Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Irene Sánchez-Morán"'
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S137- (2023)
Externí odkaz:
https://doaj.org/article/b598b63a5e3e4622aa4c3067311b50ea
Publikováno v:
Iubmb Life
Stroke is a major cause of death and long-term disability in the adult. Neuronal apoptosis plays an essential role in the pathophysiology of ischemic brain damage and impaired functional recovery after stroke. The tumor suppressor protein p53 regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::925be01999f963fb0c7ab79cf0773249
http://europepmc.org/articles/PMC8248069
http://europepmc.org/articles/PMC8248069
Autor:
Rebeca Vecino, Emilia Barrio, Maria Delgado-Esteban, Alberto Suarez-Pindado, Irene Sánchez-Morán, Juan P. Bolaños, Cristina Méndez Rodríguez, Angeles Almeida
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 14
Digital.CSIC. Repositorio Institucional del CSIC
instname
International Journal of Molecular Sciences, Vol 22, Iss 7275, p 7275 (2021)
Volume 22
Issue 14
Digital.CSIC. Repositorio Institucional del CSIC
instname
International Journal of Molecular Sciences, Vol 22, Iss 7275, p 7275 (2021)
One of the most important mechanisms of preconditioning-mediated neuroprotection is the attenuation of cell apoptosis, inducing brain tolerance after a subsequent injurious ischemia. In this context, the antiapoptotic PI3K/AKT signaling pathway plays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::649f7aa6800577c4e42256a3e5ce0787
http://europepmc.org/articles/PMC8304232
http://europepmc.org/articles/PMC8304232
Trabajo presentado en la 20th Biennial Meeting of The Society for Free Radical Research International (SFRR-I) celebrada online del 15 al 18 de marzo de 2021
Ischemic stroke is the leading cause of neurologic death and long-term adult disability
Ischemic stroke is the leading cause of neurologic death and long-term adult disability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed548f713ca7cabc67dd0c4675d53991
http://hdl.handle.net/10261/310222
http://hdl.handle.net/10261/310222
Autor:
Rebeca Lapresa, José Castillo, Tomás Sobrino, Juan P. Bolaños, Cristina Rodríguez, Jesús Agulla, Angeles Almeida, Irene Sánchez-Morán
Publikováno v:
Science Advances
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
Failure of neurons to efficiently repair DNA double-strand breaks (DSBs) contributes to cerebral damage after stroke. However, the molecular machinery that regulates DNA repair in this neurological disorder is unknown. Here, we found that DSBs in oxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d051bb70a09c08d0571763895763cead
http://europepmc.org/articles/PMC7541066
http://europepmc.org/articles/PMC7541066
Autor:
Irene Sánchez-Morán, Marta Domínguez-Martínez, José Castillo, José C. Gómez-Sánchez, Cristina Rodríguez, María E. Ramos-Araque, Juan P. Bolaños, Angeles Almeida, Jesús Agulla, Maria Delgado-Esteban, Tomás Sobrino
Publikováno v:
Stroke
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
[Background and Purpose] The E3 ubiquitin ligase MDM2 (murine double minute 2) is the main negative regulator of the p53 protein—a key player in neuronal apoptosis after ischemia. A functional single-nucleotide polymorphism in the human MDM2 gene p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::354d761d69aa92339e88055d71976c2d
https://doi.org/10.1161/strokeaha.118.022529
https://doi.org/10.1161/strokeaha.118.022529
Autor:
Juan P. Bolaños, Rubén Zamarreño, Estefanía Prieto, Irene Sánchez-Morán, Rebeca Lapresa, Jesús Agulla, Angeles Almeida
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Neurodegeneration in selective brain areas underlies the pathology of Alzheimer's disease (AD). Although oligomeric amyloid-β (Aβ) plays a central role in the AD pathogenesis, the mechanism of neuronal loss in response to Aβ remains elusive. The p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6000352947828e0922dd337f5d5901
https://pubmed.ncbi.nlm.nih.gov/30452955
https://pubmed.ncbi.nlm.nih.gov/30452955
The p53 tumor suppressor protein, a key regulator of cell apoptosis, has been described to accumulate in affected brain areas from Alzheimer’s disease (AD) patients. However, whether p53 plays any role in AD pathogenesis remains unknown. Here, we f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a888c7fb941c13b2a1ae5c7bab99224
https://doi.org/10.1101/365437
https://doi.org/10.1101/365437
Autor:
Irene Sánchez Morán
Publikováno v:
GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname
instname
El ictus es una enfermedad cerebrovascular heterogenea con multitud de factores que determinan el riesgo, gravedad y pronostico de la misma. La recuperacion de la funcion neurologica tras un ictus viene determinada por el balance entre dano y reparac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc2879e18ee31d0ec18ed653b46844d
https://doi.org/10.14201/gredos.137368
https://doi.org/10.14201/gredos.137368
Autor:
Verónica, Bobo-Jiménez, María, Delgado-Esteban, Julie, Angibaud, Irene, Sánchez-Morán, Antonio, de la Fuente, Javier, Yajeya, U Valentin, Nägerl, José, Castillo, Juan P, Bolaños, Angeles, Almeida
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(17)
Disruption of neuronal dendrites causes cognitive impairment in Alzheimer’s disease (AD). Rock2, a kinase of the Rho family of proteins, is a dendrite destabilizer that accumulates in the AD brain. However, why Rock2 aberrantly aggregates, causing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f9173a70a118c3f0f7be4d2e5542b9fd
https://pubmed.ncbi.nlm.nih.gov/28396402
https://pubmed.ncbi.nlm.nih.gov/28396402