Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Irene Gutiérrez-Rojas"'
Autor:
Irene Gutiérrez-Rojas, Juan A. Ardura, Arancha R. Gortazar, Verónica Alonso, Luis Álvarez-Carrión, Peter A. Friedman
Publikováno v:
Endocrine-Related Cancer. 27:441-456
Bone metastases are common in advanced prostate cancer patients, but mechanisms by which specific pro-metastatic skeletal niches are formed before tumor cell homing are unclear. We aimed to analyze the effects of proteins secreted by primary prostate
Autor:
Irene Gutiérrez-Rojas, M Rosario Rodríguez-Ramos, Juan A. Ardura, Jose M. Pozuelo, Verónica Alonso, Luis Álvarez-Carrión
Publikováno v:
Carcinogenesis. 40:828-839
Advanced prostate cancer cells preferentially metastasize to bone by acquiring a bone phenotype that allows metastatic cells to thrive in the skeletal environment. Identification of factors that promote the expression of ectopic bone genes—process
Autor:
Irene Gutiérrez-Rojas, Verónica Alonso, Luis Álvarez-Carrión, María Rosario Rodríguez-Ramos, Juan A. Ardura
Publikováno v:
Cancers
Volume 13
Issue 3
Cancers, Vol 13, Iss 436, p 436 (2021)
Volume 13
Issue 3
Cancers, Vol 13, Iss 436, p 436 (2021)
Simple Summary Prostate cancer is one of the leading causes of death among men worldwide. Advanced prostate cancer is an incurable disease whose mechanisms of action are still not fully understood. Secretion of the matrix protein MINDIN has been asso
Publikováno v:
Cancers, Vol 12, Iss 1071, p 1071 (2020)
Cancers
Cancers
Advanced prostate cancers that progress to tumor metastases are often considered incurable or difficult to treat. The etiology of prostate cancers is multi-factorial. Among other factors, de-regulation of calcium signals in prostate tumor cells media
Autor:
Johannes P.T.M. van Leeuwen, Sergio Portal-Núñez, Oskarina Hernández Bolívar, Pedro Esbrit, Bram C. J. van der Eerden, Irene Gutiérrez-Rojas, Daniel Lozano, Juan A. Ardura, Mónica De la Fuente, Ana López-Herradón, Marijke Schreuders-Koedam, Alexander M Proctor, Francisca Mulero, María José Alcaraz
Publikováno v:
Journals of Gerontology Series A-Biological Sciences and Medical Sciences, 71(3), 290-299. Oxford University Press
In the present study, the possibility that a diabetic (DM) status might worsen age-related bone deterioration was explored in mice. Male CD-1 mice aged 2 (young control group) or 16 months, nondiabetic or made diabetic by streptozotocin injections, w
Autor:
Anna Novials, P. Moreno, Alicia Acitores, Daniel Lozano, A. Rovira, María L. Villanueva-Peñacarrillo, Irene Gutiérrez-Rojas, I. Ramos-Álvarez, B Nuche-Berenguer, E. Martín-Crespo, Pedro Esbrit
Publikováno v:
Molecular and Cellular Endocrinology. 365:309-315
Amylin displays osteogenic features, but its role in diabetic osteopenia is unclear. We examined the possible osteogenic action of amylin infusion for 3days into fructose-induced insulin-resistant (IR) and streptozotocin-induced type 2 diabetic (T2D)
Autor:
Juan A, Ardura, Sergio, Portal-Núñez, Daniel, Lozano, Irene, Gutiérrez-Rojas, Sandra, Sánchez-Salcedo, Ana, López-Herradón, Francisca, Mulero, María L, Villanueva-Peñacarrillo, María, Vallet-Regí, Pedro, Esbrit
Publikováno v:
Journal of biomedical materials research. Part A. 104(8)
Diabetes mellitus (DM) and aging are associated with bone fragility and increased fracture risk. Both (1-37) N- and (107-111) C-terminal parathyroid hormone-related protein (PTHrP) exhibit osteogenic properties. We here aimed to evaluate and compare
Autor:
Veronica Sancho, Isabel Valverde, Paola Moreno, Alicia Acitores, María Luisa Villanueva-Peñacarrillo, Bernardo Nuche-Berenguer, Nieves González, Irene Gutiérrez-Rojas
Publikováno v:
Journal of Molecular Endocrinology. 48:37-47
Exendin-4 (Ex-4) mimics glucagon-like peptide-1 (GLP-1 or GCG as listed in the HUGO database), being anti-diabetic and anorectic, in stimulating glucose and lipid metabolism in extrapancreatic tissues. We studied the characteristics of Ex-4 and GLP-1
Autor:
Montse Visa, Irene Gutiérrez-Rojas, Willy Malaisse, Anna Novials, Alicia Acitores, Leocadio Rodríguez-Mañas, P. Moreno, Nieves González, Ramon Gomis, Isabel Valverde, Bernardo Nuche-Berenguer, M El Assar, María Luisa Villanueva-Peñacarrillo
Publikováno v:
Peptides. 32:2077-2085
Amylin is co-secreted with insulin, responds to the same stimuli, is anorectic, lowers body weight by reducing fat mass, and is proposed for diabetes treatment. We examined the effect of a 3-day constant infusion of close to physiological doses of am
Autor:
Daniel Lozano, María L. Mariñoso, Paola Moreno, Pedro Esbrit, María Luisa Villanueva-Peñacarrillo, Bernardo Nuche-Berenguer, Irene Gutiérrez-Rojas
Publikováno v:
Journal of Endocrinology. 209:203-210
Increased fat mass contributes to bone deterioration. Glucagon-like peptide 1 (GLP-1) and its related peptide exendin 1–39 amide (Ex-4), two lipid-lowering peptides, exert osteogenic effects in diabetic states. We examined the actions of 3-day admi