0f95f3aa
Publikováno v:
Nature Protocols, 18, pp. 36-57
Nature Protocols, 18, 36-57
Nature Protocols, 18, 36-57
Proximity biotinylation is a commonly used method to identify the in vivo proximal proteome for proteins of interest. This technology typically relies on fusing a bait protein to a biotin ligase using overexpression or clustered regularly interspaced
There is a growing need in molecular biology to interrogate samples for higher number of biomarkers, beyond the 2 to 5 biomarkers typically addressable with standard PCR technologies. Here, we demonstrate a novel approach to increase the level of mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee99b3848c14bf6de06bc17948d5d649
https://doi.org/10.1101/2023.05.10.540190
https://doi.org/10.1101/2023.05.10.540190
Publikováno v:
Genes & Cancer. 10:119-133
Temozolomide (TMZ) is an alkylating agent chemotherapy drug used as a first-line treatment for glioblastoma multiforme (GBM). O6-methyl-guanine DNA methyltransferase (MGMT) repairs DNA damage induced by TMZ; hence, elevated MGMT levels usually correl
Autor:
Michael J. Edel, Carme Grau-Bove, Francisco Vidal Pérez, Manel Juan Otero, Raul Delgado-Morales, Maria A. Blasco, Carlos Hobeich Naya, Agueda M. Tejera, Alejandro Vaquero, C. Barrot, Irene Santos-Barriopedro, Iris Garcia-Martínez, Ana Belén Alvarez-Palomo, Manel Esteller, Jovita Mezquita-Pla, Sebastian Moran, Victoria Moreno-Manzano, Jordi Requena-Osete
Publikováno v:
STEM CELLS
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
instname
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
instname
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
A key challenge for clinical application of induced pluripotent stem cells (iPSC) to accurately model and treat human pathologies depends on developing a method to generate genetically stable cells to reduce long-term risks of cell transplant therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b21653ddfbbf30e81baf22d70748f4
https://fundanet.cipf.es/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3661
https://fundanet.cipf.es/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3661
Autor:
Nuwan P. N. Acharige, Mary Kay H. Pflum, Hongbo Ling, Edward Seto, Irene Santos-Barriopedro, Sonali Bahl
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 5, Pp 1-17 (2021)
Cell Death and Disease, Vol 12, Iss 5, Pp 1-17 (2021)
HDAC1 is the prototypical human histone deacetylase (HDAC) enzyme responsible for catalyzing the removal of acetyl group from lysine residues on many substrate proteins. By deacetylating histones and non-histone proteins, HDAC1 has a profound effect
Publikováno v:
Genes & Cancer
Temozolomide (TMZ) is an alkylating agent chemotherapy drug used as a first-line treatment for glioblastoma multiforme (GBM). O6-methyl-guanine DNA methyltransferase (MGMT) repairs DNA damage induced by TMZ; hence, elevated MGMT levels usually correl