Zobrazeno 1 - 10
of 376
pro vyhledávání: '"Irene M. Leigh"'
Autor:
Peter Bailey, Rachel A. Ridgway, Patrizia Cammareri, Mairi Treanor-Taylor, Ulla-Maja Bailey, Christina Schoenherr, Max Bone, Daniel Schreyer, Karin Purdie, Jason Thomson, William Rickaby, Rene Jackstadt, Andrew D. Campbell, Emmanouil Dimonitsas, Alexander J. Stratigos, Sarah T. Arron, Jun Wang, Karen Blyth, Charlotte M. Proby, Catherine A. Harwood, Owen J. Sansom, Irene M. Leigh, Gareth J. Inman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract The molecular basis of disease progression from UV-induced precancerous actinic keratosis (AK) to malignant invasive cutaneous squamous cell carcinoma (cSCC) and potentially lethal metastatic disease remains unclear. DNA sequencing studies h
Externí odkaz:
https://doaj.org/article/12b4077a59444dd3949da320a9c0d1e9
Autor:
Frederic Li Mow Chee, Bruno Beernaert, Billie G. C. Griffith, Alexander E. P. Loftus, Yatendra Kumar, Jimi C. Wills, Martin Lee, Jessica Valli, Ann P. Wheeler, J. Douglas Armstrong, Maddy Parsons, Irene M. Leigh, Charlotte M. Proby, Alex von Kriegsheim, Wendy A. Bickmore, Margaret C. Frame, Adam Byron
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Cells transmit mechanical force to the nucleus via the cytoskeleton. Here, the authors reveal a role for the actin regulator Mena in force transmission at the nuclear envelope, where it regulates nuclear architecture, chromatin organization and gene
Externí odkaz:
https://doaj.org/article/c362f4cc95db4024a0d3eb4b310fffac
Autor:
Gareth J. Inman, Jun Wang, Ai Nagano, Ludmil B. Alexandrov, Karin J. Purdie, Richard G. Taylor, Victoria Sherwood, Jason Thomson, Sarah Hogan, Lindsay C. Spender, Andrew P. South, Michael Stratton, Claude Chelala, Catherine A. Harwood, Charlotte M. Proby, Irene M. Leigh
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
It is known cutaneous squamous cell carcinoma (cSCC) involves a high tumour mutation burden. Here the authors identify common cSCC mutated genes, copy number changes, altered pathways and report the presence of a novel mutation signature associated w
Externí odkaz:
https://doaj.org/article/d162fea7f7de4883a5d53f89f08c61a7
Autor:
Thiviyani Maruthappu, Anissa Chikh, Benjamin Fell, Paul J. Delaney, Matthew A. Brooke, Clemence Levet, Angela Moncada-Pazos, Akemi Ishida-Yamamoto, Diana Blaydon, Ahmad Waseem, Irene M. Leigh, Matthew Freeman, David P. Kelsell
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Keratin 16 is an epithelial protein highly expressed at pressure bearing sites and during wound healing and cancer. Here the authors show that K16 interacts with the inactive protease Rhbdf2, associated with Tylosis with oesophageal cancer, and that
Externí odkaz:
https://doaj.org/article/b4cfedfe8b0b4b1e98605a9262df868a
Autor:
Viviana Mannella, Kira Boehm, Suheyla Celik, Tasnim Ali, Amnah N. Mirza, Mariam El Hasnaouy, Andreas Kaffa, Yanshuang Lyu, Donya Kafaei Golahmadi, Irene M. Leigh, Daniele Bergamaschi, Catherine A. Harwood, Tania Maffucci
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7, p 3567 (2021)
Cutaneous squamous cell carcinomas (cSCCs) account for about 20% of keratinocyte carcinomas, the most common cancer in the UK. Therapeutic options for cSCC patients who develop metastasis are limited and a better understanding of the biochemical path
Externí odkaz:
https://doaj.org/article/d1735ca0cd714d07acbd88891bfd7116
Autor:
Patrizia Cammareri, Aidan M. Rose, David F. Vincent, Jun Wang, Ai Nagano, Silvana Libertini, Rachel A. Ridgway, Dimitris Athineos, Philip J. Coates, Angela McHugh, Celine Pourreyron, Jasbani H. S. Dayal, Jonas Larsson, Simone Weidlich, Lindsay C. Spender, Gopal P. Sapkota, Karin J. Purdie, Charlotte M. Proby, Catherine A. Harwood, Irene M. Leigh, Hans Clevers, Nick Barker, Stefan Karlsson, Catrin Pritchard, Richard Marais, Claude Chelala, Andrew P. South, Owen J. Sansom, Gareth J. Inman
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Cutaneous squamous cell carcinomas is a growing problem but the driver genes causing this remain poorly defined. Here, the authors demonstrate that inactivating driver mutations in TGFBR1 and TGFBR2occur in vemurafenib-induced and sporadic cutaneous
Externí odkaz:
https://doaj.org/article/007e4295faa9467ba2f947c4d342dc0a
Autor:
Karin J. Purdie, Charlotte M. Proby, Hasan Rizvi, Heather Griffin, John Doorbar, Mary Sommerlad, Mariet C. Feltkamp, Els Van der Meijden, Gareth J. Inman, Andrew P. South, Irene M. Leigh, Catherine A. Harwood
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Background: Human papillomavirus (HPV) has long been proposed as a cofactor in the pathogenesis of cutaneous squamous cell carcinoma (cSCC). More recently, the striking clinico-pathological features of cSCCs that complicate treatment of metastatic me
Externí odkaz:
https://doaj.org/article/ae66638460604f449b4582a92dea391f
Autor:
Sakinah Hassan, Karin J. Purdie, Jun Wang, Catherine A. Harwood, Charlotte M. Proby, Celine Pourreyron, Nikol Mladkova, Ai Nagano, Sandeep Dhayade, Dimitris Athineos, Matthew Caley, Viviana Mannella, Karen Blyth, Gareth J. Inman, Irene M. Leigh
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 14, p 3428 (2019)
Background: Cutaneous squamous cell carcinoma (cSCC) incidence continues to rise with increasing morbidity and mortality, with limited treatment options for advanced disease. Future improvements in targeted therapy will rely on advances in genomic/tr
Externí odkaz:
https://doaj.org/article/98119bebc7214a0dae59214416994d70
Autor:
Andrew P. South, E. Birgit Lane, Irene M. Leigh, Dedee F. Murrell, John A. McGrath, Fiona J. Hogg, Jo-David Fine, Mei Chen, Sheila Wright, Wenfei Yan, Rodrigo Cepeda-Valdes, Jasbani H.S. Dayal, Julio C. Salas-Alanis, Celine Pourreyron, Yi-Zhen Ng
PDF file - 56K, Unsupervised clustering of the core serum response gene set is able to cluster NHF but not RDEBSCCF sample groups in culture
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72974951fc1ba8170619c1a8aee8e69a
https://doi.org/10.1158/0008-5472.22393518
https://doi.org/10.1158/0008-5472.22393518
Autor:
Andrew P. South, E. Birgit Lane, Irene M. Leigh, Dedee F. Murrell, John A. McGrath, Fiona J. Hogg, Jo-David Fine, Mei Chen, Sheila Wright, Wenfei Yan, Rodrigo Cepeda-Valdes, Jasbani H.S. Dayal, Julio C. Salas-Alanis, Celine Pourreyron, Yi-Zhen Ng
XLS file - 36K, Table describing the patient samples used in this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f4b8a87b05e77dffca40779748b7faa
https://doi.org/10.1158/0008-5472.22393497
https://doi.org/10.1158/0008-5472.22393497