Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Irene Calvo-Asensio"'
Autor:
Fabian Klein, Clara Veiga-Villauriz, Anastasiya Börsch, Stefano Maio, Sam Palmer, Fatima Dhalla, Adam E. Handel, Saulius Zuklys, Irene Calvo-Asensio, Lucas Musette, Mary E. Deadman, Andrea J. White, Beth Lucas, Graham Anderson, Georg A. Holländer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The network of thymic stromal cells provides essential niches with unique molecular cues controlling T cell development and selection. Recent single-cell RNA sequencing studies have uncovered previously unappreciated transcriptional heteroge
Externí odkaz:
https://doaj.org/article/58106d4dcccf4fdebf3a90d5d836fcdb
Autor:
Jeanette Baran-Gale, Michael D Morgan, Stefano Maio, Fatima Dhalla, Irene Calvo-Asensio, Mary E Deadman, Adam E Handel, Ashley Maynard, Steven Chen, Foad Green, Rene V Sit, Norma F Neff, Spyros Darmanis, Weilun Tan, Andy P May, John C Marioni, Chris P Ponting, Georg A Holländer
Publikováno v:
eLife, Vol 9 (2020)
Ageing is characterised by cellular senescence, leading to imbalanced tissue maintenance, cell death and compromised organ function. This is first observed in the thymus, the primary lymphoid organ that generates and selects T cells. However, the mol
Externí odkaz:
https://doaj.org/article/0801b66fbced40e4a16cb9a6776b1379
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
For successful bone marrow transplantation (BMT), a preconditioning regime involving chemo and radiotherapy is used that results in DNA damage to both hematopoietic and stromal elements. Following radiation exposure, it is well recognized that a sing
Externí odkaz:
https://doaj.org/article/504d28c3ac32416d88bb5e0428980e71
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Mesenchymal stromal cells (MSCs) are multipotent progenitors supporting bone marrow hematopoiesis. MSCs have an efficient DNA damage response (DDR) and are consequently relatively radio-resistant cells. Therefore, MSCs are key to hematopoietic recons
Externí odkaz:
https://doaj.org/article/92f7c9fba74f4faa94d2cdfd060df0d3
Autor:
John Kenneth Eykelenboom, Emma Christina Harte, Lynn Canavan, Ana Pastor-Peidro, Irene Calvo-Asensio, Marta Llorens-Agost, Noel Francis Lowndes
Publikováno v:
Cell Reports, Vol 5, Iss 4, Pp 1095-1107 (2013)
Cells must accurately replicate and segregate their DNA once per cell cycle in order to successfully transmit genetic information. During S phase in the presence of agents that cause replication stress, ATR-dependent checkpoints regulate origin firin
Externí odkaz:
https://doaj.org/article/c24a8a79b3334c2188f6da805f084c88
Publikováno v:
The Scientific World Journal, Vol 2014 (2014)
Hybrids of Solanum melongena and S. aethiopicum are of interest as rootstocks of eggplant, as they are highly vigorous and can incorporate resistance to several diseases. However, hybridization between both species is difficult. Therefore, protocols
Externí odkaz:
https://doaj.org/article/a9302c32ac784cb2aeec9eb9072da8ea
Autor:
Norma F. Neff, Jeanette Baran-Gale, Ashley Maynard, Fatima Dhalla, Rene Sit, Chris P. Ponting, AP May, Weilun Tan, Steven Chen, Foad Green, Georg A. Holländer, Morgan, Adam E. Handel, Stefano Maio, John C. Marioni, Spyros Darmanis, Mary E. Deadman, Irene Calvo-Asensio
Publikováno v:
eLife
Baran-Gale, J, Morgan, M D, Maio, S, Dhalla, F, Calvo-Asensio, I, Deadman, M E, Handel, A E, Maynard, A, Chen, S, Green, F, Sit, R V, Neff, N F, Darmanis, S, Tan, W, May, A P, Marioni, J C, Ponting, C P & Holländer, G A 2020, ' Ageing compromises mouse thymus function and remodels epithelial cell differentiation ', eLIFE, vol. 9, no. 8, e56221 . https://doi.org/10.7554/eLife.56221
eLife, Vol 9 (2020)
eLife, 9
Baran-Gale, J, Morgan, M D, Maio, S, Dhalla, F, Calvo-Asensio, I, Deadman, M E, Handel, A E, Maynard, A, Chen, S, Green, F, Sit, R V, Neff, N F, Darmanis, S, Tan, W, May, A P, Marioni, J C, Ponting, C P & Holländer, G A 2020, ' Ageing compromises mouse thymus function and remodels epithelial cell differentiation ', eLIFE, vol. 9, no. 8, e56221 . https://doi.org/10.7554/eLife.56221
eLife, Vol 9 (2020)
eLife, 9
Ageing is characterised by cellular senescence, leading to imbalanced tissue maintenance, cell death and compromised organ function. This is first observed in the thymus, the primary lymphoid organ that generates and selects T cells. However, the mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8fc8a5ee53b84a3b59dd1f67e8e1170
Autor:
Mary E. Deadman, Stefano Maio, Irene Calvo-Asensio, Michael D Morgan, Rene Sit, Ashley Maynard, Jeanette Baran-Gale, Georg A. Holländer, Foad Green, Chris P. Ponting, Andy P May, Spyros Darmanis, Fatima Dhalla, Adam E. Handel, John C. Marioni, Norma Neff, Steven Chen, Weilun Tan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::236b8e956ec9ca76520abca1824add7b
https://doi.org/10.7554/elife.56221.sa2
https://doi.org/10.7554/elife.56221.sa2
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology
Frontiers in Immunology
For successful bone marrow transplantation (BMT), a preconditioning regime involving chemo and radiotherapy is used that results in DNA damage to both hematopoietic and stromal elements. Following radiation exposure, it is well recognized that a sing
Differential response of mouse thymic epithelial cell types to ionizing radiation-induced dna damage
Publikováno v:
Frontiers in Immunology
Thymic epithelial cells (TECs) are the main components of the thymic stroma that support and control T-cell development. Preparative regimens using DNA-damaging agents, such as total body irradiation and/or chemotherapeutic drugs, that are necessary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad606ec82c902660ec4f2e3ee07599bf
http://hdl.handle.net/10379/10663
http://hdl.handle.net/10379/10663