Výsledky vyhledávání - "Irene Beausoleil"

Generation of anti-Neu-glycolyl-ganglioside antibodies by immunization with an anti-idiotype monoclonal antibody: A self versus non-self-matter

Autor: Mabel Rodríguez, Ana María Hernández, Alejandro López-Requena, Irene Beausoleil, Ana María Vázquez, Rolando Pérez

Publikováno v: Immunobiology. 210:11-21

We have previously generated a murine anti-idiotype (Ab2) monoclonal antibody (mAb) to a murine Ab1 mAb, named P3, which selectively binds Neu-glycolyl (NeuGc)-sialic acid on several monosialo- and disialogangliosides, and also reacts with sulfatides

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::517fe71fa57824c129168e714f88899a
https://doi.org/10.1016/j.imbio.2005.02.002

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Monoclonal anti-EGFreceptor antibody (ior-R3) pharmacokinetic study in tumor bearing nude mice: Role of the receptor-mediated endocytosis on drug clearance

Autor: Jorge Duconge, J F Amador, A. Macías, J Matheu, I. Garcia, Irene Beausoleil, Rafael Fernández Castillo, E Fernández-Sánchez

Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics. 27:101-105

With the purpose of describing the MAb ior-R3's kinetic behavior in disease state, this paper is focused on the study of this response using a human cancer (lung carcinoma cell line, H125) bearing nude mice animal model. This MAb was administered by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5297a3fe20d5a66daff734c3812a6f90
https://doi.org/10.1007/bf03190423

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Monoclonal anti-epidermal growth factor receptor (ior EGF/r3) antibody pharmacokinetic studies on nude mice I: a radio-receptor analysis applied to drug serum quantification

Autor: Eduardo Fernández-Sánchez, I. Garcia, Rubén Castillo, A. Macías, Irene Beausoleil, Jorge Duconge

Publikováno v: Journal of Pharmacy and Pharmacology. 54:59-64

Due to its antagonistic properties upon ligand-epidermal growth factor receptor (EGFr) interaction, the monoclonal antibody anti-EGFr ior EGF/r3 is considered a potential therapeutic agent against several epithelium-derived tumours. This paper afford

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d7820672001bf21396a352fbcfc2a9c
https://doi.org/10.1211/0022357021771922

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Short-term intra-nasal erythropoietin administration with low sialic acid content is without toxicity or erythropoietic effects

Autor: Jose A. Sanchez, Yamile Vega, Isbel Guerra, Raisell López, Irene Beausoleil, Pedro Barzaga, Micaela Couret, Alicia Lagarto, Tatiana Gabilondo, Odalys Valdes, Viviana Bueno

Publikováno v: Current neurovascular research. 9(4)

The objective of this investigation was to assess the toxicological potential of nasal formulation of erythropoietin with low sialic acid content (Neuro EPO) after 28 days of intra-nasal dosing in rats besides to evaluate the immunogenicity and eryth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2788857bbb461f5b6218edafcd0dc45b
https://pubmed.ncbi.nlm.nih.gov/22962865

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Kinetics of monoclonal anti-epidermal growth factor receptor antibody (IOR EGF/r3)-induced apoptosis in human carcinoma bearing nude mice

Autor: Jorge, Ducongé, Nelson, Merino, Dalia, Alvarez, Irene, Beausoleil, Eduardo, Fernández-Sánchez, Leyanis, Rodríguez, Alastair D, Burt

Publikováno v: Puerto Rico health sciences journal. 27(1)

Apoptosis seems to play an important role in cancer immunotherapy outcome. We have studied the kinetic pattern of apoptosis induction in H125 human lung carcinoma xenografts after treatment with the monoclonal antibody (MAb) anti-epidermal growth fac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4c9bd6447206db5a999a3e7adaa22250
https://pubmed.ncbi.nlm.nih.gov/18450231

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T cells are crucial for the anti-metastatic effect of anti-epidermal growth factor receptor antibodies

Autor: Rolando Pérez, Belinda Sánchez, Irene Beausoleil, Daniel F. Alonso, Greta Garrido, Pablo Lorenzano, Luis E. Fernández

Publikováno v: Cancer immunology, immunotherapy : CII. 56(11)

Experimental evidences supporting the epidermal growth factor receptor (EGFR) as an important molecule for tumor metastasis had been accumulated. Currently, anti-EGFR monoclonal antibodies (mAbs) constitute a promising approach for the treatment of p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b0601936f8dcb79adeca6cc5a76833
https://pubmed.ncbi.nlm.nih.gov/17415565

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Integrated pharmacokinetic-pharmacodynamic modeling and allometric scaling for optimizing the dosage regimen of the monoclonal ior EGF/r3 antibody

Autor: Gloria Vecino, Irene Beausoleil, Daniel Esteban Pineda Alvarez, Rubén Castillo, Eduardo Fernández-Sánchez, Tania Crombet, Maria A. Bécquer, Carmen Valenzuela, Janet Matheu, Jorge Duconge, Katia Alonso

Publikováno v: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 21(2-3)

The multiple-dose strategy with the monoclonal ior EGF/r3 antibody, in xenograft bearing nude mice, was supported upon the basis of its integrated pharmacokinetic-pharmacodynamic relationship, according to both the temporal (K(e0)=0.0015+/-0.000035h(

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4b7b72614ea55bba170a582a9078026
https://pubmed.ncbi.nlm.nih.gov/14757498

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