Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Irene Anundi"'
Publikováno v:
Acta Pharmacologica et Toxicologica. 51:292-299
Isolated cardiac myocytes from adult rats were used as a model to study the cardiotoxicity of free and DNA-linked daunorubicin. The toxic effects on the myocytes were evaluated by studying morphological changes, trypan blue exclusion and cell membran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::211146a8f792707c643aec58940c59b1
https://doi.org/10.1111/j.1600-0773.1982.tb01029.x
https://doi.org/10.1111/j.1600-0773.1982.tb01029.x
Publikováno v:
Biochemical Pharmacology. 45:1251-1259
To study the mechanism of centrilobular damage developing in the centrilobular region after high doses of acetaminophen (APAP), its metabolism and toxicity were compared in periportal and perivenous hepatocytes isolated by digitonin/collagenase perfu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc778b487ae1356a19befc340a768ba9
https://doi.org/10.1016/0006-2952(93)90277-4
https://doi.org/10.1016/0006-2952(93)90277-4
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 8(4)
The flavonoid silymarin and its main active component silybin have been used in the treatment of toxic liver diseases. In order to evaluate the hepatoprotective potency of both these compounds, their effects on the viability, lipid peroxidation and r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95cd0f77c967970c219de066ecadd47
https://pubmed.ncbi.nlm.nih.gov/20692965
https://pubmed.ncbi.nlm.nih.gov/20692965
Publikováno v:
Toxicology in Vitro. 8:577-579
The effects of the hepatoprotective compound silymarin on hepatocytes in primary culture were studied. Exposure of cells in primary culture (both conventional cells and perivenous or periportal cells isolated by the digitonin-collagenase perfusion te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f77580aabcff772b46321b6b91a31d0
https://doi.org/10.1016/0887-2333(94)90020-5
https://doi.org/10.1016/0887-2333(94)90020-5
Publikováno v:
Chemico-biological interactions. 91(1)
The involvement of the alcohol-inducible cytochrome P450 2E1 in the hepatoprotective mechanism of the plant flavonoid extract silymarin, and its main active component silybin, was investigated in isolated hepatocytes. Allyl alcohol toxicity, associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6173e518714bef6f4723cbcdd05c109a
https://pubmed.ncbi.nlm.nih.gov/8194125
https://pubmed.ncbi.nlm.nih.gov/8194125
Autor:
Irene Anundi, Kai O. Lindros
Publikováno v:
Pharmacologytoxicology. 70(6 Pt 1)
The involvement of cytochrome P450 in the liver toxicity of the potent carcinogen, N-nitrosodimethylamine (NDMA) was investigated in hepatocytes isolated from the periportal or perivenous region by digitonin-collagenase perfusion. Exposure of hepatoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f4d20d7a665c04fb5fa5cbc9ea1e254
https://pubmed.ncbi.nlm.nih.gov/1438024
https://pubmed.ncbi.nlm.nih.gov/1438024
Publikováno v:
Hepatology (Baltimore, Md.). 13(2)
Viability, glycolytic capacity and energy metabolism under anaerobic conditions were studied in the hepatoma cell lines HTC, FU5 and HepG2 and in rat and human hepatocytes using glucose and fructose as glycolytic precursors. During 6 hr of anaerobic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb48e7602f4ff151013980ec6eae2a5
https://pubmed.ncbi.nlm.nih.gov/1847350
https://pubmed.ncbi.nlm.nih.gov/1847350
Publikováno v:
Archives of Toxicology. 55:11-15
The protective effect of N-acetylcysteine against the toxicity of paracetamol, acrolein, and paraquat was investigated using isolated hepatocytes as the experimental system. N-acetylcysteine protects against paracetamol toxicity by acting as a precur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90690236b018b55f27a5652862267b3b
https://doi.org/10.1007/bf00316579
https://doi.org/10.1007/bf00316579
Publikováno v:
Archives of Toxicology. 50:113-123
Cellular lysis in freshly isolated hepatocytes incubated with varying concentrations of selenite could be related to the reductive metabolism of selenite. A decrease in intracellular GSH levels was observed concomitant with an increased rate of accum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1babadd5d23a6406641eb187f26baa11
https://doi.org/10.1007/bf00373393
https://doi.org/10.1007/bf00373393
Publikováno v:
Chemico-Biological Interactions. 50:277-288
Isolated hepatocytes incubated with selenite (30–100 μM) exhibited changes in the glutathione redox system as shown by an increase in O 2 consumption, oxidation of glutathione and loss of NADPH. Selenite (50 μM) raised O 2 consumption within the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce6dd1196098e70fed2dd950b82c8c43
https://doi.org/10.1016/0009-2797(84)90037-1
https://doi.org/10.1016/0009-2797(84)90037-1