Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Irene Miguel-Aliaga"'
Autor:
Jose M. Ramos-Pittol, Isabel Fernandes-Freitas, Alexandra Milona, Stephen M. Manchishi, Kara Rainbow, Brian Y. H. Lam, John A. Tadross, Anthony Beucher, William H. Colledge, Inês Cebola, Kevin G. Murphy, Irene Miguel-Aliaga, Giles S. H. Yeo, Waljit S. Dhillo, Bryn M. Owen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Coupling the release of pituitary hormones to the developmental stage of the oocyte is essential for female fertility. It requires estrogen to restrain kisspeptin (KISS1)-neuron pulsatility in the arcuate hypothalamic nucleus, while also exe
Externí odkaz:
https://doaj.org/article/59195b68a82445d591a6b19294b35586
Autor:
Alexandra Milona, Vittoria Massafra, Harmjan Vos, Jyoti Naik, Natalia Artigas, Helen A.B. Paterson, Ingrid T.G.W. Bijsmans, Ellen C.L. Willemsen, Jose M. Ramos Pittol, Irene Miguel-Aliaga, Piter Bosma, Boudewijn M.T. Burgering, Catherine Williamson, Santiago Vernia, Waljit S. Dhillo, Saskia W.C. van Mil, Bryn M. Owen
Publikováno v:
Molecular Metabolism, Vol 30, Iss , Pp 221-229 (2019)
Objective: Coupling metabolic and reproductive pathways is essential for the survival of species. However, the functions of steroidogenic enzymes expressed in metabolic tissues are largely unknown. Methods and results: Here, we show that in the liver
Externí odkaz:
https://doaj.org/article/f03fe7de90804886b4db2443d1f7e1c8
Autor:
Jason W Millington, George P Brownrigg, Charlotte Chao, Ziwei Sun, Paige J Basner-Collins, Lianna W Wat, Bruno Hudry, Irene Miguel-Aliaga, Elizabeth J Rideout
Publikováno v:
eLife, Vol 10 (2021)
Nutrient-dependent body size plasticity differs between the sexes in most species, including mammals. Previous work in Drosophila showed that body size plasticity was higher in females, yet the mechanisms underlying increased female body size plastic
Externí odkaz:
https://doaj.org/article/87937031a5ad4c95a74d6993ab80b4a4
Publikováno v:
PLoS Genetics, Vol 14, Iss 2, p e1007203 (2018)
Reproduction in sexually dimorphic animals relies on successful gamete production, executed by the germline and aided by somatic support cells. Somatic sex identity in Drosophila is instructed by sex-specific isoforms of the DMRT1 ortholog Doublesex
Externí odkaz:
https://doaj.org/article/1a62b6363e8b4722845390ab3f57bf66
Autor:
Tobias Reiff, Jake Jacobson, Paola Cognigni, Zeus Antonello, Esther Ballesta, Kah Junn Tan, Joanne Y Yew, Maria Dominguez, Irene Miguel-Aliaga
Publikováno v:
eLife, Vol 4 (2015)
The production of offspring is energetically costly and relies on incompletely understood mechanisms that generate a positive energy balance. In mothers of many species, changes in key energy-associated internal organs are common yet poorly character
Externí odkaz:
https://doaj.org/article/6302a9c5427f4c098b2d1bf012cfe315
Autor:
Peter Soba, Chun Han, Yi Zheng, Daniel Perea, Irene Miguel-Aliaga, Lily Yeh Jan, Yuh Nung Jan
Publikováno v:
eLife, Vol 4 (2015)
Neurons develop highly stereotyped receptive fields by coordinated growth of their dendrites. Although cell surface cues play a major role in this process, few dendrite specific signals have been identified to date. We conducted an in vivo RNAi scree
Externí odkaz:
https://doaj.org/article/bb0b61f3b03a4b88a6604302b80627b1
Autor:
Òscar Martorell, Anna Merlos-Suárez, Kyra Campbell, Francisco M Barriga, Christo P Christov, Irene Miguel-Aliaga, Eduard Batlle, Jordi Casanova, Andreu Casali
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88413 (2014)
Whereas the series of genetic events leading to colorectal cancer (CRC) have been well established, the precise functions that these alterations play in tumor progression and how they disrupt intestinal homeostasis remain poorly characterized. Activa
Externí odkaz:
https://doaj.org/article/09543f861e1840338d2c3672816bc0e2
Publikováno v:
PLoS Biology, Vol 6, Iss 3, p e58 (2008)
Insulin and related peptides play important and conserved functions in growth and metabolism. Although Drosophila has proved useful for the genetic analysis of insulin functions, little is known about the transcription factors and cell lineages invol
Externí odkaz:
https://doaj.org/article/3d7c53f2520d4ebd98076fa9aca3e694
Publikováno v:
PLoS Biology, Vol 5, Iss 2, p e37 (2007)
Neuronal specification is often seen as a multistep process: earlier regulators confer broad neuronal identity and are followed by combinatorial codes specifying neuronal properties unique to specific subtypes. However, it is still unclear whether ea
Externí odkaz:
https://doaj.org/article/95b388e9295b4f92b3d6db08a4f17875
Autor:
Emily Strachan, Irene Miguel-Aliaga
Publikováno v:
Nature. 617:677-678