Výsledky vyhledávání - "Irene B. Larripa"

Akademický článek

Elevated levels of damage-associated molecular patterns HMGB1 and S100A8/A9 coupled with toll-like receptor-triggered monocyte activation are associated with inflammation in patients with myelofibrosis

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Inflammation plays a pivotal role in the pathogenesis of primary and post-essential thrombocythemia or post-polycythemia vera myelofibrosis (MF) in close cooperation with the underlying molecular drivers. This inflammatory state is induced by a dynam

Externí odkaz: https://doaj.org/article/5df717c398dd4954b8dd7bab8a1b84c2

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Akademický článek

High cell-free DNA is associated with disease progression, inflammasome activation and elevated levels of inflammasome-related cytokine IL-18 in patients with myelofibrosis

Autor: Geraldine De Luca, Paola R. Lev, Maria F. Camacho, Nora P. Goette, Federico Sackmann, Miguel A. Castro Ríos, Beatriz Moiraghi, Veronica Cortes Guerrieri, Georgina Bendek, Emiliano Carricondo, Alicia Enrico, Veronica Vallejo, Ana Varela, Marina Khoury, Marina Gutierrez, Irene B. Larripa, Rosana F. Marta, Ana C. Glembotsky, Paula G. Heller

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Myelofibrosis (MF) is a clonal hematopoietic stem cell disorder classified among chronic myeloproliferative neoplasms, characterized by exacerbated myeloid and megakaryocytic proliferation and bone marrow fibrosis. It is induced by driver (JAK2/CALR/

Externí odkaz: https://doaj.org/article/5d6f229ff02c42ab976c494419308bc5

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Akademický článek

Gene polymorphism profiles of drug-metabolising enzymes GSTM1, GSTT1 and GSTP1 in an Argentinian population

Autor: Natalia Weich, Alejandro Roisman, Belén Cerliani, Hilda V. Aráoz, Lilien Chertkoff, Silvina M. Richard, Irma Slavutsky, Irene B. Larripa, Ariela F. Fundia

Publikováno v: Annals of Human Biology, Vol 44, Iss 4, Pp 379-383 (2017)

Background: Glutathione S-transferases (GSTs) are drug-metabolising enzymes involved in biotransformation of carcinogens, drugs, xenobiotics and oxygen free radicals. Polymorphisms of GST genes contribute to inter-individual and population variabilit

Externí odkaz: https://doaj.org/article/1efde67b4c8c4be5bfdf00c77e345304

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Akademický článek

Sixteen novel hemophilia A causative mutations in the first Argentinian series of severe molecular defects

Autor: Liliana C. Rossetti, Claudia Pamela Radic, Miguel Candela, Raúl Pérez Bianco, Miguel de Tezanos Pinto, Anne Goodeve, Irene B. Larripa, Carlos D. De Brasi

Publikováno v: Haematologica, Vol 92, Iss 6 (2007)

Hemophilia A (HA) is caused by heterogeneous mutations in the factor VIII gene (F8). This paper reports 16 novel small F8-mutations and rearrangements in a series of 80 Argentinian families with severe-HA. Using an updated scheme for F8-analysis, we

Externí odkaz: https://doaj.org/article/52936d26ad09443eaddf0690ec512ed0

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Expression dynamics of the immune mediators ARG1, TBET, CIITA, IL10 and TGFB1 in chronic myeloid leukaemia patients during the first year of imatinib therapy

Autor: María Jazmín Toloza, Yesica Bestach, Marco Lincango-Yupanki, Javier Bordone, Romina Mariano, Melissa Tarqui, Mariel Pérez, Pedro Negri Aranguren, Alicia Enrico, Irene B. Larripa, Carolina B. Belli

Publikováno v: Gene. 813

The use of tyrosine kinase inhibitors seems to restore the broadly compromised immune system described in chronic myeloid leukaemia (CML) patients at diagnosis leading to a re-activation of the effector-mediated immune surveillance. Here, we describe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5853404cf1fe87db8bada53355ebfdea
https://pubmed.ncbi.nlm.nih.gov/34902507

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Myelodysplastic syndromes in South America: a multinational study of 1080 patients

Autor: Carolina B, Belli, Ronald Feitosa, Pinheiro, Yesica, Bestach, Irene B, Larripa, Roberta Sandra, da Silva Tanizawa, Graciela, Alfonso, Jacqueline, Gonzalez, Mariana, Rosenhain, Nora, Watman, Marcela, Cavalcante de Andrade Silva, Pedro, Negri Aranguren, Hernán, García Rivello, Silvia M M, Magalhaes, Ximena, Valladares, María S, Undurraga, Elvira R P, Velloso

Publikováno v: American journal of hematology. 90(10)

There are previously reported data describing differences between Asian and European patients with Myelodysplastic Syndromes (MDS), few direct comparisons based on cancer registration characteristics or using cohorts to validate scoring systems. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b12d3518a21fc21b3e46b74fc2c64668
https://pubmed.ncbi.nlm.nih.gov/26104573

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A new polymorphism in the human factor VIII gene: implications for linkage analysis in haemophilia A and for the evolution of int22h sequences

Autor: Derrick J. Bowen, Carlos D. De Brasi, Irene B. Larripa, Peter W. Collins

Publikováno v: British Journal of Haematology. 111:544-548

A new polymorphism in the human factor VIII gene has been localized and characterized. It is a biallelic, single nucleotide polymorphism located in intron 22 of the gene, within the 9.5 kb int22h-1 segment. The allelic forms are G (frequency 0.65) an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89267f3eace80168dd679a7dc990333b
https://doi.org/10.1046/j.1365-2141.2000.02373.x

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