Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Irene Gonzalez-Menendez"'
Autor:
Marilena Poxleitner, Sabrina H. L. Hoffmann, Georgy Berezhnoy, Tudor M. Ionescu, Irene Gonzalez-Menendez, Florian C. Maier, Dominik Seyfried, Walter Ehrlichmann, Leticia Quintanilla-Martinez, Andreas M. Schmid, Gerald Reischl, Christoph Trautwein, Andreas Maurer, Bernd J. Pichler, Kristina Herfert, Nicolas Beziere
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-29 (2024)
Abstract Diet-induced increase in body weight is a growing health concern worldwide. Often accompanied by a low-grade metabolic inflammation that changes systemic functions, diet-induced alterations may contribute to neurodegenerative disorder progre
Externí odkaz:
https://doaj.org/article/67e4f3a5099d4da3aa33f787295c7a78
Autor:
Ali El‐Ayoubi, Arsen Arakelyan, Moritz Klawitter, Luisa Merk, Siras Hakobyan, Irene Gonzalez‐Menendez, Leticia Quintanilla Fend, Per Sonne Holm, Wolfgang Mikulits, Matthias Schwab, Lusine Danielyan, Ulrike Naumann
Publikováno v:
Molecular Oncology, Vol 18, Iss 3, Pp 528-546 (2024)
Neural stem cells (NSCs) are considered to be valuable candidates for delivering a variety of anti‐cancer agents, including oncolytic viruses, to brain tumors. However, owing to the previously reported tumorigenic potential of NSC cell lines after
Externí odkaz:
https://doaj.org/article/dcaccfb7170a43d7ba680bd39fee16e9
Autor:
Philipp Knopf, Dimitri Stowbur, Sabrina H. L. Hoffmann, Natalie Hermann, Andreas Maurer, Valentina Bucher, Marilena Poxleitner, Bredi Tako, Dominik Sonanini, Balaji Krishnamachary, Sanhita Sinharay, Birgit Fehrenbacher, Irene Gonzalez-Menendez, Felix Reckmann, David Bomze, Lukas Flatz, Daniela Kramer, Martin Schaller, Stephan Forchhammer, Zaver M. Bhujwalla, Leticia Quintanilla-Martinez, Klaus Schulze-Osthoff, Mark D. Pagel, Marieke F. Fransen, Martin Röcken, André F. Martins, Bernd J. Pichler, Kamran Ghoreschi, Manfred Kneilling
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-18 (2023)
Abstract Immune checkpoint inhibitors have revolutionized cancer therapy, yet the efficacy of these treatments is often limited by the heterogeneous and hypoxic tumor microenvironment (TME) of solid tumors. In the TME, programmed death-ligand 1 (PD-L
Externí odkaz:
https://doaj.org/article/b3fa661fa2c8409a83b991ccda94efe7
Autor:
Nicolai Stransky, Katrin Ganser, Leticia Quintanilla-Martinez, Irene Gonzalez-Menendez, Ulrike Naumann, Franziska Eckert, Pierre Koch, Stephan M. Huber, Peter Ruth
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract The intermediate-conductance calcium-activated potassium channel KCa3.1 has been proposed to be a new potential target for glioblastoma treatment. This study analyzed the effect of combined irradiation and KCa3.1-targeting with TRAM-34 in th
Externí odkaz:
https://doaj.org/article/0dbdaeb29d4f406cafec13f476947a99
Autor:
Selin Guergan, Bettina Boeer, Regina Fugunt, Gisela Helms, Carmen Roehm, Anna Solomianik, Alexander Neugebauer, Daniela Nuessle, Mirjam Schuermann, Kristin Brunecker, Ovidiu Jurjut, Karen A. Boehme, Sascha Dammeier, Markus D. Enderle, Sabrina Bettio, Irene Gonzalez-Menendez, Annette Staebler, Sara Y. Brucker, Bernhard Kraemer, Diethelm Wallwiener, Falko Fend, Markus Hahn
Publikováno v:
Diagnostics, Vol 14, Iss 3, p 338 (2024)
Breast conserving resection with free margins is the gold standard treatment for early breast cancer recommended by guidelines worldwide. Therefore, reliable discrimination between normal and malignant tissue at the resection margins is essential. In
Externí odkaz:
https://doaj.org/article/67d382e6de984874b27c584118bc7429
Autor:
Laimdota Zizmare, Roman Mehling, Irene Gonzalez-Menendez, Caterina Lonati, Leticia Quintanilla-Martinez, Bernd J. Pichler, Manfred Kneilling, Christoph Trautwein
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Nuclear magnetic resonance spectroscopy-based tissue metabolomics is used to define detailed temporal signatures of acute and chronic inflammation in cutaneous delayed-type hypersensitivity reaction.
Externí odkaz:
https://doaj.org/article/1e64b6a045ba453a9c984dad1ad77bf1
Autor:
Sophie Henneberg, Anja Hasenberg, Andreas Maurer, Franziska Neumann, Lea Bornemann, Irene Gonzalez-Menendez, Andreas Kraus, Mike Hasenberg, Christopher R. Thornton, Bernd J. Pichler, Matthias Gunzer, Nicolas Beziere
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Invasive pulmonary aspergillosis is a life-threatening fungal lung disease devoid of specific rapid diagnosis and with limited therapeutic options. Here, the authors show how state-of-the-art imaging approaches can enable specific diagnosis and thera
Externí odkaz:
https://doaj.org/article/c368bc0bd6144b6f8b5657fa52156a38
Autor:
Bernhard N. Bohnert, Irene Gonzalez-Menendez, Thomas Dörffel, Jonas C. Schneider, Mengyun Xiao, Andrea Janessa, M. Zaher Kalo, Birgit Fehrenbacher, Martin Schaller, Nicolas Casadei, Kerstin Amann, Christoph Daniel, Andreas L. Birkenfeld, Florian Grahammer, Lahoucine Izem, Edward F. Plow, Leticia Quintanilla-Martinez, Ferruh Artunc
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 9 (2021)
Susceptibility to doxorubicin-induced nephropathy (DIN), a toxic model for the induction of proteinuria in mice, is related to the single-nucleotide polymorphism (SNP) C6418T of the Prkdc gene encoding for the DNA-repair enzyme DNA-PKcs. In addition,
Externí odkaz:
https://doaj.org/article/f61afe8bfcdd4d3ca25f47e7366b3a1a
Autor:
Andrea Forschner, Franz-Joachim Hilke, Irina Bonzheim, Axel Gschwind, German Demidov, Teresa Amaral, Stephan Ossowski, Olaf Riess, Christopher Schroeder, Peter Martus, Bernhard Klumpp, Irene Gonzalez-Menendez, Claus Garbe, Heike Niessner, Tobias Sinnberg
Publikováno v:
Cancers, Vol 12, Iss 3, p 540 (2020)
Background: Mucosal and acral melanoma respond worse to immune checkpoint inhibitors (ICI) than cutaneous melanoma. MDM2/4 as well as EGFR amplifications are supposed to be associated with hyperprogression on ICI in diverse cancers. We therefore inve
Externí odkaz:
https://doaj.org/article/5335b47105df473795f5281f481e68e5
Autor:
Andrew Muranyi, Tobias Ammer, Anna Kechter, Vijay P. S. Rawat, Amit Sinha, Irene Gonzalez-Menendez, Leticia Quintanilla-Martinez, Anca Azoitei, Cagatay Günes, Annalisa Mupo, George Vassiliou, Shiva Bamezai, Christian Buske
Publikováno v:
Blood Advances. 7:351-364
NPM1 is among the most frequently mutated genes in acute myeloid leukemia (AML). Mutations in the NPM1 gene result in the increased export of NPM1 to the cytoplasm (NPM1c) and are associated with multiple transforming events including the aberrant up