Chronic administration of prebiotics and probiotics ameliorates pathophysiological hallmarks of Alzheimer’s disease in a APP/PS1 transgenic mouse model

Autor: Daniele Lana, Chiara Traini, Irene Bulli, Giorgia Sarti, Giada Magni, Selene Attorre, Maria Grazia Giovannini, Maria Giuliana Vannucchi

Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)

Introduction: The gut microbiota (MB), although one of the main producers of Aβ in the body, in physiological conditions contributes to the maintainance of a healthy brain. Dysbiosis, the dysbalance between Gram-negative and Gram-positive bacteria i

Externí odkaz: https://doaj.org/article/8f4a39b44907410bbcdf1c4350d5a43e

Protective Effect of Adenosine A2B Receptor Agonist, BAY60-6583, Against Transient Focal Brain Ischemia in Rat

Autor: Ilaria Dettori, Lisa Gaviano, Filippo Ugolini, Daniele Lana, Irene Bulli, Giada Magni, Francesca Rossi, Maria Grazia Giovannini, Felicita Pedata

Publikováno v: Frontiers in Pharmacology, Vol 11 (2021)

Cerebral ischemia is a multifactorial pathology characterized first by an acute injury, due to excitotoxicity, followed by a secondary brain injury that develops hours to days after ischemia. During ischemia, adenosine acts as an endogenous neuroprot

Externí odkaz: https://doaj.org/article/322b25e979994da1b703b91879125f57

Protective effects of carbonic anhydrase inhibition in brain ischaemia in vitro and in vivo models

Autor: Irene Fusco, Martina Venturini, Felicita Pedata, Lorenzo Di Cesare Mannelli, Lisa Gaviano, Anna Maria Pugliese, Claudiu T. Supuran, Irene Bulli, Federica Cherchi, Carla Ghelardini, Ilaria Dettori, Alessio Nocentini, Elisabetta Coppi

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 964-976 (2021)

Ischaemic stroke is a leading cause of death and disability. One of the major pathogenic mechanisms after ischaemia includes the switch to the glycolytic pathway, leading to tissue acidification. Carbonic anhydrase (CA) contributes to pH regulation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b16c961b3e115d43cb24aab3d9c6e84
https://doaj.org/article/b71f43961f06497bbcb2ac3275cfbddc

Protective Effect of Adenosine A2B Receptor Agonist, BAY60-6583, Against Transient Focal Brain Ischemia in Rat

Autor: Maria Grazia Giovannini, Giada Magni, Felicita Pedata, Francesca Rossi, Daniele Lana, Filippo Ugolini, Irene Bulli, Ilaria Dettori, Lisa Gaviano

Publikováno v: Frontiers in Pharmacology, Vol 11 (2021)
Neuropharmacology (2020).
info:cnr-pdr/source/autori:Ilaria Dettori; Lisa Gaviano; Filippo Ugolini; Daniele Lana; Irene Bulli; Giada Magni; Francesca Rossi; Maria Grazia Giovannini; Felicita Pedata/titolo:Protective effect of adenosine A2B receptor agonist, BAY60-6583, against transient focal brain ischemia in rat/doi:/rivista:Neuropharmacology/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume

Cerebral ischemia is a multifactorial pathology characterized first by an acute injury, due to excitotoxicity, followed by a secondary brain injury that develops hours to days after ischemia. During ischemia, adenosine acts as an endogenous neuroprot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd23bb902e9c8a107bfb43405470dfd
https://doi.org/10.3389/fphar.2020.588757

New Insight into the Role of Adenosine in Demyelination, Stroke and Neuropathic Pain

Autor: Martina Venturini, Anna Maria Pugliese, Ilaria Dettori, Irene Bulli, Felicita Pedata, Federica Cherchi, Elisabetta Coppi

Publikováno v: Frontiers in Pharmacology, Vol 11 (2021)
Frontiers in Pharmacology

Our group of research has a long-time experience in studying the role/s of adenosine P1 receptors in health and disease conditions of the central nervous system (CNS). The effects of adenosine were investigated in our laboratory by the use of in vitr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9265e85802872987ae54a9375e2c9f06
https://www.frontiersin.org/articles/10.3389/fphar.2020.625662/full