Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Irene Litosch"'
Autor:
Irene Litosch
Publikováno v:
Life Sciences. 152:99-106
Gαq signals with phospholipase C-β (PLC-β) to modify behavior in response to an agonist-bound GPCR. While the fundamental steps which prime Gαq to interact with PLC-β have been identified, questions remain concerning signal strength with PLC-β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4399ee77f179c2930b92bd1f6d7ff928
https://doi.org/10.1016/j.lfs.2016.03.037
https://doi.org/10.1016/j.lfs.2016.03.037
Autor:
Irene Litosch
Publikováno v:
IUBMB Life. 65:936-940
How cells regulate Gq efficacy (initiation and termination of Gq signaling) to effect response remains a central question in pharmacology and drug discovery. Phospholipase C-β1 (PLC-β1) is an effector and a GTPase activating protein (GAP) specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6621f4af850a529ba2785192278742e2
https://doi.org/10.1002/iub.1218
https://doi.org/10.1002/iub.1218
Autor:
Irene Litosch
Publikováno v:
Biochemical and Biophysical Research Communications. 417:956-960
Cellular response to G(q)-linked agonists is shaped by regulatory inputs which determine signal strength and duration. Stimulation of phospholipase C-β (PLC-β) lipase activity results in an increase in the levels of diacylglycerol (DAG) and activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6da297874d5d2fc8f72c17b3512e110f
https://doi.org/10.1016/j.bbrc.2011.12.037
https://doi.org/10.1016/j.bbrc.2011.12.037
Autor:
Irene Litosch
Publikováno v:
Biochemical and Biophysical Research Communications. 415:215-219
Heterotrimeric G proteins have a critical role in mediating signal transduction by ligand-stimulated GPCRs. While activation of heterotrimeric G proteins is known to proceed via the G protein guanine nucleotide cycle, there is much uncertainty regard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27458cb019bde5e3a60818d310828413
https://doi.org/10.1016/j.bbrc.2011.10.063
https://doi.org/10.1016/j.bbrc.2011.10.063
Autor:
Irene Litosch
Publikováno v:
Biochemical and Biophysical Research Communications. 390:603-607
Phosphatidic acid (PA) is interactive with G(alpha)q-linked agonists to stimulate GPCR signaling via phospholipase C-beta(1) (PLC-beta(1)). Phorbol 12-myristate 13-acetate (PMA) increases cellular levels of PA and phospholipase D activity (PLD). This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::784f0e07f26995ecb66d0341c9319aff
https://doi.org/10.1016/j.bbrc.2009.10.013
https://doi.org/10.1016/j.bbrc.2009.10.013
Publikováno v:
Cellular Signalling. 21:1379-1384
Phosphatidic acid (PA), generated downstream of monomeric Rho GTPases via phospholipase D (PLD) and additionally by diacylglycerol kinases (DGK), both stimulates phospholipase C-beta(1) (PLC-beta(1)) and potentiates stimulation of PLC-beta(1) activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a846ed675b38f6f3e28db6d8a46a61
https://doi.org/10.1016/j.cellsig.2009.04.005
https://doi.org/10.1016/j.cellsig.2009.04.005
Autor:
Irene Litosch
Publikováno v:
Life sciences. 137
The phosphatidylinositol-specific phospholipase C (PLC) family is known to regulate physiological response through an increase in the levels of cytosolic Ca(2+). PLC hydrolyzes phosphatidylinositol-4, 5-bisphosphate (PIP2) to inositol-1, 4, 5-trispho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adedaa6697846e481923efa115d2391a
https://pubmed.ncbi.nlm.nih.gov/26239437
https://pubmed.ncbi.nlm.nih.gov/26239437
Autor:
Irene Litosch
Publikováno v:
Biochemistry. 42:1618-1623
Phosphatidic acid (PA) stimulates phospholipase C-beta(1) (PLC-beta(1)) activity and promotes G protein stimulation of PLC-beta(1) activity. The isoform dependence for PA regulation of PLC-beta activity as well as the role of PA in modulating regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021617559d1ddd6f3506c4be4c97a17c
https://doi.org/10.1021/bi026414h
https://doi.org/10.1021/bi026414h
Autor:
Irene Litosch
Publikováno v:
IUBMB Life (International Union of Biochemistry and Molecular Biology: Life). 54:253-260
The receptor-regulated phospholipase C-beta (PLC-beta) signaling pathway is an important component in a network of signaling cascades that regulate cell function. PLC-beta signaling has been implicated in the regulation of cardiovascular function and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ee7525b0e8f27db48a4f2622e300ea5
https://doi.org/10.1080/15216540215673
https://doi.org/10.1080/15216540215673
Autor:
Irene Litosch
Publikováno v:
Biochemistry. 39:7736-7743
The role of phosphatidic acid (PA) in regulating phospholipase C-beta(1) (PLC-beta(1)) activity was determined. PA promoted the binding of PLC-beta(1) to sucrose-loaded unilamellar vesicles (SLUV) containing phosphatidylcholine. PA increased enzymati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce4bcb00a2adc1c01da04204ccbb804
https://doi.org/10.1021/bi000022y
https://doi.org/10.1021/bi000022y