Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Irene M. Purcell"'
Autor:
Irene M. Purcell, Teresa M. Schelhorn, William F. Holt, S S Ellery, Wester Ronald Thure, William R. Murphy, Michael L. Mangiapane, Kelly A. Simpson, Andrew H. Smith
Publikováno v:
Drug Development Research. 34:361-368
Human and monkey renin are very similar, but differ from the renin of species commonly used in screening antihypertensive agents (i.e., dog and rat). This has necessitated the evaluation of renin inhibitors (Rls) in primate models. We have found that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82f26bf0a751ac21850b65adcd8c46a7
https://doi.org/10.1002/ddr.430340408
https://doi.org/10.1002/ddr.430340408
Autor:
William F. Holt, M.A. Ravi Kiron, Robert L. Rosati, Kleinman Edward F, Andrew H. Fray, Irene M. Purcell, William R. Murphy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:589-592
CP-71,362 (Boc-Phe-His-hexahydroPhe[OH]Leu-Lys-Phe) has been identified as the most potent inhibitor of rat plasma renin (IC50 = 3 nM) and dog plasma renin (IC50 = 3 pM) to date and thus can be used as an important experimental tool in the study of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb1fae6b40c19de1b4412f1a44c47c9e
https://doi.org/10.1016/s0960-894x(01)80160-8
https://doi.org/10.1016/s0960-894x(01)80160-8
Autor:
Joseph T. MacAndrew, William F. Holt, S S Ellery, William R. Murphy, Irene M. Purcell, Kleinman Edward F, Andrew H. Smith, Michael L. Mangiapane
Publikováno v:
Clinical and Experimental Hypertension. 16:507-533
Most renin inhibitors are primate-specific. In the present paper, we describe the effects of CP-71,362, a pentapeptide which preferentially inhibits canine (and to a lesser extent, rat) plasma renin. Vs. the canine enzyme, its affinity (IC50 = 3.3 x
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d7c7cb6cfe967135ad86d1fed081e3
https://doi.org/10.3109/10641969409067959
https://doi.org/10.3109/10641969409067959
Autor:
Dennis J. Hoover, Donald E. Wilder, Teresa M. Schelhorn, Andrew H. Smith, Joseph T. MacAndrew, William F. Holt, Wester Ronald Thure, Irene M. Purcell, Robert L. Rosati, William R. Murphy
Publikováno v:
Amino Acids ISBN: 9789072199041
CP-80,794 is a potent, modified dipeptide inhibitor of human renin (in vitro, ICSO = 0.7 ± 0.1 nM). Inhibitory potency (ICso) against plasma renin of guinea pigs, dogs and monkeys ranges from 0.3 to 0.7 nM allowing for evaluation of blood pressure l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::485f3b7d6a37b004f321a97bcf88aa7e
https://doi.org/10.1007/978-94-011-2262-7_81
https://doi.org/10.1007/978-94-011-2262-7_81
Publikováno v:
Atherosclerosis. 16:31-36
Arterial thrombosis was induced in anesthetized dogs by inverting a branch of the carotid or femoral artery into the lumen of the main vessel to cause endothelial damage without introducing foreign material into the circulation. Platelet-fibrin throm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50e22c46b9578c21a68d2b928a79a334
https://doi.org/10.1016/0021-9150(72)90005-6
https://doi.org/10.1016/0021-9150(72)90005-6
Autor:
Jay W. Constantine, Irene M. Purcell
Publikováno v:
Thromboembolism ISBN: 9789401161466
Thromboembolism
Thromboembolism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7a7f48b94b905ec91d2ea1338ea664b
https://doi.org/10.1007/978-94-011-6144-2_7
https://doi.org/10.1007/978-94-011-6144-2_7
Autor:
Jay W. Constantine, Irene M. Purcell
Publikováno v:
Nature. 235(5338)
HAEMORRHAGE in scurvy has been attributed to increased capillary fragility caused by reduced collagen formation1 and consequent changes in vascular endothelium and perivascular connective tissue2–4. Platelet adhesiveness to glass is impaired in hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dbfdee4fb7d1467b97f8414bf902383
https://pubmed.ncbi.nlm.nih.gov/4551643
https://pubmed.ncbi.nlm.nih.gov/4551643