Zobrazeno 1 - 10
of 797
pro vyhledávání: '"Irene M. Ghobrial"'
Autor:
Lama Hasan Bou Issa, Léa Fléchon, William Laine, Aicha Ouelkdite, Silvia Gaggero, Adeline Cozzani, Remi Tilmont, Paul Chauvet, Nicolas Gower, Romanos Sklavenitis-Pistofidis, Carine Brinster, Xavier Thuru, Yasmine Touil, Bruno Quesnel, Suman Mitra, Irene M. Ghobrial, Jérôme Kluza, Salomon Manier
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109417- (2024)
Summary: Multiple myeloma (MM) is an incurable hematological malignancy in which MYC alterations contribute to the malignant phenotype. Nevertheless, MYC lacks therapeutic druggability. Here, we leveraged large-scale loss-of-function screens and cond
Externí odkaz:
https://doaj.org/article/72ba85726c1743d3bf9ab81236b28b94
Autor:
Rebecca Boiarsky, Nicholas J. Haradhvala, Jean-Baptiste Alberge, Romanos Sklavenitis-Pistofidis, Tarek H. Mouhieddine, Oksana Zavidij, Ming-Chieh Shih, Danielle Firer, Mendy Miller, Habib El-Khoury, Shankara K. Anand, François Aguet, David Sontag, Irene M. Ghobrial, Gad Getz
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Development of multiple myeloma is preceded by precursor conditions. Here, the authors use single cell RNA-sequencing of plasma cells from patients across disease stages to identify genomic signatures present even at the earliest stages of disease.
Externí odkaz:
https://doaj.org/article/9d414d529e9c47048ee140321dbb3a8c
Autor:
Mark Bustoros, Shankara Anand, Romanos Sklavenitis-Pistofidis, Robert Redd, Eileen M. Boyle, Benny Zhitomirsky, Andrew J. Dunford, Yu-Tzu Tai, Selina J. Chavda, Cody Boehner, Carl Jannes Neuse, Mahshid Rahmat, Ankit Dutta, Tineke Casneuf, Raluca Verona, Efstathis Kastritis, Lorenzo Trippa, Chip Stewart, Brian A. Walker, Faith E. Davies, Meletios-Athanasios Dimopoulos, P. Leif Bergsagel, Kwee Yong, Gareth J. Morgan, François Aguet, Gad Getz, Irene M. Ghobrial
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Existing clinical models cannot fully capture smoldering multiple myeloma (SMM) heterogeneity. Here, integration of 42 genetic alterations from 214 SMM patients using an unsupervised binary matrix factorization clustering approach results in the iden
Externí odkaz:
https://doaj.org/article/078805a3b909435fb477a229095a08ed
Type I interferons augment regulatory T cell polarization in concert with ancillary cytokine signals
Autor:
Siawosh K. Eskandari, Hazim Allos, Jenelle M. Safadi, Ina Sulkaj, Jan S. F. Sanders, Paolo Cravedi, Irene M. Ghobrial, Stefan P. Berger, Jamil R. Azzi
Publikováno v:
Frontiers in Transplantation, Vol 2 (2023)
In the transplant community, research efforts exploring endogenous alternatives to inducing tolerogenic allo-specific immune responses are much needed. In this regard, CD4 + FoxP3+ regulatory T cells (Tregs) are appealing candidates due to their intr
Externí odkaz:
https://doaj.org/article/b50d639c88f04efb89352c7184a93f92
Autor:
Margaret Hallisey, Jenna Dennis, Charlotte Abrecht, Romanos Sklavenitis Pistofidis, Abigail N. Schork, Elizabeth D. Lightbody, Daniel Heilpern-Mallory, Mariano Severgnini, Irene M. Ghobrial, F. Stephen Hodi, Joanna Baginska
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101163- (2022)
Summary: This protocol details a staining technique optimized for immunophenotyping of human bone marrow immune populations using mass cytometry. The protocol accounts for the limitations of working with human bone marrow, such as reduced viability,
Externí odkaz:
https://doaj.org/article/742388b8e446429081c2e354f4ece9c6
Autor:
Paul G. Richardson, Arnon Nagler, Dina Ben‐Yehuda, Ashraf Badros, Parameswaran N. Hari, Roman Hajek, Ivan Spicka, Hakan Kaya, Richard LeBlanc, Sung‐Soo Yoon, Kihyun Kim, Joaquin Martinez‐Lopez, Moshe Mittelman, Ofer Shpilberg, Paul Blake, Teru Hideshima, Kathleen Colson, Jacob P. Laubach, Irene M. Ghobrial, Merav Leiba, Moshe E. Gatt, Peter Sportelli, Michael Chen, Kenneth C. Anderson
Publikováno v:
eJHaem, Vol 1, Iss 1, Pp 94-102 (2020)
Abstract Perifosine, an investigational, oral, synthetic alkylphospholipid, inhibits signal transduction pathways of relevance in multiple myeloma (MM) including PI3K/Akt. Perifosine demonstrated anti‐MM activity in preclinical studies and encourag
Externí odkaz:
https://doaj.org/article/4446319b4078465e9e6ff60dab4bc36c
Autor:
Tarek H. Mouhieddine, Adam S. Sperling, Robert Redd, Jihye Park, Matthew Leventhal, Christopher J. Gibson, Salomon Manier, Amin H. Nassar, Marzia Capelletti, Daisy Huynh, Mark Bustoros, Romanos Sklavenitis-Pistofidis, Sabrin Tahri, Kalvis Hornburg, Henry Dumke, Muhieddine M. Itani, Cody J. Boehner, Chia-Jen Liu, Saud H. AlDubayan, Brendan Reardon, Eliezer M. Van Allen, Jonathan J. Keats, Chip Stewart, Shaadi Mehr, Daniel Auclair, Robert L. Schlossman, Nikhil C. Munshi, Kenneth C. Anderson, David P. Steensma, Jacob P. Laubach, Paul G. Richardson, Jerome Ritz, Benjamin L. Ebert, Robert J. Soiffer, Lorenzo Trippa, Gad Getz, Donna S. Neuberg, Irene M. Ghobrial
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Multiple myeloma (MM) is treated with induction chemotherapy, autologous stem cell transplant (ASCT) and long-term immunomodulatory drug (IMiD) maintenance. Here, the authors show that the presence of clonal haematopoiesis of indeterminate potential
Externí odkaz:
https://doaj.org/article/26a4f18ed00849e6bce820eacad6b32d
Publikováno v:
HemaSphere, Vol 3, Pp 121-123 (2019)
Externí odkaz:
https://doaj.org/article/140802aad2f0452ab78f3be57eb9691a
Autor:
Yuji Mishima, Bruno Paiva, Jiantao Shi, Jihye Park, Salomon Manier, Satoshi Takagi, Mira Massoud, Adriana Perilla-Glen, Yosra Aljawai, Daisy Huynh, Aldo M. Roccaro, Antonio Sacco, Marzia Capelletti, Alexandre Detappe, Diego Alignani, Kenneth C. Anderson, Nikhil C. Munshi, Felipe Prosper, Jens G. Lohr, Gavin Ha, Samuel S. Freeman, Eliezer M. Van Allen, Viktor A. Adalsteinsson, Franziska Michor, Jesus F. San Miguel, Irene M. Ghobrial
Publikováno v:
Cell Reports, Vol 19, Iss 1, Pp 218-224 (2017)
The development of sensitive and non-invasive “liquid biopsies” presents new opportunities for longitudinal monitoring of tumor dissemination and clonal evolution. The number of circulating tumor cells (CTCs) is prognostic in multiple myeloma (MM
Externí odkaz:
https://doaj.org/article/0ab1ac700cc547768b8dbcbc3419651a
Publikováno v:
Cancers, Vol 12, Iss 6, p 1554 (2020)
Monoclonal Gammopathy of Undetermined Significance (MGUS) is considered to be a benign precursor condition that may progress to a lymphoproliferative disease or multiple myeloma. Most patients do not progress to an overt condition, but nevertheless,
Externí odkaz:
https://doaj.org/article/7ebd4144bd1a4ddbb0279e3af9d1a248