Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Irene Aksoy"'
Autor:
Constance Onfray, Simon Chevolleau, Eva Moinard, Océane Girard, Kasturi Mahadik, Ryan Allsop, Grigorios Georgolopoulos, Régis Lavigne, Ophélie Renoult, Irene Aksoy, Elsa Lemaitre, Philippe Hulin, Jean-François Ouimette, Thomas Fréour, Claire Pecqueur, Charles Pineau, Vincent Pasque, Claire Rougeulle, Laurent David
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114232- (2024)
Summary: The advent of novel 2D and 3D models for human development, including trophoblast stem cells and blastoids, has expanded opportunities for investigating early developmental events, gradually illuminating the enigmatic realm of human developm
Externí odkaz:
https://doaj.org/article/2001271c8ec84739b50726e1669c44a5
Autor:
Kagistia H Utami, Axel M Hillmer, Irene Aksoy, Elaine G Y Chew, Audrey S M Teo, Zhenshui Zhang, Charlie W H Lee, Pauline J Chen, Chan Chee Seng, Pramila N Ariyaratne, Sigrid L Rouam, Lim Seong Soo, Saira Yousoof, Ivan Prokudin, Gregory Peters, Felicity Collins, Meredith Wilson, Alyson Kakakios, Georges Haddad, Arnaud Menuet, Olivier Perche, Stacey Kiat Hong Tay, Ken W K Sung, Xiaoan Ruan, Yijun Ruan, Edison T Liu, Sylvain Briault, Robyn V Jamieson, Sonia Davila, Valere Cacheux
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e90852 (2014)
Delineating candidate genes at the chromosomal breakpoint regions in the apparently balanced chromosome rearrangements (ABCR) has been shown to be more effective with the emergence of next-generation sequencing (NGS) technologies. We employed a large
Externí odkaz:
https://doaj.org/article/f08ec6b361204c559748e2e486235dd1
Autor:
Georges Lacaud, Pierre Savatier, Renaud Mevel, Syed Murtuza Baker, Irene Aksoy, Wen Hao Neo, Rahima Patel, Valerie Kouskoff, Magnus Rattray, Laura Fontenille, Roshana Thambyrajah, Nam Do Khoa, Muhammad Zaki Hidayatullah Fadlullah, Michael Lie-A-Ling
Publikováno v:
Fadlullah, M Z H, Neo, W H, Lie-a-ling, M, Thambyrajah, R, Patel, R, Mevel, R, Aksoy, I, Do Khoa, N, Savatier, P, Fontenille, L, Baker, S M, Rattray, M, Kouskoff, V & Lacaud, G 2022, ' Murine AGM single-cell profiling identifies a continuum of hemogenic endothelium differentiation marked by ACE ', Blood, vol. 139, no. 3, pp. 343-356 . https://doi.org/10.1182/blood.2020007885, https://doi.org/10.1182/blood.2020007885
In vitro generation and expansion of hematopoietic stem cells (HSCs) holds great promise for the treatment of any ailment that relies on bone marrow or blood transplantation. To achieve this, it is essential to resolve the molecular and cellular path
Autor:
Pierre Savatier, Irene Aksoy
Publikováno v:
médecine/sciences. 37:863-872
Les chimères inter-espèces sont à la fois les créatures fantastiques et monstrueuses des mythologies grecque ou égyptienne, et un outil de recherche établi de longue date. Des avancées récentes dans le domaine des cellules souches pluripotent
Autor:
Chit Fang Cheok, Irene Aksoy, Julieta Aprea, Lawrence W. Stanton, Sara Bragado Alonso, Philipp Kaldis, Federico Calegari, Shuhui Lim, Akshay Bhinge
Sox2 is known to be important for neuron formation, but the precise mechanism through which it activates a neurogenic program and how this differs from its well-established function in self-renewal of stem cells remain elusive. In this study, we iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c1187e59dffd09cd00db69c2213d383
http://hdl.handle.net/10220/43570
http://hdl.handle.net/10220/43570
Autor:
Lawrence W. Stanton, Volker Eras, Ushashree Divakar, Prasanna R. Kolatkar, Ralf Jauch, Calista Keow Leng Ng, Irene Aksoy, Wen Bin Alfred Chng, Jiaxuan Chen
Publikováno v:
Stem Cells. 31:2632-2646
The unique ability of Sox2 to cooperate with Oct4 at selective binding sites in the genome is critical for reprogramming somatic cells into induced pluripotent stem cells (iPSCs). We have recently demonstrated that Sox17 can be converted into a repro
Autor:
Irene Aksoy, Lawrence W. Stanton
Publikováno v:
Current Molecular Medicine. 13:695-706
The reprogramming of somatic cells into induced pluripotent stem cells or iPS cells can be achieved by the ectopic expression of defined factors. Patient-specific iPS cell lines can be derived and used for disease modeling, drug and toxicology screen
A Role for RE-1-Silencing Transcription Factor in Embryonic Stem Cells Cardiac Lineage Specification
Autor:
Mehran Rahmani, Vibhor Kumar, Noel J. Buckley, Ushashree Divakar, Guillaume Marcy, Jiaxuan Chen, Irene Aksoy, Lawrence W. Stanton, Daniel John‐Sanchez
Publikováno v:
Stem cells (Dayton, Ohio). 34(4)
During development, lineage specification is controlled by several signaling pathways involving various transcription factors (TFs). Here, we studied the RE-1-silencing transcription factor (REST) and identified an important role of this TF in cardia
Autor:
Pierre-Yves Bourillot, Florence Wianny, Norbert Hubner, Irene Aksoy, Herbert Schulz, Pierre Savatier, Valerie Schreiber, Oliver Hummel
Publikováno v:
Stem Cells. 27:1760-1771
Leukemia inhibitory factor (LIF) activates the transcription factor signal transducer and activator of transcription 3 (STAT3), which results in the maintenance of mouse embryonic stem cells in the pluripotent state by inhibiting both mesodermal and
Autor:
Stacey K.H. Tay, Hoang Truong Long, Kagistia Hana Utami, Herty Liany, Sinnakaruppan Mathavan, Elaine G.Y. Chew, Axel M. Hillmer, Cecilia Lanny Winata, Irene Aksoy, Pierre Sarda, Vladimir Korzh, Sonia Davila, Valère Cacheux
Publikováno v:
Human Mutation.
MED13L is a component subunit of the Mediator complex, an important regulator of transcription that is highly conserved across eukaryotes. Here, we report MED13L disruption in a translocation t(12;19) breakpoint of a patient with Pierre-Robin syndrom