Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Irene Palomares-Pérez"'
Increased exosome secretion in neurons aging in vitro by NPC1-mediated endosomal cholesterol buildup
Autor:
Héctor Peinado, Verónica Miguel, Francesc X. Guix, Santiago Lamas, Mauricio G. Martin, Álvaro Casadomé-Perales, Inés López del Castillo, Ana Marrero Capitán, Irene Palomares-Pérez, Carlos G. Dotti, Leigh Goedeke, Carlos Fernández-Hernando
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Life Science Alliance
instname
Life Science Alliance
The present study unveils the molecular mechanism through which neurons in vitro compensate age-associated proteostasis defects by increasing exosome release.
As neurons age, they show a decrease in their ability to degrade proteins and membrane
As neurons age, they show a decrease in their ability to degrade proteins and membrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3014b737fe8ca097899f6a0a36e42cb0
http://hdl.handle.net/10261/266154
http://hdl.handle.net/10261/266154
Autor:
Takashi Saito, Jonathan E. Draffin, Francesc X. Guix, Lucía Chávez-Gutiérrez, Takaomi C. Saido, Ana Frank-García, Miguel Medina, Carlos G. Dotti, Maria Szaruga, Irene Palomares-Pérez, Silvia de Vidania, Miguel Calero
Publikováno v:
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
Repisalud
Instituto de Salud Carlos III (ISCIII)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Biblos-e Archivo. Repositorio Institucional de la UAM
Consejo Superior de Investigaciones Científicas (CSIC)
Frontiers in Neuroscience, Vol 14 (2020)
Frontiers in Neuroscience
Universidad Autónoma de Madrid
Repisalud
Instituto de Salud Carlos III (ISCIII)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Biblos-e Archivo. Repositorio Institucional de la UAM
Consejo Superior de Investigaciones Científicas (CSIC)
Frontiers in Neuroscience, Vol 14 (2020)
Frontiers in Neuroscience
In humans, a considerable number of the autopsy samples of cognitively normal individuals aged between 57 and 102 years have revealed the presence of amyloid plaques, one of the typical signs of AD, indicating that many of us use mechanisms that defe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b71386b8d9dde4ea1cc33ff56d8680
http://hdl.handle.net/10486/695839
http://hdl.handle.net/10486/695839
Autor:
Cristina Infantes-Rodríguez, Laura De Matteis, Jesús M. de la Fuente, María Alleva, Irene Palomares-Pérez, Takashi Saito, Álvaro Casadomé-Perales, José A. Esteban, Takaomi C. Saido, Carlos G. Dotti, Angel R. Nebreda
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
[Aim]: To determine whether a p38 MAPK inhibitor incorporated into nanoemulsion-based chitosan nanocapsules can reduce the activity of this kinase in the brain through their nasal administration in mice.
[Materials & methods]: We selected the p3
[Materials & methods]: We selected the p3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de870a12c8c7b4b7d91795518072bec2
http://hdl.handle.net/10261/208099
http://hdl.handle.net/10261/208099
Autor:
Sebastian Munck, Álvaro Casadomé-Perales, Detlef Balschun, Irene Palomares-Pérez, Ernest Palomer, Tariq Ahmed, Adrián Martín-Segura, Axelle Kerstens, Carlos G. Dotti
Publikováno v:
Aging Cell
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
In the brain, insulin plays an important role in cognitive processes. During aging, these faculties decline, as does insulin signaling. The mechanism behind this last phenomenon is unclear. In recent studies, we reported that the mild and gradual los
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b581bee3437637aa4e772859b99ab7f8
https://pubmed.ncbi.nlm.nih.gov/30884121
https://pubmed.ncbi.nlm.nih.gov/30884121
Autor:
Silvia de Vidania, Irene Palomares-Perez, Ana Frank-García, Takashi Saito, Takaomi C. Saido, Jonathan Draffin, María Szaruga, Lucía Chávez-Gutierrez, Miguel Calero, Miguel Medina, Francesc X. Guix, Carlos G. Dotti
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
In humans, a considerable number of the autopsy samples of cognitively normal individuals aged between 57 and 102 years have revealed the presence of amyloid plaques, one of the typical signs of AD, indicating that many of us use mechanisms that defe
Externí odkaz:
https://doaj.org/article/b8f75df402f046f794db3d97e1ac37b1