Update to the study protocol, including statistical analysis plan, for the multicentre, randomised controlled OuTSMART trial: a combined screening/treatment programme to prevent premature failure of renal transplants due to chronic rejection in patients with HLA antibodies

Autor: Dominic Stringer, Leanne M. Gardner, Janet L. Peacock, Irene Rebollo-Mesa, Rachel Hilton, Olivia Shaw, Richard Baker, Brendan Clark, Raj C. Thuraisingham, Matthew Buckland, Michael Picton, Judith Worthington, Richard Borrows, David Briggs, Sapna Shah, Kin Yee Shiu, Keith McCullough, Mysore Phanish, Janet Hegarty, John Stoves, Aimun Ahmed, Waqar Ayub, Robert Horne, Paul McCrone, Joanna Kelly, Caroline Murphy, Anthony Dorling

Publikováno v: Trials, Vol 20, Iss 1, Pp 1-9 (2019)

Abstract Background Chronic rejection is the single biggest cause of premature kidney graft failure. HLA antibodies (Ab) are an established prognostic biomarker for premature graft failure so there is a need to test whether treatment decisions based

Externí odkaz: https://doaj.org/article/08a2f39e81b34e6a91eb89c65444c54f

Development and validation of the first consensus gene-expression signature of operational tolerance in kidney transplantation, incorporating adjustment for immunosuppressive drug therapy

Autor: Sofia Christakoudi, Manohursingh Runglall, Paula Mobillo, Irene Rebollo-Mesa, Tjir-Li Tsui, Estefania Nova-Lamperti, Catharine Taube, Sonia Norris, Yogesh Kamra, Rachel Hilton, Titus Augustine, Sunil Bhandari, Richard Baker, David Berglund, Sue Carr, David Game, Sian Griffin, Philip A. Kalra, Robert Lewis, Patrick B. Mark, Stephen D. Marks, Iain MacPhee, William McKane, Markus G. Mohaupt, Estela Paz-Artal, Sui Phin Kon, Daniel Serón, Manish D. Sinha, Beatriz Tucker, Ondrej Viklický, Daniel Stahl, Robert I. Lechler, Graham M. Lord, Maria P. Hernandez-Fuentes

Publikováno v: EBioMedicine, Vol 58, Iss , Pp 102899- (2020)

Background: Kidney transplant recipients (KTRs) with “operational tolerance” (OT) maintain a functioning graft without immunosuppressive (IS) drugs, thus avoiding treatment complications. Nevertheless, IS drugs can influence gene-expression signa

Externí odkaz: https://doaj.org/article/3e888ca856124c02877325b343eab615

Erratum to: Methods for evaluating medical tests and biomarkers

Autor: Gowri Gopalakrishna, Miranda Langendam, Rob Scholten, Patrick Bossuyt, Mariska Leeflang, Anna Noel-Storr, James Thomas, Iain Marshall, Byron Wallace, Penny Whiting, Clare Davenport, Gowri GopalaKrishna, Isabel de Salis, Sue Mallett, Robert Wolff, Richard Riley, Marie Westwood, Jos Kleinen, Gary Collins, Hans Reitsma, Karel Moons, Antonia Zapf, Annika Hoyer, Katharina Kramer, Oliver Kuss, J. Ensor, J. J. Deeks, E. C. Martin, R. D. Riley, Gerta Rücker, Susanne Steinhauser, Martin Schumacher, Joie Ensor, Kym Snell, Brian Willis, Thomas Debray, Jon Deeks, Lavinia Ferrante di Ruffano, Sian Taylor-Phillips, Chris Hyde, Stuart A. Taylor, Gauraang Batnagar, STREAMLINE COLON Investigators, STREAMLINE LUNG Investigators, METRIC Investigators, Lavinia Ferrante Di Ruffano, Farah Seedat, Aileen Clarke, Sarah Byron, Frances Nixon, Rebecca Albrow, Thomas Walker, Carla Deakin, Zhivko Zhelev, Harriet Hunt, Yaling Yang, Lucy Abel, James Buchanan, Thomas Fanshawe, Bethany Shinkins, Laure Wynants, Jan Verbakel, Sabine Van Huffel, Dirk Timmerman, Ben Van Calster, Aeliko Zwinderman, Jason Oke, Jack O’Sullivan, Rafael Perera, Brian Nicholson, Hannah L. Bromley, Tracy E. Roberts, Adele Francis, Denniis Petrie, G. Bruce Mann, Kinga Malottki, Holly Smith, Lucinda Billingham, Alice Sitch, Oke Gerke, Mie Holm-Vilstrup, Eivind Antonsen Segtnan, Ulrich Halekoh, Poul Flemming Høilund-Carlsen, Bernard G. Francq, Jac Dinnes, Julie Parkes, Walter Gregory, Jenny Hewison, Doug Altman, William Rosenberg, Peter Selby, Julien Asselineau, Paul Perez, Aïssatou Paye, Emilie Bessede, Cécile Proust-Lima, Christiana Naaktgeboren, Joris de Groot, Anne Rutjes, Johannes Reitsma, Emmanuel Ogundimu, Jonathan Cook, Yannick Le Manach, Yvonne Vergouwe, Romin Pajouheshnia, Rolf Groenwold, Karen Moons, Linda Peelen, Daan Nieboer, Bavo De Cock, Micael J. Pencina, Ewout W. Steyerberg, Jennifer Cooper, Nick Parsons, Chris Stinton, Steve Smith, Andy Dickens, Rachel Jordan, Alexandra Enocson, David Fitzmaurice, Peymane Adab, Charles Boachie, Gaj Vidmar, Karoline Freeman, Martin Connock, Rachel Court, Carl Moons, Jessica Harris, Andrew Mumford, Zoe Plummer, Kurtis Lee, Barnaby Reeves, Chris Rogers, Veerle Verheyden, Gianni D. Angelini, Gavin J. Murphy, Jeremy Huddy, Melody Ni, Katherine Good, Graham Cooke, George Hanna, Jie Ma, K. G. M. (Carl) Moons, Joris A. H. de Groot, Doug G. Altman, Johannes B. Reitsma, Gary S. Collins, Karel G. M. Moons, Douglas G. Altman, Adina Najwa Kamarudin, Ruwanthi Kolamunnage-Dona, Trevor Cox, Simone Borsci, Teresa Pérez, M.Carmen Pardo, Angel Candela-Toha, Alfonso Muriel, Javier Zamora, Sabina Sanghera, Syed Mohiuddin, Richard Martin, Jenny Donovan, Joanna Coast, Mikyung Kelly Seo, John Cairns, Elizabeth Mitchell, Alison Smith, Judy Wright, Peter Hall, Michael Messenger, Nicola Calder, Nyantara Wickramasekera, Karen Vinall-Collier, Andrew Lewington, Johanna Damen, David Cairns, Michelle Hutchinson, Cathie Sturgeon, Liz Mitchel, Rebecca Kift, Sofia Christakoudi, Manohursingh Rungall, Paula Mobillo, Rosa Montero, Tjir-Li Tsui, Sui Phin Kon, Beatriz Tucker, Steven Sacks, Chris Farmer, Terry Strom, Paramit Chowdhury, Irene Rebollo-Mesa, Maria Hernandez-Fuentes, Johanna A. A. G. Damen, Thomas P. A. Debray, Pauline Heus, Lotty Hooft, Rob J. P. M. Scholten, Ewoud Schuit, Ioanna Tzoulaki, Camille M. Lassale, George C. M. Siontis, Virginia Chiocchia, Corran Roberts, Michael Maia Schlüssel, Stephen Gerry, James A. Black, Yvonne T. van der Schouw, Linda M. Peelen, Graeme Spence, David McCartney, Ann van den Bruel, Daniel Lasserson, Gail Hayward, Werner Vach, Antoinette de Jong, Coreline Burggraaff, Otto Hoekstra, Josée Zijlstra, Henrica de Vet, Sara Graziadio, Joy Allen, Louise Johnston, Rachel O’Leary, Michael Power, Louise Johnson, Ray Waters, John Simpson, Thomas R. Fanshawe, Peter Phillips, Andrew Plumb, Emma Helbren, Steve Halligan, Alastair Gale, Peggy Sekula, Willi Sauerbrei, Julia R. Forman, Susan J. Dutton, Yemisi Takwoingi, Elizabeth M. Hensor, Thomas E. Nichols, Emmanuelle Kempf, Raphael Porcher, Jennifer de Beyer, Douglas Altman, Sally Hopewell, John Dennis, Beverley Shields, Angus Jones, William Henley, Ewan Pearson, Andrew Hattersley, on behalf of the MASTERMIND consortium, Fueloep Scheibler, Anne Rummer, Sibylle Sturtz, Robert Großelfinger, Katie Banister, Craig Ramsay, Augusto Azuara-Blanco, Jennifer Burr, Manjula Kumarasamy, Rupert Bourne, Ijeoma Uchegbu, Jennifer Murphy, Alex Carter, Jen Murphy, Joachim Marti, Julie Eatock, Julie Robotham, Maria Dudareva, Mark Gilchrist, Alison Holmes, Phillip Monaghan, Sarah Lord, Andrew StJohn, Sverre Sandberg, Christa Cobbaert, Lieselotte Lennartz, Wilma Verhagen-Kamerbeek, Christoph Ebert, Andrea Horvath, for the Test Evaluation Working Group of the European Federation of Clinical Chemistry and Laboratory Medicine, Kevin Jenniskens, Jaime Peters, Bogdan Grigore, Obi Ukoumunne, Brooke Levis, Andrea Benedetti, Alexander W. Levis, John P. A. Ioannidis, Ian Shrier, Pim Cuijpers, Simon Gilbody, Lorie A. Kloda, Dean McMillan, Scott B Patten, Russell J. Steele, Roy C Ziegelstein, Charles H. Bombardier, Flavia de Lima Osório, Jesse R. Fann, Dwenda Gjerdingen, Femke Lamers, Manote Lotrakul, Sonia R Loureiro, Bernd Löwe, Juwita Shaaban, Lesley Stafford, Henk C. P. M. van Weert, Mary A. Whooley, Linda S. Williams, Karin A. Wittkampf, Albert S. Yeung, Brett D. Thombs, Chris Cooper, Tom Nieto, Claire Smith, Olga Tucker, Janine Dretzke, Andrew Beggs, Nirmala Rai, Sue Bayliss, Simon Stevens, Sue Mallet, Sudha Sundar, Emma Hall, Nuria Porta, David Lorente Estelles, Johann de Bono, on behalf of the CTC-STOP protocol development group

Publikováno v: Diagnostic and Prognostic Research, Vol 1, Iss 1, Pp 1-5 (2017)

Externí odkaz: https://doaj.org/article/6e4d4aeef31d4a4ab5f1974912d6fe8c

Ex vivo delivery of Mirococept: A dose-finding study in pig kidney after showing a low dose is insufficient to reduce delayed graft function in human kidney

Autor: Jonathon Olsburgh, Abdel Douiri, Guilherme Danzi, Anass Qasem, Richard A. G. Smith, Theodoros Kassimatis, Clare Flach, Peter J. Friend, Flavia Neri, Steven H. Sacks, James P. Hunter, Laura L. Nichols, Catherine Horsfield, Roseanna Greenlaw, Martin Drage, Irene Rebollo-Mesa, Julieta Karegli

Publikováno v: American Journal of Transplantation. 21:1012-1026

The complement system plays a pivotal role in the pathogenesis of ischemia-reperfusion injury in solid organ transplantation. Mirococept is a potent membrane-localizing complement inhibitor that can be administered ex vivo to the donor kidney prior t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0e402a35a421659f29b3e00ca62f50
https://doi.org/10.1111/ajt.16265

A multicenter randomized controlled trial indicates that paclitaxel-coated balloons provide no benefit for arteriovenous fistulas

Autor: Rebecca J Suckling, Leanne M. Gardner, Yanzhong Wang, Kate Steiner, Narayan Karunanithy, Simon Coles, Shoaib Shaikh, Farhan Ahmad, Irene Rebollo Mesa, Graeme Weir, Douglas Turner, Emily J. Robinson, Ashar Wadoodi, Laszlo Szabo, Sarah Lawman, James O. Simpson, Michael G. Robson, Anthony Dorling, C. Jason Wilkins, Colin Forman, Raymond Ramnarine, Rhys Lewlellyn, Neelanjan Das, Francis Calder, Janet L. Peacock, Ounali Jaffer, Raghuram Lakshminarayan, James O. Burton

Publikováno v: Karunanithy, N, Robinson, E J, Ahmad, F, Burton, J O, Calder, F, Coles, S, Das, N, Dorling, A, Forman, C, Jaffer, O, Lawman, S, Lakshminarayan, R, Lewlellyn, R, Peacock, J L, Ramnarine, R, Mesa, I R, Shaikh, S, Simpson, J, Steiner, K, Suckling, R, Szabo, L, Turner, D, Wadoodi, A, Wang, Y, Weir, G, Wilkins, C J, Gardner, L M & Robson, M G 2021, ' A multicenter randomized controlled trial indicates that paclitaxel-coated balloons provide no benefit for arteriovenous fistulas ', Kidney International, vol. 100, no. 2, pp. 447-456 . https://doi.org/10.1016/j.kint.2021.02.040

The role of paclitaxel-coated balloons has been established in the coronary and peripheral arterial circulations with recent interest in the use of paclitaxel-coated balloons to improve patency rates following angioplasty of arteriovenous fistulas. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c0d640cb0b12a7dee58db07b2f023d
https://kclpure.kcl.ac.uk/ws/files/148083947/PUREversion.pdf