Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Irene E. Whitney"'
Publikováno v:
eLife, Vol 11 (2022)
The genesis of broad neuronal classes from multipotential neural progenitor cells has been extensively studied, but less is known about the diversification of a single neuronal class into multiple types. We used single-cell RNA-seq to study how newly
Externí odkaz:
https://doaj.org/article/a10efda4c53b4e888c1b7ce1e26c7c78
Autor:
Amanda G. Kautzman, Patrick W. Keeley, Caroline R. Ackley, Stephanie Leong, Irene E. Whitney, Benjamin E. Reese
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
The present study interrogated a quantitative trait locus (QTL) on Chr 4 associated with the population sizes of two types of bipolar cell in the mouse retina. This locus was identified by quantifying the number of rod bipolar cells and Type 2 cone b
Externí odkaz:
https://doaj.org/article/ae0ed00fe46a4202a17bd37f98a71eb8
Autor:
Inbal Benhar, Jiarui Ding, Wenjun Yan, Irene E. Whitney, Anne Jacobi, Malika Sud, Grace Burgin, Karthik Shekhar, Nicholas M. Tran, Chen Wang, Zhigang He, Joshua R. Sanes, Aviv Regev
Publikováno v:
Nature immunology, vol 24, iss 4
Non-neuronal cells are key to the complex cellular interplay that follows central nervous system insult. To understand this interplay, we generated a single-cell atlas of immune, glial and retinal pigment epithelial cells from adult mouse retina befo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8a25e32c4f97c601714b4199c9b577
https://escholarship.org/uc/item/9zj7f36w
https://escholarship.org/uc/item/9zj7f36w
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Transgenic mouse lines are routinely employed to label and manipulate distinct cell types. The transgene generally comprises cell-type specific regulatory elements linked to a cDNA encoding a reporter or other protein. However, off-target expression
Externí odkaz:
https://doaj.org/article/275fb17b356b4c4e99e1244bdd85aaa6
Autor:
Irene E. Whitney, Salwan Butrus, Michael A. Dyer, Fred Rieke, Joshua R. Sanes, Karthik Shekhar
The development and connectivity of retinal ganglion cells (RGCs), the retina’s sole output neurons, are patterned by activity-independent transcriptional programs and activity-dependent remodeling. To inventory the molecular correlates of these in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61eefb6beb0abb424df6d51f49b8c14
https://doi.org/10.1101/2022.04.20.488897
https://doi.org/10.1101/2022.04.20.488897
Autor:
Joshua R. Sanes, Wenjun Yan, Mallory A. Laboulaye, Irene E. Whitney, Nicholas M. Tran, Inbal Benhar
Publikováno v:
J Neurosci
Amacrine cells (ACs) are a diverse class of interneurons that modulate input from photoreceptors to retinal ganglion cells (RGCs), rendering each RGC type selectively sensitive to particular visual features, which are then relayed to the brain. While
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c430b644f5439ebcbb48f06af1bd8f9
https://doi.org/10.1523/jneurosci.0471-20.2020
https://doi.org/10.1523/jneurosci.0471-20.2020
The genesis of broad neuronal classes from multipotential neural progenitor cells has been extensively studied, but less is known about the diversification of a single neuronal class into multiple types. We used single-cell RNA-seq to study how newly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fee32296a330fc9be9d108b2fbbd083
https://doi.org/10.1101/2021.10.21.465277
https://doi.org/10.1101/2021.10.21.465277
Publikováno v:
The Journal of Immunology. 208:172.09-172.09
Biological resolution at the level of individual cells is powering the next phase of precision health. Honeycomb Biotechnologies currently offers an assay for single-cell RNA sequencing with the HIVE™ scRNAseq Solution. The HIVE is a portable, hand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7dcfbbb2fa4ac049b92b58b092179b2
https://doi.org/10.4049/jimmunol.208.supp.172.09
https://doi.org/10.4049/jimmunol.208.supp.172.09
Autor:
Anne Jacobi, McKinzie E. Arnold, Wenjun Yan, Zhigang He, Dingchang Lin, Aviv Regev, Charles M. Lieber, Guosong Hong, Chen Wang, Inbal Benhar, Karthik Shekhar, Joshua Z. Levin, Joshua R. Sanes, Nicholas M. Tran, Irene E. Whitney, Jung Min Lee, Xian Adiconis
Publikováno v:
Neuron
PMC
PMC
© 2019 Elsevier Inc. Neuronal types in the central nervous system differ dramatically in their resilience to injury or other insults. Here we studied the selective resilience of mouse retinal ganglion cells (RGCs) following optic nerve crush (ONC),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8e665c332d41207d58b1a9de85c65c
https://doi.org/10.1038/s41583-019-0259-5
https://doi.org/10.1038/s41583-019-0259-5