Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Irene Polsky"'
Autor:
Tara Mirzadegan, Frank Diehl, Bettina Ebi, Sunil Bhakta, Irene Polsky, Deborah McCarley, Mary Mulkins, Gabe S. Weatherhead, Jean-Marc Lapierre, John Dankwardt, David Morgans, Robert Wilhelm, Kurt Jarnagin
Publikováno v:
Journal of Biological Chemistry. 275:25562-25571
Monocyte chemoattracant-1 (MCP-1) stimulates leukocyte chemotaxis to inflammatory sites, such as rheumatoid arthritis, atherosclerosis, and asthma, by use of the MCP-1 receptor, CCR2, a member of the G-protein-coupled seven-transmembrane receptor sup
Autor:
Sunil Bhakta, Kurt Jarnagin, Alan Kosaka, Tracy M. Handel, Chad D. Paavola, Adam Bloom, Dorit Grunberger, Frank Diehl, Stefan Hemmerich, Irene Polsky, Ann Ping-Tsou,‡,⊥, Richard Freedman, Debbie McCarley, Belinda Wong, Mary Mulkins
Publikováno v:
Biochemistry. 38:16167-16177
The CC chemokine, monocyte chemotactic protein, 1 (MCP-1) functions as a major chemoattractant for T-cells and monocytes by interacting with the seven-transmembrane G protein-coupled receptor CCR2. To identify which residues of MCP-1 contribute to si
Autor:
Mary Mulkins, Kelly Thompson, Joe H. B. Pease, Laura S. Mizoue, Tracy M. Handel, Tara Mirzadegan, Kurt Jarnagin, John L. Krstenansky, Stefan Hemmerich, Irene Polsky, Debbie McCarley, Chad D. Paavola, Dorit Grunberger, Sunil Bhakta, Richard Freedman, Belinda Wong, Adam Bloom, Simon Ming-Yuen Lee
Publikováno v:
Biochemistry. 38:13013-13025
The CC chemokine, MCP-1, has been identified as a major chemoattractant for T cells and monocytes, and plays a significant role in the pathology of inflammatory diseases. To identify the regions of MCP-1 that contact its receptor, CCR2, we substitute
Autor:
Stefan Hemmerich, Richard E. Bruehl, Brian Nicholas Cook, Irene Polsky, Wei-Ming Kao, Kendra G. Bowman, Carolyn R. Bertozzi, Alexander Bartes, Steven D. Rosen, Sunil Bhakta, Jin Kyu Lee
Publikováno v:
The Journal of biological chemistry. 275(51)
Based on sequence homology with a previously cloned human GlcNAc 6-O-sulfotransferase, we have identified an open reading frame (ORF) encoding a novel member of the Gal/GalNAc/GlcNAc 6-O-sulfotransferase (GST) family termed GST-5 on the human X chrom
Autor:
Mary Mulkins, Stefan Hemmerich, Kurt Jarnagin, Richard Freedman, Belinda Wong, Tracy M. Handel, Sunhil Bhakta, Ludwig Wiesent, Chad D. Paavola, Dorit Grunberger, Irene Polsky, Adam Bloom, Debbie McCarley
Publikováno v:
The Journal of biological chemistry. 273(50)
To address the role of dimerization in the function of the monocyte chemoattractant protein-1, MCP-1, we mutated residues that comprise the core of the dimerization interface and characterized the ability of these mutants to dimerize and to bind and