Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Irene H. Cheng"'
Publikováno v:
Journal of Functional Foods, Vol 16, Iss , Pp 378-385 (2015)
Alzheimer's disease (AD) is characterized by progressive formation of β-amyloid peptide (Aβ) in the brain. Aβ induced oxidative stress may cause cis-trans isomerization of fatty acids. However, the research on AD rarely discusses the correlation b
Externí odkaz:
https://doaj.org/article/d18e0f75bb7d4c78a9ca208f1454c0c0
Publikováno v:
IUBMB lifeREFERENCES. 74(8)
Alzheimer's disease (AD) is a neurodegenerative disease that impairs multiple memory domains without an effective prevention or treatment approach. Amyloid plaque-induced neuroinflammation exacerbates neurodegeneration and cognitive impairment in AD.
Autor:
Ting Bin Chen, Szu Ying Lin, Yi Jung Lee, Pei Ning Wang, Chaur Jong Hu, Irene H. Cheng, Jun Peng Chen
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports
Levels of amyloid-β (Aβ) and tau peptides in brain have been associated with Alzheimer disease (AD). The current study investigated the abilities of plasma Aβ42 and total-tau (t-tau) levels in predicting cognitive decline in subjects with amnestic
Autor:
Irene H. Cheng, Po Chen Lin, Yi Jung Lee, Yu Hua Lai, Ting Ling Ke, Ting Bin Chen, Pei Ning Wang, Jun Peng Chen, Szu Ying Lin
Publikováno v:
Dementia and Geriatric Cognitive Disorders. 48:180-195
Background: Changes in cerebrospinal fluid, neuroimaging, and cognitive functions have been used as diagnostic biomarkers of Alzheimer’s disease (AD). This study aimed to investigate the temporal trajectories of plasma biomarkers in subjects with m
Autor:
Guan Chiun Lee, Li Chen Kuo, Chien An Yao, Yan Qing Song, Wen-Chin Yang, Yenshou Lin, Chiang Ting Chien, Irene H. Cheng
Publikováno v:
Journal of Agricultural and Food Chemistry. 67:81-89
Utilizing the N-methyl-d-aspartate (NMDA) receptor antagonist as a strategy, memantine is the only agent available for clinically treating mild to severe Alzheimer's disease (AD). Our aim was to develop novel similar herb-based drugs. Using a screeni
Autor:
Wei-Ting Chen, Chen-Jee Hong, Ya-Tzu Lin, Wen-Han Chang, He-Ting Huang, Jhih-Ying Liao, Yu-Jen Chang, Yi-Fang Hsieh, Chih-Ya Cheng, Hsiu-Chih Liu, Yun-Ru Chen, Irene H Cheng
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35807 (2012)
Amyloid precursor protein (APP) mutations associated with familial Alzheimer's disease (AD) usually lead to increases in amyloid β-protein (Aβ) levels or aggregation. Here, we identified a novel APP mutation, located within the Aβ sequence (Aβ(D7
Externí odkaz:
https://doaj.org/article/fcccf07e3bce463398e71a18fc96c906
Autor:
Ru-Yin Chen, Chao-Lin Chang, Yu-Yi Lin, Irene H. Cheng, Chia-Chu Wu, Yi-Heng Tai, Kai-Chen Wang
Publikováno v:
Oncotarget
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder and is triggered via abnormal accumulation of amyloid-β peptide (Aβ). Aggregated Aβ is responsible for disrupting calcium homeostasis, inducing neuroinflammation, and promot
Autor:
Chen-Jee Hong, Pei-Jane Tsai, Chih-Ya Cheng, Chuan-Kai Chou, Huei-Fen Jheng, You-Chung Chuang, Chia-Ning Yang, Ya-Tzu Lin, Chih-Wei Hsu, Irene H Cheng, Shiow-Yi Chen, Shih-Jen Tsai, Ying-Jay Liou, Yau-Sheng Tsai
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15333 (2010)
BACKGROUND: Obesity is a multifactorial disease that arises from complex interactions between genetic predisposition and environmental factors. Leptin is central to the regulation of energy metabolism and control of body weight in mammals. METHODOLOG
Externí odkaz:
https://doaj.org/article/98b02cf4459d46edaf42dff56f4291d7
Publikováno v:
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-17 (2017)
Molecular Neurodegeneration
Molecular Neurodegeneration
Background Microglia mediate amyloid-beta peptide (Aβ)-induced neuroinflammation, which is one of the key events in the pathogenesis of Alzheimer’s disease (AD). Decoy receptor 3 (DcR3)/TNFRSF6B is a pleiotropic immunomodulator that promotes macro
Publikováno v:
Journal of Functional Foods, Vol 16, Iss, Pp 378-385 (2015)
Alzheimer's disease (AD) is characterized by progressive formation of β-amyloid peptide (Aβ) in the brain. Aβ induced oxidative stress may cause cis-trans isomerization of fatty acids. However, the research on AD rarely discusses the correlation b