Výsledky vyhledávání - "Irene Amigo-Jiménez"

Akademický článek

Matrix metalloproteinase-9 is involved in chronic lymphocytic leukemia cell response to fludarabine and arsenic trioxide.

Autor: Irene Amigo-Jiménez, Elvira Bailón, Estefanía Ugarte-Berzal, Noemí Aguilera-Montilla, José A García-Marco, Angeles García-Pardo

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e99993 (2014)

BackgroundMatrix metalloproteinase-9 (MMP-9) contributes to chronic lymphocytic leukemia (CLL) pathology by regulating cell migration and preventing spontaneous apoptosis. It is not known if MMP-9 is involved in CLL cell response to chemotherapy and

Externí odkaz: https://doaj.org/article/2cebfa6706cf4c8e9f6b47ea8fab24e6

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Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9

Autor: Noemí Aguilera-Montilla, José A. García Marco, Elvira Bailón, Angeles García-Pardo, Irene Amigo-Jiménez

Publikováno v: Oncotarget
Digital.CSIC. Repositorio Institucional del CSIC
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19 p.-9 fig.-1 tab.
CLL remains an incurable disease in spite of the many new compounds being tested. Arsenic trioxide (ATO) induces apoptosis in all CLL cell types and could constitute an efficient therapy. To further explore this, we have stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::700489c64caa04d21df6e582d53f3baa
http://europepmc.org/articles/PMC5347775

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Bone marrow stroma-induced resistance of chronic lymphocytic leukemia cells to arsenic trioxide involves Mcl-1 upregulation and is overcome by inhibiting the PI3Kδ or PKCβ signaling pathways

Autor: Noemí Aguilera-Montilla, Angeles García-Pardo, María José Terol, José A. García-Marco, Irene Amigo-Jiménez, Elvira Bailón

Publikováno v: Oncotarget

CLL remains an incurable disease in spite of the many new compounds being studied. Arsenic trioxide (ATO) induces apoptosis in all CLL cell types and could constitute an efficient therapy. To further explore this, we have studied the influence of str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::382f19502ea7e780e536c2e6f8c08750
http://europepmc.org/articles/PMC4792595

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Arsenic trioxide synergistically potentiates the cytotoxic effect of fludarabine in chronic lymphocytic leukemia cells by further inactivating the Akt and ERK signaling pathways

Autor: Sara Nova-Gurumeta, Angeles García-Pardo, José A. García-Marco, Irene Amigo-Jiménez, Carol Lozano-Santos, Nuria Pérez-Sanz

Publikováno v: Biochemical and biophysical research communications. 461(2)

CLL remains an incurable disease, making it crucial to continue searching for new therapies efficient in all CLL cases. We have studied the effect of combining arsenic trioxide (ATO) with fludarabine, a frontline drug in CLL. We have found a synergis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e927b5d2c9394ac993120114ae5836b
https://pubmed.ncbi.nlm.nih.gov/25869069

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Matrix Metalloproteinase-9 Is Involved in Chronic Lymphocytic Leukemia Cell Response to Fludarabine and Arsenic Trioxide

Autor: Angeles García-Pardo, Estefania Ugarte-Berzal, Irene Amigo-Jiménez, Elvira Bailón, José A. García-Marco, Noemí Aguilera-Montilla

Publikováno v: PLoS ONE
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS ONE, Vol 9, Iss 6, p e99993 (2014)

16 p.-1 tab.-11 fig.
Background: Matrix metalloproteinase-9 (MMP-9) contributes to chronic lymphocytic leukemia (CLL) pathology by regulating cell migration and preventing spontaneous apoptosis. It is not known if MMP-9 is involved in CLL cell r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac9a9d532583e3460787178e7796e4c6
http://europepmc.org/articles/PMC4067296

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A novel CD44-binding peptide from the pro-matrix metalloproteinase-9 hemopexin domain impairs adhesion and migration of chronic lymphocytic leukemia (CLL) cells

Autor: Irene Amigo-Jiménez, Juan Pablo Albar, Angeles García-Pardo, José A. García-Marco, Estefania Ugarte-Berzal, Elvira Bailón

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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11 p.-6 fig.-2 tab.
(pro)MMP-9 binds to CLL cells through the PEX9 domain and contributes to CLL progression. To biochemically characterize this interaction and identify potential therapeutic targets, we prepared GST-PEX9 forms containing struct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02090bb139c1d4c525363b0586a60ceb
http://hdl.handle.net/10261/154615

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Overexpression of progelatinase B/proMMP-9 affects migration regulatory pathways and impairs chronic lymphocytic leukemia cell homing to bone marrow and spleen

Autor: Elvira Bailón, Philippe E. Van den Steen, Irene Amigo-Jiménez, José A. García-Marco, Angeles García-Pardo, Ghislain Opdenakker, Estefania Ugarte-Berzal

Publikováno v: Journal of leukocyte biology.

This study addresses the role of (pro)MMP-9 overexpression in CLL cell migration. We have used primary CLL cells and CLL-derived MEC-1 cells transfected with empty (mock cells) or proMMP-9-encoding (MMP-9 cells) lentiviral vectors. The constitutive (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c984e93c9d326e589bd124630900c02
https://pubmed.ncbi.nlm.nih.gov/24620030

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A 17-residue sequence from the matrix metalloproteinase-9 (MMP-9) hemopexin domain binds α4β1 integrin and inhibits MMP-9-induced functions in chronic lymphocytic leukemia B cells

Autor: María José Terol, Estefania Ugarte-Berzal, Elvira Bailón, Cidônia de Lourdes Vituri, Mercedes Hernández del Cerro, José A. García-Marco, Angeles García-Pardo, Germán Rivas, Irene Amigo-Jiménez, Juan Pablo Albar

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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13 páginas, 7 figuras, 2 tablas -- PAGS nros. 27601-27613
We previously showed that pro-matrix metalloproteinase-9 (proMMP-9) binds to B chronic lymphocytic leukemia (B-CLL) cells and contributes to B-CLL progression by regulating cell migratio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681303342119a10dc98d193cb460d6db
http://hdl.handle.net/10261/60321

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Abstract A03: Novel functions of matrix metalloproteinase-9 contributing to B-cell chronic lymphocytic leukemia progression

Autor: Irene Amigo-Jiménez, Angeles García-Pardo, José A. García-Marco, Estefania Ugarte-Berzal, Elvira Bailón

Publikováno v: Clinical Cancer Research. 21:A03-A03

Chronic lymphocytic leukemia (CLL) cells secrete matrix metalloproteinase-9 (MMP-9) and express it on their surface. We previously showed that surface-bound MMP-9 binds to alpha4beta1 integrin and CD44v and contributes to CLL progression since: 1) el

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d16865cf7c62560e8ff78697ca0f292
https://doi.org/10.1158/1557-3265.hemmal14-a03

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Abstract B18: Blocking α4β1 integrin interaction with matrix metalloproteinase-9 overcomes stroma-induced resistance of chronic lymphocytic leukemia cells to fludarabine and arsenic trioxide

Autor: Angeles García-Pardo, Estefania Ugarte-Berzal, Elvira Bailón, Irene Amigo-Jiménez, José A. García-Marco

Publikováno v: Cancer Research. 75:B18-B18

Chronic lymphocytic leukemia (CLL) progression is determined by CLL cell accumulation in lymphoid organs, where they receive survival signals that impair therapeutic treatments. MMP-9 is a microenvironment component and we have shown that induces a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a540e647d65f78567c2bd1c825294c0
https://doi.org/10.1158/1538-7445.chtme14-b18

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