Diacylglycerol kinase α inhibition cooperates with PD-1-targeted therapies to restore the T cell activation program

Autor: Javier Arranz-Nicolás, Antonia Ávila-Flores, Rosa Liébana, Judith Leitner, Peter Steinberger, María del Carmen Moreno-Ortiz, Isabel Mérida, Miguel Martin-Salgado, Irene Adán-Barrientos

Publikováno v: Cancer immunology, immunotherapy : CII. 70(11)

Antibody-based therapies blocking the programmed cell death-1/ligand-1 (PD-1/PD-L1) axis have provided unprecedent clinical success in cancer treatment. Acquired resistance, however, frequently occurs, commonly associated with the upregulation of add

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::949fbe7da887daf15c38872b919af67e
https://pubmed.ncbi.nlm.nih.gov/33837851

Dendritic Cell‐Mediated Cross‐Priming by a Bispecific Neutralizing Antibody Boosts Cytotoxic T Cell Responses and Protects Mice against SARS‐CoV‐2.

Autor: Lázaro‐Gorines, Rodrigo^1,2,3 (AUTHOR), Pérez, Patricia^4,5 (AUTHOR), Heras‐Murillo, Ignacio⁶ (AUTHOR), Adán‐Barrientos, Irene⁶ (AUTHOR), Albericio, Guillermo⁴ (AUTHOR), Astorgano, David⁴ (AUTHOR), Flores, Sara⁴ (AUTHOR), Luczkowiak, Joanna⁷ (AUTHOR), Labiod, Nuria⁷ (AUTHOR), Harwood, Seandean L.⁸ (AUTHOR), Segura‐Tudela, Alejandro^1,2,3 (AUTHOR), Rubio‐Pérez, Laura^1,2,3,9 (AUTHOR), Nugraha, Yudhi¹⁰ (AUTHOR), Shang, Xiaoran^11,12 (AUTHOR), Li, Yuxing^11,12,13 (AUTHOR), Alfonso, Carlos¹⁴ (AUTHOR), Adipietro, Kaylin A.^13,15 (AUTHOR), Abeyawardhane, Dinendra L.^11,13,15 (AUTHOR), Navarro, Rocío¹⁶ (AUTHOR), Compte, Marta¹⁶ (AUTHOR)

Publikováno v: Advanced Science. Dec2023, Vol. 10 Issue 34, p1-17. 17p.