Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Irene M Kaplow"'
Autor:
Alyssa J Lawler, Easwaran Ramamurthy, Ashley R Brown, Naomi Shin, Yeonju Kim, Noelle Toong, Irene M Kaplow, Morgan Wirthlin, Xiaoyu Zhang, BaDoi N Phan, Grant A Fox, Kirsten Wade, Jing He, Bilge Esin Ozturk, Leah C Byrne, William R Stauffer, Kenneth N Fish, Andreas R Pfenning
Publikováno v:
eLife, Vol 11 (2022)
Recent discoveries of extreme cellular diversity in the brain warrant rapid development of technologies to access specific cell populations within heterogeneous tissue. Available approaches for engineering-targeted technologies for new neuron subtype
Externí odkaz:
https://doaj.org/article/95df1d9dbb294e8484fc20dc51bd5aec
Autor:
Irene M. Kaplow, Daniel E. Schäffer, Morgan E. Wirthlin, Alyssa J. Lawler, Ashley R. Brown, Michael Kleyman, Andreas R. Pfenning
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-23 (2022)
Abstract Background Evolutionary conservation is an invaluable tool for inferring functional significance in the genome, including regions that are crucial across many species and those that have undergone convergent evolution. Computational methods
Externí odkaz:
https://doaj.org/article/7743500a21774d7b96b13f84255422c2
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-16 (2022)
Abstract Background Many transcription factors (TFs), such as multi zinc-finger (ZF) TFs, have multiple DNA binding domains (DBDs), and deciphering the DNA binding motifs of individual DBDs is a major challenge. One example of such a TF is CCCTC-bind
Externí odkaz:
https://doaj.org/article/022fa4c00ac8437e81c338a17703ff89
Autor:
Josh Tycko, Michael Wainberg, Georgi K. Marinov, Oana Ursu, Gaelen T. Hess, Braeden K. Ego, Aradhana, Amy Li, Alisa Truong, Alexandro E. Trevino, Kaitlyn Spees, David Yao, Irene M. Kaplow, Peyton G. Greenside, David W. Morgens, Douglas H. Phanstiel, Michael P. Snyder, Lacramioara Bintu, William J. Greenleaf, Anshul Kundaje, Michael C. Bassik
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Off-target effects in CRISPR screens for essential regulatory elements have not been systematically evaluated. Here the authors find Cas9 nuclease, CRISPRi/a each have distinct off-target effects, and that these can be accurately identified and remov
Externí odkaz:
https://doaj.org/article/fc5611c303ab470e9fff314f00d1301c
Autor:
Easwaran Ramamurthy, Snigdha Agarwal, Noelle Toong, Irene M. Kaplow, BaDoi Phan, Andreas R. Pfenning
Alzheimer’s disease (AD) involves aggregation of amyloid β and tau, neuron loss, cognitive decline, and neuroinflammatory responses. Both resident microglia and peripheral immune cells have been associated with the immune component of AD. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cc430ab1c42163531e6fb1cacf13626
https://doi.org/10.1101/2022.12.02.518903
https://doi.org/10.1101/2022.12.02.518903
Autor:
Ashley R. Brown, Grant A. Fox, Irene M. Kaplow, Alyssa J. Lawler, BaDoi N. Phan, Morgan E. Wirthlin, Easwaran Ramamurthy, Gemma E. May, Ziheng Chen, Qiao Su, C. Joel McManus, Andreas R. Pfenning
Genetic studies are rapidly identifying non-protein-coding human disease-associated loci. Understanding the regulatory mechanisms underlying these loci remains a challenge because the causal variants and the tissues in which they act are often unclea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20d3fd569187d296363d78bc2809699e
https://doi.org/10.1101/2022.11.23.517755
https://doi.org/10.1101/2022.11.23.517755
Autor:
Noelle Toong, Teresa A. Spix, Irene M. Kaplow, Yazel Goksen, Andreas R. Pfenning, Brian R. Isett, Shruti Nanivadekar, Aryn H. Gittis
Publikováno v:
Science. 374:201-206
Symptoms of neurological diseases emerge through the dysfunction of neural circuits whose diffuse and intertwined architectures pose serious challenges for delivering therapies. Deep brain stimulation (DBS) improves Parkinson’s disease symptoms acu
Autor:
Michael Kleyman, Andreas R. Pfenning, Alyssa J. Lawler, Easwaran Ramamurthy, Irene M. Kaplow, Ashley R. Brown, Morgan Wirthlin, BaDoi N. Phan, Chaitanya Srinivasan
Publikováno v:
The Journal of Neuroscience
Recent large genome-wide association studies (GWAS) have identified multiple confident risk loci linked to addiction-associated behavioral traits. Genetic variants linked to addiction-associated traits lie largely in non-coding regions of the genome,
Autor:
Alyssa J Lawler, Easwaran Ramamurthy, Ashley R Brown, Naomi Shin, Yeonju Kim, Noelle Toong, Irene M Kaplow, Morgan Wirthlin, Xiaoyu Zhang, BaDoi N Phan, Grant A Fox, Kirsten Wade, Jing He, Bilge Esin Ozturk, Leah C Byrne, William R Stauffer, Kenneth N Fish, Andreas R Pfenning
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0af02d8d0949a0762b576362bce53291
https://doi.org/10.7554/elife.69571.sa2
https://doi.org/10.7554/elife.69571.sa2
BackgroundMany transcription factors (TFs), such as multi zinc-finger (ZF) TFs, have multiple DNA binding domains (DBDs) with multiple components, and deciphering the DNA binding motifs of individual components is a major challenge. One example of su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8129cf59190cc91108c5fb3fda9a6909
https://doi.org/10.1101/2021.09.23.461552
https://doi.org/10.1101/2021.09.23.461552