Zero-field nuclear magnetic resonance of chemically exchanging systems

Autor: Danila A. Barskiy, Michael C. D. Tayler, Irene Marco-Rius, John Kurhanewicz, Daniel B. Vigneron, Sevil Cikrikci, Ayca Aydogdu, Moritz Reh, Andrey N. Pravdivtsev, Jan-Bernd Hövener, John W. Blanchard, Teng Wu, Dmitry Budker, Alexander Pines

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)

Zero-field nuclear magnetic resonance can identify species and collective behaviors in mixtures without applied magnetic fields. Here the authors demonstrate its use for resolving proton exchange in ammonium and for the detection of hyperpolarized py

Externí odkaz: https://doaj.org/article/58e06c5dcabe4e329f3f3e6e1d38ac26

Non-invasive detection of divergent metabolic signals in insulin deficiency vs. insulin resistance in vivo

Autor: Cornelius von Morze, Prasanna K. R. Allu, Gene Y. Chang, Irene Marco-Rius, Eugene Milshteyn, Zhen J. Wang, Michael A. Ohliger, Catherine E. Gleason, John Kurhanewicz, Daniel B. Vigneron, David Pearce

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)

Abstract The type 2 diabetic phenotype results from mixed effects of insulin deficiency and insulin resistance, but the relative contributions of these two distinct factors remain poorly characterized, as do the respective roles of the gluconeogenic

Externí odkaz: https://doaj.org/article/0da58e9c958344c2a4144ef02696a579

Ammonium quantification in human plasma by proton nuclear magnetic resonance for staging of liver fibrosis in alcohol-related liver disease and nonalcoholic fatty liver disease

Autor: Marc Azagra, Elisa Pose, Francesco De Chiara, Martina Perez, Emma Avitabile, Joan‐Marc Servitja, Laura Brugnara, Javier Ramon‐Azcón, Irene Marco‐Rius

Publikováno v: NMR in biomedicine. 35(9)

Liver fibrosis staging is a key element driving the prognosis of patients with chronic liver disease. Currently, biopsy is the only technique capable of diagnosing liver fibrosis in patients with alcohol-related liver disease (ArLD) and nonalcoholic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de9e88d086228b20a7d060657d72d9d5
https://pubmed.ncbi.nlm.nih.gov/35435283

Labile Photo‐Induced Free Radical in α‐Ketoglutaric Acid: a Universal Endogenous Polarizing Agent for In Vivo Hyperpolarized 13 C Magnetic Resonance

Autor: Irene Marco-Rius, Tian Cheng, Kevin M. Brindle, Jennifer S Lewis, Friederike Hesse, Adam P. Gaunt, Arnaud Comment

Publikováno v: Angew Chem Int Ed Engl

Hyperpolarized (HP)(13)C magnetic resonance enables non-invasive probing of metabolism in vivo. To date, only (13)C-molecules hyperpolarized with persistent trityl radicals have been injected in humans. We show here that the free radical photo-induce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29977a9b9419de57d3f852221a42e231
https://doi.org/10.1002/ange.202112982

Probing hepatic metabolism of [2-13C]dihydroxyacetone in vivo with 1H-decoupled hyperpolarized 13C-MR

Autor: Irene Marco-Rius, Alan J. Wright, De-en Hu, Dragana Savic, Jack J. Miller, Kerstin N. Timm, Damian Tyler, Kevin M. Brindle, Arnaud Comment

Publikováno v: Marco-Rius, I, Wright, A J, Hu, D E, Savic, D, Miller, J J, Timm, K N, Tyler, D, Brindle, K M & Comment, A 2020, ' Probing hepatic metabolism of [2-13 C]dihydroxyacetone in vivo with 1 H-decoupled hyperpolarized 13 C-MR ', Magnetic Resonance Materials in Physics, Biology and Medicine . https://doi.org/10.1007/s10334-020-00884-y
MAGMA

Objectives To enhance detection of the products of hyperpolarized [2-13C]dihydroxyacetone metabolism for assessment of three metabolic pathways in the liver in vivo. Hyperpolarized [2-13C]DHAc emerged as a promising substrate to follow gluconeogenesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c89cb5ada2a9c6232a3caf0154e820
https://pure.au.dk/portal/da/publications/probing-hepatic-metabolism-of-213cdihydroxyacetone-in-vivo-with-1hdecoupled-hyperpolarized-13cmr(5252133f-69a9-4439-a590-76ae836803af).html