Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Irene Cherni"'
Autor:
Rebecca F. Halperin, John D. Carpten, Zarko Manojlovic, Jessica Aldrich, Jonathan Keats, Sara Byron, Winnie S. Liang, Megan Russell, Daniel Enriquez, Ana Claasen, Irene Cherni, Baffour Awuah, Joseph Oppong, Max S. Wicha, Lisa A. Newman, Evelyn Jaigge, Seungchan Kim, David W. Craig
Publikováno v:
BMC Medical Genomics, Vol 10, Iss 1, Pp 1-17 (2017)
Abstract Background Significant clinical and research applications are driving large scale adoption of individualized tumor sequencing in cancer in order to identify tumors-specific mutations. When a matched germline sample is available, somatic muta
Externí odkaz:
https://doaj.org/article/fde1123b7aa84a3eadeb4956afa4c35d
Autor:
Mitesh J. Borad, Jan B. Egan, Rachel M. Condjella, Winnie S. Liang, Rafael Fonseca, Nicole R. Ritacca, Ann E. McCullough, Michael T. Barrett, Katherine S. Hunt, Mia D. Champion, Maitray D. Patel, Scott W. Young, Alvin C. Silva, Thai H. Ho, Thorvardur R. Halfdanarson, Robert R. McWilliams, Konstantinos N. Lazaridis, Ramesh K. Ramanathan, Angela Baker, Jessica Aldrich, Ahmet Kurdoglu, Tyler Izatt, Alexis Christoforides, Irene Cherni, Sara Nasser, Rebecca Reiman, Lori Cuyugan, Jacquelyn McDonald, Jonathan Adkins, Stephen D. Mastrian, Riccardo Valdez, Dawn E. Jaroszewski, Daniel D. Von Hoff, David W. Craig, A. Keith Stewart, John D. Carpten, Alan H. Bryce
Publikováno v:
Scientific Reports, Vol 6, Iss 1, Pp 1-12 (2016)
Abstract DNA focused panel sequencing has been rapidly adopted to assess therapeutic targets in advanced/refractory cancer. Integrated Genomic Profiling (IGP) utilising DNA/RNA with tumour/normal comparisons in a Clinical Laboratory Improvement Amend
Externí odkaz:
https://doaj.org/article/0d55a397502a4dbe956a6fd30cff0c29
Autor:
Ho-Hsien Lee, Irene Cherni, HongQi Yu, Raimund Fromme, Jeffrey D. Doran, Ingo Grotjohann, Michele Mittman, Shibom Basu, Arpan Deb, Katerina Dörner, Andrew Aquila, Anton Barty, Sébastien Boutet, Henry N. Chapman, R. Bruce Doak, Mark S. Hunter, Daniel James, Richard A. Kirian, Christopher Kupitz, Robert M. Lawrence, Haiguang Liu, Karol Nass, Ilme Schlichting, Kevin E. Schmidt, M. Marvin Seibert, Robert L. Shoeman, John C. H. Spence, Francesco Stellato, Uwe Weierstall, Garth J. Williams, Chunhong Yoon, Dingjie Wang, Nadia A. Zatsepin, Brenda G. Hogue, Nobuyuki Matoba, Petra Fromme, Tsafrir S. Mor
Publikováno v:
IUCrJ, Vol 1, Iss 5, Pp 305-317 (2014)
CTB-MPR is a fusion protein between the B subunit of cholera toxin (CTB) and the membrane-proximal region of gp41 (MPR), the transmembrane envelope protein of Human immunodeficiency virus 1 (HIV-1), and has previously been shown to induce the product
Externí odkaz:
https://doaj.org/article/e93878e8686c49afaf11b3e9c588d63b
Autor:
Mitesh J Borad, Mia D Champion, Jan B Egan, Winnie S Liang, Rafael Fonseca, Alan H Bryce, Ann E McCullough, Michael T Barrett, Katherine Hunt, Maitray D Patel, Scott W Young, Joseph M Collins, Alvin C Silva, Rachel M Condjella, Matthew Block, Robert R McWilliams, Konstantinos N Lazaridis, Eric W Klee, Keith C Bible, Pamela Harris, Gavin R Oliver, Jaysheel D Bhavsar, Asha A Nair, Sumit Middha, Yan Asmann, Jean-Pierre Kocher, Kimberly Schahl, Benjamin R Kipp, Emily G Barr Fritcher, Angela Baker, Jessica Aldrich, Ahmet Kurdoglu, Tyler Izatt, Alexis Christoforides, Irene Cherni, Sara Nasser, Rebecca Reiman, Lori Phillips, Jackie McDonald, Jonathan Adkins, Stephen D Mastrian, Pamela Placek, Aprill T Watanabe, Janine Lobello, Haiyong Han, Daniel Von Hoff, David W Craig, A Keith Stewart, John D Carpten
Publikováno v:
PLoS Genetics, Vol 10, Iss 2, p e1004135 (2014)
Advanced cholangiocarcinoma continues to harbor a difficult prognosis and therapeutic options have been limited. During the course of a clinical trial of whole genomic sequencing seeking druggable targets, we examined six patients with advanced chola
Externí odkaz:
https://doaj.org/article/72d9a122f58441d9a86d9254c686cd3b
Autor:
Brendan D Looyenga, Danielle Hutchings, Irene Cherni, Chris Kingsley, Glen J Weiss, Jeffrey P Mackeigan
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30820 (2012)
Constitutive activation of STAT3 is a common feature in many solid tumors including non-small cell lung carcinoma (NSCLC). While activation of STAT3 is commonly achieved by somatic mutations to JAK2 in hematologic malignancies, similar mutations are
Externí odkaz:
https://doaj.org/article/77efa532dc6343d789f76b66d67c4171
Autor:
Glen J Weiss, Winnie S Liang, Tyler Izatt, Shilpi Arora, Irene Cherni, Robert N Raju, Galen Hostetter, Ahmet Kurdoglu, Alexis Christoforides, Shripad Sinari, Angela S Baker, Raghu Metpally, Waibhav D Tembe, Lori Phillips, Daniel D Von Hoff, David W Craig, John D Carpten
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37029 (2012)
Olfactory neuroblastoma (ONB) is a rare cancer of the sinonasal tract with little molecular characterization. We performed whole genome sequencing (WGS) on paired normal and tumor DNA from a patient with metastatic-ONB to identify the somatic alterat
Externí odkaz:
https://doaj.org/article/4e2340d80321458c9712eae24d4a2f0f
Autor:
Shilpi Arora, Ronald L Korn, Elizabeth Lenkiewicz, Irene Cherni, Thomas G Beach, Galen Hostetter, Michael T Barrett, Glen J Weiss
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45614 (2012)
Maxillary sinus carcinoma (MSC) is a rare cancer of the head and neck region. Patients are treated with surgery, radiation therapy, and chemotherapy and the treatment regimen is based on patient's age, general health condition, disease stage, and its
Externí odkaz:
https://doaj.org/article/6e181c5025a041f7bc078788224fcb3f
Autor:
Sungwon Jung, Seungchan Kim, Molly Gale, Irene Cherni, Rafael Fonseca, John Carpten, Bodour Salhia
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52626 (2012)
Previous studies have now demonstrated that both genic and global hypomethylation characterizes the multiple myeloma (MM) epigenome. Whether these methylation changes are associated with global and corresponding increases (or decreases) in transcript
Externí odkaz:
https://doaj.org/article/98ded139e2154d16a4147c80c4df7773
Autor:
Megan Russell, Evelyn Jaigge, Baffour Awuah, Zarko Manojlovic, Jonathan J Keats, Rebecca F. Halperin, Lisa A. Newman, John D. Carpten, David Craig, Irene Cherni, Sara A. Byron, Ana M. Claasen, Seungchan Kim, Jessica Aldrich, Joseph K. Oppong, Winnie S. Liang, Daniel Enriquez, Max S. Wicha
Publikováno v:
BMC Medical Genomics, Vol 10, Iss 1, Pp 1-17 (2017)
BMC Medical Genomics
BMC Medical Genomics
Background Significant clinical and research applications are driving large scale adoption of individualized tumor sequencing in cancer in order to identify tumors-specific mutations. When a matched germline sample is available, somatic mutations may
Autor:
Michele Mittman, Raimund Fromme, Garth J. Williams, Robert L. Shoeman, Ingo Grotjohann, Tsafrir S. Mor, M. Marvin Seibert, R. Bruce Doak, HongQi Yu, Dingjie Wang, Karol Nass, Richard A. Kirian, Nadia A. Zatsepin, Kevin Schmidt, Uwe Weierstall, Haiguang Liu, Ilme Schlichting, Nobuyuki Matoba, Christopher Kupitz, Mark S. Hunter, Sébastien Boutet, Katerina Dörner, Robert M. Lawrence, Chun Hong Yoon, Arpan Deb, Henry N. Chapman, Petra Fromme, Daniel James, Francesco Stellato, Ho-Hsien Lee, Andrew Aquila, Shibom Basu, Brenda G. Hogue, Jeffrey D. Doran, Irene Cherni, Anton Barty, John C. H. Spence
Publikováno v:
IUCrJ, Vol 1, Iss 5, Pp 305-317 (2014)
IUCrJ 1(5), 305-317 (2014). doi:10.1107/S2052252514014900
IUCrJ
IUCrJ 1(5), 305-317 (2014). doi:10.1107/S2052252514014900
IUCrJ
Femtosecond X-ray crystallography allows structural analysis of a difficult-to-crystallize fusion protein that is a potential component of a candidate HIV-1 subunit vaccine.
CTB-MPR is a fusion protein between the B subunit of cholera toxin (CTB
CTB-MPR is a fusion protein between the B subunit of cholera toxin (CTB