Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Irene Ligielli"'
Autor:
Harry Ridgway, Graham J. Moore, Thomas Mavromoustakos, Sotirios Tsiodras, Irene Ligielli, Konstantinos Kelaidonis, Christos T. Chasapis, Laura Kate Gadanec, Anthony Zulli, Vasso Apostolopoulos, Russell Petty, Ioannis Karakasiliotis, Vassilis G. Gorgoulis, John M. Matsoukas
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 2091-2111 (2022)
The discovery and facile synthesis of a new class of sartan-like arterial antihypertensive drugs (angiotensin receptor blockers [ARBs]), subsequently referred to as “bisartans” is reported. In vivo results and complementary molecular modelling pr
Externí odkaz:
https://doaj.org/article/c273711c046740748e8c42638b922ec3
Autor:
Konstantinos Kelaidonis, Irene Ligielli, Spiros Letsios, Veroniki P. Vidali, Thomas Mavromoustakos, Niki Vassilaki, Graham J. Moore, Weronika Hoffmann, Katarzyna Węgrzyn, Harry Ridgway, Christos T. Chasapis, John M. Matsoukas
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 8454 (2023)
This study is an extension of current research into a novel class of synthetic antihypertensive drugs referred to as “bisartans”, which are bis-alkylated imidazole derivatives bearing two symmetric anionic biphenyltetrazoles. Research to date ind
Externí odkaz:
https://doaj.org/article/6ff9a296f8db4d05bd42dce022ee6816
Autor:
John M. Matsoukas, Laura Kate Gadanec, Anthony Zulli, Vasso Apostolopoulos, Konstantinos Kelaidonis, Irene Ligielli, Kalliopi Moschovou, Nikitas Georgiou, Panagiotis Plotas, Christos T. Chasapis, Graham Moore, Harry Ridgway, Thomas Mavromoustakos
Publikováno v:
Biomedicines, Vol 10, Iss 7, p 1731 (2022)
Diminazene aceturate (DIZE) is a putative angiotensin-converting enzyme 2 (ACE2) activator and angiotensin type 1 receptor antagonist (AT1R). Its simple chemical structure possesses a negatively charged triazene segment that is homologous to the tetr
Externí odkaz:
https://doaj.org/article/7b5d7773b68e4ceaa0b69e34701d9cbb
Autor:
Graham J. Moore, Harry Ridgway, Konstantinos Kelaidonis, Christos T. Chasapis, Irene Ligielli, Thomas Mavromoustakos, Joanna Bojarska, John M. Matsoukas
Publikováno v:
Molecules, Vol 27, Iss 15, p 4854 (2022)
Angiotensin receptor blockers (ARBs) used in the treatment of hypertension and potentially in SARS-CoV-2 infection exhibit inverse agonist effects at angiotensin AR1 receptors, suggesting the receptor may have evolved to accommodate naturally occurri
Externí odkaz:
https://doaj.org/article/16c7f511d66a4c7f8ef39a135dff15e8
Autor:
Harry Ridgway, Christos T. Chasapis, Konstantinos Kelaidonis, Irene Ligielli, Graham J. Moore, Laura Kate Gadanec, Anthony Zulli, Vasso Apostolopoulos, Thomas Mavromoustakos, John M. Matsoukas
Publikováno v:
Viruses, Vol 14, Iss 5, p 1029 (2022)
SARS-CoV-2 is a global challenge due to its ability to mutate into variants that spread more rapidly than the wild-type virus. Because the molecular biology of this virus has been studied in such great detail, it represents an archetypal paradigm for
Externí odkaz:
https://doaj.org/article/693ec5b86d2b4c4ca9682b1260b5d669
Autor:
John M. Matsoukas, Irene Ligielli, Christos T. Chasapis, Konstantinos Kelaidonis, Vasso Apostolopoulos, Thomas Mavromoustakos
Publikováno v:
Brain Sciences, Vol 11, Iss 12, p 1583 (2021)
Multiple Sclerosis (MS) is a serious autoimmune disease. The patient in an advanced state of the disease has restrained mobility and remains handicapped. It is therefore understandable that there is a great need for novel drugs and vaccines for the t
Externí odkaz:
https://doaj.org/article/b542a614566045e796f3e6a38bac1d46
Autor:
Thomas Mavromoustakos, Christos T. Chasapis, Vasso Apostolopoulos, John Matsoukas, Irene Ligielli, Konstantinos Kelaidonis
Publikováno v:
Brain Sciences, Vol 11, Iss 1583, p 1583 (2021)
Brain Sciences
Brain Sciences
Multiple Sclerosis (MS) is a serious autoimmune disease. The patient in an advanced state of the disease has restrained mobility and remains handicapped. It is therefore understandable that there is a great need for novel drugs and vaccines for the t