MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity

Autor: Irene Moretti, Stefano Ciciliot, Kenneth A. Dyar, Reimar Abraham, Marta Murgia, Lisa Agatea, Takayuki Akimoto, Silvio Bicciato, Mattia Forcato, Philippe Pierre, N. Henriette Uhlenhaut, Peter W. J. Rigby, Jaime J. Carvajal, Bert Blaauw, Elisa Calabria, Stefano Schiaffino

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)

Mrf4 is a transcription factor important for muscle development, but despite high expression its function in adults is unknown. Here the authors show that interfering with Mrf4 in adult mice leads to muscle hypertrophy by activating MEF2-dependent tr

Externí odkaz: https://doaj.org/article/9baf8edc4e774e3bbf5c7edc3c424c25

Kin Enough

Autor: Irene Moretti

Publikováno v: Social Analysis: The International Journal of Anthropology, 65(4), 90-110
Social Analysis

The moral imperatives of kinship in Italy today articulate state law and market in measurements of closeness for access to resources and care. The negotiations of insurance payouts for road crash victims offer a privileged vantage point to study this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc1fa8afa1435b2b53be0e6d1553d097
https://doi.org/10.3167/sa.2021.650405

MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity

Autor: Takayuki Akimoto, N. Henriette Uhlenhaut, Philippe Pierre, Elisa Calabria, Reimar Abraham, Stefano Ciciliot, Lisa Agatea, Peter W. J. Rigby, Silvio Bicciato, Marta Murgia, Mattia Forcato, Stefano Schiaffino, Kenneth A. Dyar, Jaime J. Carvajal, Irene Moretti, Bert Blaauw

Publikováno v: Europe PubMed Central
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Nature Communications, Nature Publishing Group, 2016, 7, ⟨10.1038/ncomms12397⟩
Nat. Commun. 7:12397 (2016)
Nature Communications, 2016, 7, ⟨10.1038/ncomms12397⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname

et al.
The myogenic regulatory factor MRF4 is highly expressed in adult skeletal muscle but its function is unknown. Here we show that Mrf4 knockdown in adult muscle induces hypertrophy and prevents denervation-induced atrophy. This effect is ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf7badb3f2578d4f641a3404c134487
http://hdl.handle.net/11577/3195569

Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock

Autor: Mattia Albiero, Vishal R. Patel, Bert Blaauw, Lauren E. Wright, Rasmus S. Biensø, Pierre Baldi, Mattia Forcato, Kristin Eckel-Mahan, Anders Gudiksen, Silvio Bicciato, Guidantonio Malagoli Tagliazucchi, Francesca Solagna, Paolo Sassone-Corsi, Marcia Ivonne Peña Paz, Henriette Pilegaard, Rosario Rizzuto, Stefano Ciciliot, Kenneth A. Dyar, Irene Moretti, Stefano Schiaffino

Publikováno v: Molecular metabolism, vol 3, iss 1
Dyar, K A, Ciciliot, S, Wright, L E, Biensø, R S, Tagliazucchi, G M, Patel, V R, Forcato, M, Paz, M I P, Gudiksen, A, Solagna, F, Albiero, M, Moretti, I, Eckel-Mahan, K L, Baldi, P, Sassone-Corsi, P, Rizzuto, R, Bicciato, S, Pilegaard, H, Blaauw, B & Schiaffino, S 2014, ' Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock ', Molecular Metabolism, vol. 3, no. 1, pp. 29-41 . https://doi.org/10.1016/j.molmet.2013.10.005
Dyar, KA; Ciciliot, S; Wright, LE; Biensø, RS; Tagliazucchi, GM; Patel, VR; et al.(2014). Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock. Molecular Metabolism, 3(1), 29-41. doi: 10.1016/j.molmet.2013.10.005. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/9qt4b2ps
Molecular Metabolism

Circadian rhythms control metabolism and energy homeostasis, but the role of the skeletal muscle clock has never been explored. We generated conditional and inducible mouse lines with muscle-specific ablation of the core clock gene Bmal1. Skeletal mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc93ba9a41406144937d60737c235b1f
http://hdl.handle.net/11577/2836721

Stereoselective synthesis of fluorinated β-aminoacids from ethyl trans-N-benzyl-3-trifluoromethylaziridine-2-carboxylate

Autor: Chiara Franciosi, Irene Moretti, Arrigo Forni, Fabio Prati, Paolo Davoli

Publikováno v: Tetrahedron: Asymmetry. 10:2361-2371

trans-N-Benzyl-3-trifluoromethyl-2-ethoxycarbonylaziridine 2a, easily obtainable in enantiopure forms by CAL-catalysed enzymatic resolution, allowed the regio- and stereoselective synthesis of chiral fluorinated anti-α-functionalised-β-aminoacids,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebb7b76678044c7bec969651bfbed467
https://doi.org/10.1016/s0957-4166(99)00246-3