Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Irene Morganstern"'
Publikováno v:
International Journal of Endocrinology, Vol 2013 (2013)
Transcribed within the lateral hypothalamus, the neuropeptides orexin/hypocretin (OX) and melanin-concentrating hormone (MCH) both promote palatable food intake and are stimulated by palatable food. While these two neuropeptides share this similar po
Externí odkaz:
https://doaj.org/article/db984e15c48543b896ac7cbf4542fab1
Computational Analysis of Multidimensional Behavioral Alterations After Chronic Social Defeat Stress
Autor:
Irene Morganstern, Zachary S. Lorsch, Alberto Ambesi-Impiombato, Emer Leahy, Taleen Hanania, Rebecca Zenowich, Mukesh Bansal, Eric J. Nestler
Publikováno v:
Biological psychiatry. 89(9)
Background The study of depression in humans depends on animal models that attempt to mimic specific features of the human syndrome. Most studies focus on one or a few behavioral domains, with time and practical considerations prohibiting a comprehen
Publikováno v:
Brain research. 1741
Melanin-concentrating hormone (MCH) is a neuropeptide primarily transcribed in the lateral hypothalamus (LH), with vast projections to many areas throughout the central nervous system that play an important role in motivated behaviors and drug use. A
Autor:
Q. Kevin Fang, John Emmerson Campbell, Una Campbell, Philip Jones, Noel Aaron Powell, Vadim Alexandrov, Emily Sabath, Liming Shao, Kerry L. Spear, Irene Morganstern, Thomas H. Large, Taleen Hanania, Hua M. Zhong
Publikováno v:
MedChemComm. 7:1093-1101
Phenotypic drug discovery (PDD) is increasingly being recognized as a viable compliment to target-based drug discovery (TDD). By measuring functional changes, typically at a systems level, PDD can facilitate the identification of compounds having a d
Autor:
Jane Shaji, Sarah F. Leibowitz, Olga Karatayev, Sang-Ho Moon, Irene Morganstern, Olga Lukatskaya, Wei-Ran Guo
Publikováno v:
Psychopharmacology. 230:509-524
While clinical studies show maternal consumption of palatable fat-rich diets during pregnancy to negatively impact the children's behaviors and increase their vulnerability to drug abuse, the precise behavioral and neurochemical mechanisms mediating
Publikováno v:
Alcohol. 46:559-568
The process of ethanol anticipation is a particularly important phenomenon that can determine subsequent drug-taking behavior. Recent studies suggest that systems within the medial prefrontal cortex (mPFC), during anticipation, may contribute to the
Publikováno v:
Brain Research. 1470:24-34
Clinical reports suggest a positive association between fat consumption and the incidence of hyperactivity, impulsivity and cognitive abnormalities. To investigate possible mechanisms underlying these disturbances under short-term conditions, we exam
Publikováno v:
ILAR Journal. 53:35-58
Consummatory behavior is driven not just by caloric need but also by emotional need. In the last several decades, a wide variety of models have been used to study the systems that drive food and drug intake. These include selective breeding for a spe
Publikováno v:
Neuroscience. 193:10-20
Recent studies show that the non-opioid peptides, galanin (GAL) and orexin (OX), are similar to the opioid enkephalin (ENK) in being stimulated by dietary fat and also in enhancing the consumption of a high-fat diet (HFD). This suggests that, when an
Publikováno v:
Physiology & Behavior. 104:128-137
Historically, studies of food intake regulation started with the hypothalamus and gradually expanded to mesocorticolimbic regions, while studies of drug use began with mesocorticolimbic regions and now include the hypothalamus. As research on ingesti