Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Irene Molina-Gonzalez"'
Autor:
Irene Molina-Gonzalez, Rebecca K. Holloway, Zoeb Jiwaji, Owen Dando, Sarah A. Kent, Katie Emelianova, Amy F. Lloyd, Lindsey H. Forbes, Ayisha Mahmood, Thomas Skripuletz, Viktoria Gudi, James A. Febery, Jeffrey A. Johnson, Jill H. Fowler, Tanja Kuhlmann, Anna Williams, Siddharthan Chandran, Martin Stangel, Andrew J. M. Howden, Giles E. Hardingham, Veronique E. Miron
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Failed regeneration of myelin around neuronal axons following central nervous system damage contributes to nerve dysfunction and clinical decline in various neurological conditions, for which there is an unmet therapeutic demand. Here, we sh
Externí odkaz:
https://doaj.org/article/c24c9e61819a48939d2ddccda235b862
Autor:
Rebecca K. Holloway, Liang Zhang, Irene Molina-Gonzalez, Kathy Ton, James A. R. Nicoll, James P. Boardman, Yan Liang, Anna Williams, Veronique E. Miron
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-15 (2023)
Abstract Myelination of neuronal axons is a critical aspect of central nervous system development and function. However, the fundamental cellular and molecular mechanisms influencing human developmental myelination and its failure are not fully under
Externí odkaz:
https://doaj.org/article/34498bae4a64448fac233d5ac8f7924e
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
In this Perspective, Molina-Gonzalez and co-authors discuss the contribution of oligodendrocyte injury to neurological disease and the potential for their therapeutic targeting.
Externí odkaz:
https://doaj.org/article/b7fc68b702154cb9baea4808e0c3feb5
Autor:
Rocío Rojo, Anna Raper, Derya D. Ozdemir, Lucas Lefevre, Kathleen Grabert, Evi Wollscheid-Lengeling, Barry Bradford, Melanie Caruso, Iveta Gazova, Alejandra Sánchez, Zofia M. Lisowski, Joana Alves, Irene Molina-Gonzalez, Hayk Davtyan, Rebecca J. Lodge, James D. Glover, Robert Wallace, David A. D. Munro, Eyal David, Ido Amit, Véronique E. Miron, Josef Priller, Stephen J. Jenkins, Giles E. Hardingham, Mathew Blurton-Jones, Neil A. Mabbott, Kim M. Summers, Peter Hohenstein, David A. Hume, Clare Pridans
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
The lineage-specific receptor CSF1R controls macrophage development and homeostasis. Here the authors show that deletion of a conserved Csf1r enhancer (FIRE) selectively depletes brain microglia and resident macrophages in the epidermis, kidney, hear
Externí odkaz:
https://doaj.org/article/f7dcb1c551fc424bb8707e117d441d06
Autor:
Niamh B. McNamara, David A. D. Munro, Nadine Bestard-Cuche, Akiko Uyeda, Jeroen F. J. Bogie, Alana Hoffmann, Rebecca K. Holloway, Irene Molina-Gonzalez, Katharine E. Askew, Stephen Mitchell, William Mungall, Michael Dodds, Carsten Dittmayer, Jonathan Moss, Jamie Rose, Stefan Szymkowiak, Lukas Amann, Barry W. McColl, Marco Prinz, Tara L. Spires-Jones, Werner Stenzel, Karen Horsburgh, Jerome J. A. Hendriks, Clare Pridans, Rieko Muramatsu, Anna Williams, Josef Priller, Veronique E. Miron
Publikováno v:
Nature 613(7942), 120-129 (2023). doi:10.1038/s41586-022-05534-y
Myelin is required for the function of neuronal axons in the central nervous system, but the mechanisms that support myelin health are unclear. Although macrophages in the central nervous system have been implicated in myelin health1, it is unknown w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228d404a8611c8450df3d12b1580b5c6
Autor:
Irene Molina-Gonzalez, Rebecca K. Holloway, Zoeb Jiwaji, Owen Dando, Katie Emelianova, Amy F. Lloyd, Lindsey H. Forbes, Ayisha Mahmood, Thomas Skripuletz, Viktoria Gudi, James A. Febery, Jeffrey A. Johnson, Jill H. Fowler, Tanja Kuhlmann, Anna Williams, Siddharthan Chandran, Martin Stangel, Andrew J.M. Howden, Giles E. Hardingham, Veronique E. Miron
SummaryFailed regeneration of myelin around neuronal axons following central nervous system damage contributes to nerve dysfunction and clinical decline in various neurological conditions, for which there is an unmet therapeutic demand1,2. Here, we s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38eb1083540b581d5917ed6649a4fea8
https://doi.org/10.1101/2022.10.04.510850
https://doi.org/10.1101/2022.10.04.510850
Publikováno v:
Molina-Gonzalez, I & Miron, V 2019, ' Astrocytes in myelination and remyelination ', Neuroscience Letters . https://doi.org/10.1016/j.neulet.2019.134532
Astrocytes are known to play critical roles in central nervous system development, homeostasis, and response to injury. In addition to well-defined functions in synaptic signalling and blood-brain barrier control, astrocytes are now emerging as impor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f2882df0ea3be2d7628114ec18651ce
https://www.pure.ed.ac.uk/ws/files/114892274/Molina_Gonzalez_et_al_Neuroscience_Letters_2019_R1.docx
https://www.pure.ed.ac.uk/ws/files/114892274/Molina_Gonzalez_et_al_Neuroscience_Letters_2019_R1.docx
Autor:
Josef Priller, Anna Raper, Lucas Lefevre, Melanie Caruso, Hayk Davtyan, Rebecca J. Lodge, Veronique E. Miron, Barry Bradford, Iveta Gazova, Robert Wallace, Neil A. Mabbott, David A. Hume, Derya D. Ozdemir, Eyal David, Kim M. Summers, Kathleen Grabert, Peter Hohenstein, David A. D. Munro, Mathew Blurton-Jones, Alejandra Sánchez, Giles E. Hardingham, Ido Amit, Rocio Rojo, Joana Alves, Irene Molina-Gonzalez, Zofia M. Lisowski, Clare Pridans, Stephen J. Jenkins, Evi Wollscheid-Lengeling, James D. Glover
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications, 10. NATURE PUBLISHING GROUP
Nature Communications
Rojo, R, Raper, A, Ozdemir, D D, Lefevre, L, Grabert, K, Wollscheid-Lengeling, E, Bradford, B, Caruso, M, Gazova, I, Sanchez, A, Lisowski, Z M, Alves, J, Molina-Gonzalez, I, Davtyan, H, Lodge, R J, Glover, J D, Wallace, R, Munro, D A D, David, E, Amit, I, Miron, V E, Priller, J, Jenkins, S J, Hardingham, G E, Blurton-Jones, M, Mabbott, N A, Summers, K M, Hohenstein, P, Hume, D A & Pridans, C 2019, ' Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations. ', Nature Communications, vol. 10, 3215 . https://doi.org/10.1038/s41467-019-11053-8
Nature Communications, 10. NATURE PUBLISHING GROUP
Nature Communications
Rojo, R, Raper, A, Ozdemir, D D, Lefevre, L, Grabert, K, Wollscheid-Lengeling, E, Bradford, B, Caruso, M, Gazova, I, Sanchez, A, Lisowski, Z M, Alves, J, Molina-Gonzalez, I, Davtyan, H, Lodge, R J, Glover, J D, Wallace, R, Munro, D A D, David, E, Amit, I, Miron, V E, Priller, J, Jenkins, S J, Hardingham, G E, Blurton-Jones, M, Mabbott, N A, Summers, K M, Hohenstein, P, Hume, D A & Pridans, C 2019, ' Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations. ', Nature Communications, vol. 10, 3215 . https://doi.org/10.1038/s41467-019-11053-8
The proliferation, differentiation and survival of mononuclear phagocytes depend on signals from the receptor for macrophage colony-stimulating factor, CSF1R. The mammalian Csf1r locus contains a highly conserved super-enhancer, the fms-intronic regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c3693a39f65abf35033f4274fb63d13
http://orbilu.uni.lu/handle/10993/50393
http://orbilu.uni.lu/handle/10993/50393